(-)-Di-p-toluoyl-L-tartaric acid

Uses

Product Name: (-)-Di-p-toluoyl-L-tartaric acid
CAS No.: 32634-66-5
Chemical Name: (-)-Di-p-toluoyl-L-tartaric acid
Synonyms: DTTA;LDTTA;DI-P-TOLUOYL-L-TARTARIC ACID;L-PTTA;(-)-DI-P-TOLUOYL-L-TRATARIC ACID;L-(-)-TARTARIC ACID DI-4-TOLUOYL ESTER;DI-P-TOLUOYL-L-TARTARIC ACID MONOHYDRATE;DPTTA Salt;(-)-Di-p-toluoyl-L-t;Tofacitib impurity 32
CBNumber: CB8229472
Molecular Formula: C20H18O8
Formula Weight: 386.35
MOL File: 32634-66-5.mol

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(-)-Di-p-toluoyl-L-tartaric acid Property

Melting point:: 169-171 °C(lit.)
alpha: -142 º (c=10, EtOH)
Boiling point:: 432.57°C (rough estimate)
Density: 1.3084 (rough estimate)
bulk density: 500kg/m3
refractive index: -139 ° (C=1, EtOH)
storage temp.: Store below +30°C.
solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka: 1.46±0.25(Predicted)
form: Crystalline Powder
color: White to yellow
optical activity: [α]20/D 138°, c = 1 in ethanol
Water Solubility: soluble
BRN: 2022481
CAS DataBase Reference: 32634-66-5(CAS DataBase Reference)
EPA Substance Registry System: Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, [R-(R*,R*)]- (32634-66-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36/37-26
WGK Germany: 3
TSCA: T
HS Code: 29181300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.18725
Product name: (2R,3R)-(-)-Di-O-4-toluoyl-L-tartaric acid
Purity: forsynthesis
Packaging: 25g
Price: $114
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.18725
Product name: (2R,3R)-(-)-Di-O-4-toluoyl-L-tartaric acid
Purity: forsynthesis
Packaging: 100g
Price: $251
Updated: 2025/07/31

Sigma-Aldrich

Product number: 371416
Product name: (?)-O,O′-Di-p-toluoyl-L-tartaric acid
Purity: 97%
Packaging: 25g
Price: $112
Updated: 2025/07/31

TCI Chemical

Product number: D1387
Product name: (-)-Di-p-toluoyl-L-tartaric Acid
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $17
Updated: 2025/07/31

TCI Chemical

Product number: D1387
Product name: (-)-Di-p-toluoyl-L-tartaric Acid
Purity: >98.0%(HPLC)(T)
Packaging: 250g
Price: $72
Updated: 2025/07/31

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(-)-Di-p-toluoyl-L-tartaric acid Chemical Properties,Usage,Production

Uses

(-)-di-p-toluoyl-l-tartaric acid can be used as a chiral resolving agent for the resolution of the racemic bases to isolate the (-)-enantiomeric forms.

Chemical Properties

white to light yellow crystal powde

Uses

Escitalopram intermediate

Uses

(-)-O,O’-Di-p-toluoyl-L-tartaric Acid is a useful reagent for the preparation of the upadacitinib salt compound.

Uses

Inhibitor of enzyme

General Description

(-)-O,O′-Di-p-toluoyl-L-tartaric acid is a O,O′-diacyl tartaric acid derivative that can be prepared by the resolution of its racemate in the presence of cinchonine.

Synthesis

869749-09-7

32634-66-5

243640-19-9

The general procedure for the synthesis of di-p-toluoyltartaric acid and compound (CAS: 243640-19-9) from compound (CAS: 869749-09-7) was as follows: (R)-α-(2,3-dimethoxyphenyl)-4-piperidine methanol was mixed with (2R,3R)-(-)-di-(p-toluoyl)tartaric acid salt (7 g) in 10 mL of concentrated ammonia and methanol were stirred well. After 2 hours of reaction, 30 mL of water was added and evaporated to remove methanol and ammonia. Subsequently, another 30 mL of water was added and the precipitate was collected, rinsed with water and dried to give (R)-α-(2,3-dimethoxyphenyl)-4-piperidine methanol (1), which typically has an enantiomeric excess of 85% (ee). After acidification of the aqueous layer with 1N hydrochloric acid, the precipitate was collected and dried to recover (2R,3R)-(-)-di-(p-toluoyl)tartaric acid.

References

[1] Patent: EP1734037, 2006, A2. Location in patent: Page/Page column 53

(-)-Di-p-toluoyl-L-tartaric acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-Di-p-toluoyl-L-tartaric acid Suppliers

Americas 1 Belgium 2 Canada 3 China 385 Europe 5 France 5 Germany 7 Hungary 2 India 50 Italy 1 Japan 4 Poland 2 Slovakia 1 South Korea 2 Switzerland 3 United Kingdom 23 United States 51 Global 547

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View Lastest Price from (-)-Di-p-toluoyl-L-tartaric acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: (-)-Di-p-toluoyl-L-tartaric acid 32634-66-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 10000kg
Release date: 2025-08-02

Shaanxi Dideu New Materials Co. Ltd

Product: (-)-Di-p-toluoyl-L-tartaric acid 32634-66-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-05-15

Henan Aochuang Chemical Co.,Ltd.

Product: (-)-Di-p-toluoyl-L-tartaric acid 32634-66-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

32634-66-5, (-)-Di-p-toluoyl-L-tartaric acidRelated Search:

Hexamethylphosphoramide D(-)-Tartaric acid Benzoyl peroxide (+)-Dibenzoyl-D-tartaric acid L(+)-Tartaric acid O-Phthalimide Calcium folinate Dimethyl sulfone Folic acid Ethyl 2-(Chlorosulfonyl)acetate Dibenzoyl-L-tartaric acid DL-Tartaric acid Glycine Tosyl cyanide L(+)-Diethyl L-tartrate 4-Chloro-3-Pyridine-sulfonyl-chloride 4-Hydroxypyridine-3-sulfonic acid 4-(Hydroxyamino)-4-oxobutanoic acid

(-)-Ditoluoyl-(L)-tartaric acid monohydrate

Di-4-Toluoyl-L-tartaric acid

(-)-2,3-DI-P-TOLUOYL-L-TARTARIC ACID

Di-p-Toluyl-L-Tartaric Acid Anhydrous

(-)-DI-O,O'-P-TOLUOYL-L-TARTARIC ACID

Di-Para-Toluoyl-D-TartaricAcid,Anhydrous

Di-Para-Toluoyl-L-TartaricAcid

Di-P-Toluoyl-L-TartaricAcid(Anhydrous)

Di-p-Toluoy-L-Tartaric Acid

O,ODi-p-toluoyl-Lg-tartaric Acid

O,ODi-p-toluoyl-Dg-tartaric Acid

o,o-ToluoyllTartaricAcid

L-(-)-Dio,o'-p-Toluyl-L-tartar

DL-P-Toluoyl-L-Tartaric Acid

Butanedioic acid, 2,3-bis(4-methylbenzoyl)oxy-, R-(R*,R*)-

(2R,3R)-2,3-Bis[(4-methylbenzoyl)oxy]succinic acid

(-)-DI-O,O''-P-TOLUYL-L-WEINSURE

2,3-bis[(4-methylbenzoyl)oxy]-,[theta-(theta,theta)]-butanedioicaci

2,3-bis[(4-methylbenzoyl)oxy]-, [ theta-( theta, theta)]-butanedioic acid

DI-(4-METHYLBENZOYL)-L-TARARIC ACID

DI-P-TOTUOYL-L-TARTARIC ACID

L-(-)-DI-P-TOLUOYL-L-TARTARIC ACID anhydrous

(-)-Di-p-toluoyl-L-tartaric acid (-)-Di-1,4-O-toluoyl-L-tartaric acid

(-)-Di-<i>p-</i>toluoyl-L-tartaric acid

(-)-O,O'-Di-p-toluoyl-L-tartaric acid 97%

(-)-Di-O-Ol-P-Toluyl-L-Tartaric acid

Butanedioicacid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2R,3R)-

(-)-Di-p-toluoyl-L-tartaric acid (Anhydrous)≥ 99% (HPLC)

(2R,3R)-(-)-Di-O-4-toluoyl-L-tartaric acid for synthesis

(-)-O,O'-Di-1,4-toluoyl-L-tartaric acid

L-(-)-Di-1,4-O-tolyltartaric acid

(2R,3R)-(-)-DI-O-4-TOLUOYL-L-TARTARIC ACID, 99+%

(-)-O,O'-Di-p-toluoyl-L-tartaric acid, (2R,3R)-(-)-2,3-Bis[(4-methylbenzoyl)oxy]succinic acid

(2R,3R)-(-)-2,3-Bis[(4-methylbenzoyl)oxy]butane-1,4-dioic acid

(-)-Di-p-toluoyl-L-tartaric acid, ee: 99%

O,O'-DI-POLUOYL-D-TARTARIC ACID ANHYDROUS

Paroxetine Impurity 60

LDTTA

L-(-)-DI-P-TOLUOYLTARTARIC ACID

L-(-DI-P-TOLUOYL TARTARIC ACID)

L-(-)-TARTARIC ACID DI-4-TOLUOYL ESTER

L-(-)-TARTARIC ACID-O,O'-DI-P-TOLUOYL ESTER

L-PTTA

(-)-DI-1,4-O-TOLUOYL-L-TARTARIC ACID

(-)-DI-1,4-TOLUOYL-L-TARTARIC ACID

D-(+)-DI-P-TOLUOYL-D-TARTARIC ACID

DTTA

(-)-DI-O,O'-P-TOLUYL-L-TARTARIC ACID

DI-O-4-TOLUOYL-L-TARTARIC ACID

(-)-DI-P-TOLUOYL-L-TRATARIC ACID

(-)-DI-P-TOLUOYL-L-TARTARIC ACID

DI-P-TOLUOYL-L-TARTARIC ACID

DI-P-TOLUOYL-L-TARTARIC ACID MONOHYDRATE

(2R,3R)-(-)-DI-O-4-TOLUOYLTARTARIC ACID

(2R,3R)-(-)-DI-O-4-TOLUOYL-L-TARTARIC ACID

(-)-Di-p-toluoyl-(L)-tartaric acid monohydrate anhydrous

(?-O,O-Di-p-toluyl-L-tartaric acid

[R(R*,R*)]-2,3-bis[(4-methylbenzoyl)oxy]succinic acid