ChemicalBook > CAS DataBase List > P-XYLENOLPHTHALEIN

P-XYLENOLPHTHALEIN

Product Name: P-XYLENOLPHTHALEIN
CAS No.: 50984-88-8
Chemical Name: P-XYLENOLPHTHALEIN
Synonyms: Xylenolphthalein;P-XYLENOLPHTHALEIN;P-xylenolphthaleine;p-diphenolphthalein;p-Xylenolphthalein;p-xylenolphthalein (pH 9.0-10.5);3,3-bis(4-hydroxy-2,5-xylyl)phthalide;2',5',2'',5''-TETRAMETHYLPHENOLPHTHALEIN;3,3-bis(4-hydroxy-2,5-dimethylphenyl)-2-benzofuran-1-one;P-xylenolphthalein, 2′,5′,2″,5″-tetramethylphenolphthalein
CBNumber: CB8233468
Molecular Formula: C24H22O4
Formula Weight: 374.43
MOL File: 50984-88-8.mol

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P-XYLENOLPHTHALEIN Property

Melting point:: 276°C
Boiling point:: 569.6±50.0 °C(Predicted)
Density: 1.270±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Solubility Insoluble in water; soluble in ethanol, acetone
pka: 9.7(at 25℃)
form: powder
color: Pale yellow or cream-colored
PH Range: Colorless (9.0) to indigo-blue (10.5)
BRN: 346799
Major Application: Inks, detergent, photoresist, toothpaste and mouthwash, disinfectant, cosmetics, paints
InChI: InChI=1S/C24H22O4/c1-13-11-21(25)15(3)9-19(13)24(20-10-16(4)22(26)12-14(20)2)18-8-6-5-7-17(18)23(27)28-24/h5-12,25-26H,1-4H3
InChIKey: PXCIPOXPHMTCIL-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=CC=C2)C(C2=CC(C)=C(O)C=C2C)(C2=CC(C)=C(O)C=C2C)O1

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Safety

WGK Germany: 3
HS Code: 2932.99.7000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 95620
Product name: p-Xylenolphthalein
Purity: for microscopy
Packaging: 5g
Price: $468
Updated: 2022/05/15

TCI Chemical

Product number: X0017
Product name: p-Xylenolphthalein
Packaging: 1g
Price: $31
Updated: 2025/07/31

Matrix Scientific

Product number: 094350
Product name: 3,3-Bis(4-hydroxy-2,5-dimethylphenyl)-isobenzofuran-1(3H)-one
Purity: 95+%
Packaging: 1g
Price: $189
Updated: 2021/12/16

AK Scientific

Product number: 7058AB
Product name: 3,3-Bis(4-hydroxy-2,5-dimethylphenyl)isobenzofuran-1(3H)-one
Packaging: 25g
Price: $438
Updated: 2021/12/16

Matrix Scientific

Product number: 094350
Product name: 3,3-Bis(4-hydroxy-2,5-dimethylphenyl)-isobenzofuran-1(3H)-one
Purity: 95+%
Packaging: 5g
Price: $504
Updated: 2021/12/16

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P-XYLENOLPHTHALEIN Chemical Properties,Usage,Production

Uses

p-Xylenolphthalein is related to phenolphthalein which is used as a pH change indicator.

Synthesis

95-87-4

85-44-9

50984-88-8

General procedure for the synthesis of 3,3-bis-(4-hydroxy-3,6-dimethylphenyl)-1-(3H)-isobenzofuranone from 2,5-dimethylphenol and phthalic anhydride: a mixture of 2,5-dimethylphenol (0.133 mol), phthalic anhydride (0.074 mol), reaction medium (0.416 mol) and Lewis acid (0.029 mol ) were placed in a reaction flask, stirred and heated at 90 °C for 5 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and subsequently slowly poured into an ice-water mixture to induce precipitation of the product. The precipitate was collected by filtration and washed with plenty of water to remove impurities. The crude product was dried and recrystallized from methanol to afford pure 3,3-bis-(4-hydroxy-3,6-dimethylphenyl)-1-(3H)-isobenzofuranone as light yellow crystals in 85% yield. The product was analyzed by IR (KBr) showing that the characteristic absorption peaks were located at 3393 cm^-1 (O-H stretching vibration), 1729 cm^-1 (C=O stretching vibration), and 1611 cm^-1 (C=C stretching vibration of the aromatic ring).The 1H-NMR (DMSO-d6) spectrum showed the following: δ 9.40 (s, 2H, 2×OH), 1.95 (s, 12H, 4 × CH3), 6.59-6.63 (m, 4H, aromatic protons), 7.46-7.91 (m, 4H, aromatic protons) ppm. mass spectrometry analysis showed the molecular ion peak m/z 374 (M+).

References

[1] Patent: US2006/222601, 2006, A1. Location in patent: Page/Page column 25
[2] Tetrahedron Letters, 2009, vol. 50, # 46, p. 6261 - 6263
[3] Zeitschrift fuer Anorganische und Allgemeine Chemie, 1929, vol. 178, p. 54,56
[4] Roczniki Chemii, 1931, vol. 11, p. 103,109; dtsch. Ref. S. 111
[5] Chem. Zentralbl., 1931, vol. 102, # I, p. 2473

P-XYLENOLPHTHALEIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from P-XYLENOLPHTHALEIN manufacturers

Career Henan Chemical Co

Product: P-XYLENOLPHTHALEIN 50984-88-8
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

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P-XYLENOLPHTHALEIN

2',5',2'',5''-TETRAMETHYLPHENOLPHTHALEIN

3,3-Bis(2,5-dimethyl-4-hydroxyphenyl)isobenzofuran-1(3H)-one

3,3-Bis(4-hydroxy-2,5-dimethylphenyl)-1(3H)-isobenzofuranone

3,3-Bis(4-hydroxy-2,5-dimethylphenyl)isobenzofuran-1(3H)-one

4,4'-[(3-Oxo-1,3-dihydroisobenzofuran)-1,1-diyl]bis(2,5-dimethylphenol)

p-xylenolphthalein (pH 9.0-10.5)

P-xylenolphthaleine

3,3-bis(4-hydroxy-2,5-xylyl)phthalide

P-xylenolphthalein, 2′,5′,2″,5″-tetramethylphenolphthalein

Xylenolphthalein

3,3-bis(4-hydroxy-2,5-dimethylphenyl)-2-benzofuran-1-one

1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxy-2,5-dimethylphenyl)-

p-diphenolphthalein

<i>p</i>-Xylenolphthalein

50984-88-8

C24H22O4

Phthalein