Malotilate

Product Name: Malotilate
CAS No.: 59937-28-9
Chemical Name: Malotilate
Synonyms: DDYM;Kantec;nkk105;cl-1500;Hepation;MaIotilate;MALOTILATE;MALOTILATUM;MALOTILATE 98%;Malotilate, BR
CBNumber: CB8227928
Molecular Formula: C12H16O4S2
Formula Weight: 288.38
MOL File: 59937-28-9.mol

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Malotilate Property

Melting point:: 60.5°
Boiling point:: 400.61°C (rough estimate)
Density: 1.3727 (rough estimate)
refractive index: 1.4950 (estimate)
storage temp.: 2-8°C
solubility: soluble in Methanol,Ether,Benzene
form: powder to crystal
color: White to Light yellow
Merck: 14,5712
CAS DataBase Reference: 59937-28-9(CAS DataBase Reference)

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Safety

RTECS: OO0970000
HS Code: 2934.99.4700

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2674
Product name: Malotilate
Purity: >98.0%(GC)
Packaging: 1g
Price: $121
Updated: 2024/03/01

TCI Chemical

Product number: M2674
Product name: Malotilate
Purity: >98.0%(GC)
Packaging: 5g
Price: $363
Updated: 2024/03/01

Cayman Chemical

Product number: 30266
Product name: Malotilate
Packaging: 1g
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 30266
Product name: Malotilate
Packaging: 5g
Price: $270
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0003245
Product name: MALOTILATE
Purity: 95.00%
Packaging: 5G
Price: $327.6
Updated: 2021/12/16

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Malotilate Chemical Properties,Usage,Production

Description

Malotilate is a hepatoprotective agent reported to be effective in the treatment of cirrhosis, chronic hepatitis and similar liver disorders. It appears to improve hepatic function by increasing blood and bile flow and improving protein synthesis.

Description

Malotilate is a hepatoprotective agent. It inhibits A23187-induced metabolism of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) to the 5-lipoxygenase (5-LO) metabolites leukotriene B₄ (LTB₄; ) and 5-HETE in macrophages isolated from the ascitic fluid of patients with alcoholic liver cirrhosis. Malotilate (50 mg/kg) prevents increases in plasma glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) activities in a rat model of carbon tetrachloride-induced liver injury. It reduces hepatic deposition of type III procollagen, type IV collagen, laminin, and fibronectin in a rat model of dimethylnitrosamine-induced hepatic fibrosis when administered at a dose of 100 mg/kg.

Originator

Nihon Nohyaku (Japan)

Definition

ChEBI: Malotilate is an isopropyl ester.

brand name

KANTEC

in vitro

the in-vitro invasion assay employing a rat lung endothelial cell monolayer indicated that pretreatment of the lung endothelial cells, but not c-sst-2 cells, with malotilate reduced the invasion of the rle monolayer by c-sst-2 cells significantly. the in-vitro vascular permeability assay also demonstrated malotilate could prevent the permeability increase of the lung endothelial cell monolayer by serum starvation. in contrast, the gelatinase production and adhesion to the rle cell monolayer of c-sst-2 cells were not affected by malotilate treatment [1].

in vivo

malotilate was administered to syngeneic shr rats orally from 7 days before or after s.c. inoculation of c-sst-2 cells until the end of the experiments. in the malotilate-treated rats, pulmonary metastasis was suppressed markedly when compared with the non-treated rats. moreover, in the rats treated with malotilate for 19 days after inoculation of c-sst-2 cells, lung metastasis was also suppressed significantly [1].

References

[1] nagayasu h,hamada j,kawano t,konaka s,nakata d,shibata t,arisue m,hosokawa m,takeichi n,moriuchi t. inhibitory effects of malotilate on invasion and metastasis of rat mammary carcinoma cells by modifying the functions of vascular endothelial cells. br j cancer.1998 may;77(9):1371-7.
[2] takase s,matsuda y,yasuhara m,takada a. effects of malotilate treatment on alcoholic liver disease. alcohol.1989 may-jun;6(3):219-22.

Malotilate Preparation Products And Raw materials

Raw materials

Diisopropyl malonate Nitromethane Dicarboxylic Acid 1,1,1-Trichloroethane 5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide Iodomethane Praseodymium(III) nitrate hexahydrate 1,3-Cyclopentadiene

Preparation Products

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Malotilate Suppliers

Americas 1 Belgium 1 CHINA 120 Europe 5 Germany 3 India 2 Japan 1 United Kingdom 5 United States 23 Global 161

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View Lastest Price from Malotilate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Malotilate 59937-28-9
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 98%min
Supply Ability: 100kg
Release date: 2021-11-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: Malotilate 59937-28-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Malotilate 59937-28-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

59937-28-9, MalotilateRelated Search:

Isopropyl acetate BUTYL OLEATE Diisopropyl malonate Isopropyl myristate Dimethyl malonate Tris(trimethylsilyl)phosphate Diethyl malonate Malonic acid Methyl acrylate TOLUENE-3,4-DITHIOL Diisopropyl phosphite Isopropyl palmitate 2,2-Dimethyl-1,3-dioxane-4,6-dione Diethyl methylmalonate Cyclopentene DIMETHYL 2-[DI(METHYLTHIO)METHYLIDENE]MALONATE Malotilate 2-(BIS-METHYLSULFANYL-METHYLENE)-MALONIC ACID DIETHYL ESTER

1,3-Dithiol-2-ylidenepropanedioic acid bis(1-methylethyl) ester

Dipropan-2-yl 2-(1,3-dithiol-2-ylidene)propanedioate

Hepation

Kantec

MaIotilate

1,3-Dithiol-2-ylidenemalonic acid diisopropyl ester

2-(1,3-Dithiol-2-ylidene)propanedioic acid diisopropyl ester

2-[1,3-Dithiol-2-ylidene]propanedioic acid di(isopropyl) ester

DDYM

Propanedioic acid, 2-(1,3-dithiol-2-ylidene)-, 1,3-bis(1-Methylethyl) ester

diisopropyl 2-(1,3-dithiol-2-ylidene)malonate

MALOTILATE 98%

Malotilate, >=98%

(1,3-dithiol-2-ylidene)-malonicacidiisopropylester

cl-1500

diisopropyl-1,3-dithiol-2-ylidenemalonate

diisopropyl1,3-dithiol-2-ylidenemalonate

nkk105

MALOTILATE

MALOTILATUM

Malotilate, BR

Malotilate Malotilate

Malotilate &gt

Malotilate USP/EP/BP

Malotilate, ≥ 98.0%

59937-28-9

C12H16O4S2

Inhibitors