MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2

Product Name: MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2
CAS No.: 158584-09-9
Chemical Name: MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2
Synonyms: NFF-3;NFF-2;MMP SUBSTRATE-2;MMP-3 Substrate (NFF-3);MCA-RPKPVE-NVAL-WRK(DNP)-NH2;MCA-RPKPYA-NVA-WM-K(DNP)-NH2;MCA-RPKPVE-NVA-WR-K(DNP)-NH2;Mca-RPKPVE-Nva-WR-Lys(Dnp)-NH2;FLUORESCENT PEPTIDE SUBSTRATE II;MMP-3/MMP-9 FRET substrate、NFF-3
CBNumber: CB8235134
Molecular Formula: C78H110N22O20
Formula Weight: 1675.84
MOL File: 158584-09-9.mol

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MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2 Property

Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMF: 25 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: slightly soluble
form: A crystalline solid
pka: 4.44±0.10(Predicted)
color: yellow
Sequence: {Mca}-Arg-Pro-Lys-Pro-Val-Glu-{Nva}-Trp-Arg-Lys(DNP)-NH2

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 480450
Product name: NFF-2
Purity: A quenched fluorescence substrate for MMPs.
Packaging: 1 mg
Price: $264
Updated: 2025/07/31

Cayman Chemical

Product number: 22188
Product name: NFF-3
Purity: ≥95%
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 22188
Product name: NFF-3
Purity: ≥95%
Packaging: 5mg
Price: $388
Updated: 2024/03/01

AK Scientific

Product number: 2595CW
Product name: (4S)-4-[[(2S)-2-[[(2S)-1-[(2S)-6-Amino-2-[[(2S)-1-[(2S)-5-carbamimidamido-2-[[2-(7-methoxy-2-oxochromen-4-yl)acetyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-6-(2,4-dinitroanilino)-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]amino]-5-oxopentanoicacid
Packaging: 1mg
Price: $201
Updated: 2021/12/16

Chem-Impex

Product number: 32878
Product name: Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2trifluoroacetatesalt
Packaging: 1MG
Price: $260.92
Updated: 2021/12/16

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MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2 Chemical Properties,Usage,Production

Uses

NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity[1].

Biological Activity

Cell permeable: no', 'Primary Target
Matrix Metalloproteinases (MMPs)', 'Product does not compete with ATP.', 'Reversible: no', 'kcat/Km = 5.9 x 104 M-1sec-1 as substrates for MMP-3 (stromelysin-1)

IC 50

MMP-3; MMP-10

References

[1] Giricz O, et al. Comparison of metalloproteinase protein and activity profiling. Anal Biochem. 2011 Feb 1;409(1):37-45. DOI:10.1016/j.ab.2010.09.040

MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2 Suppliers

China 64 Japan 1 Switzerland 2 United Kingdom 1 United States 12 Global 80

GL Biochem (Shanghai) Ltd

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158584-09-9, MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2Related Search:

5-FAM-Amyloid β-Protein (1-40) MCA-PRO-LEU-OH FITC-LC-TAT (47-57) DABCYL-GAMMA-ABU-SER-GLN-ASN-TYR-PRO-ILE-VAL-GLN-EDANS DABCYL-LYS-HCOV-SARS REPLICASE POLYPROTEIN 1AB (3235-3246)-GLU-EDANS MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2 MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2 CHEMBRDG-BB 7932577 3-(2-HYDROXYPHENYL)PROPIONAMIDE L-PYROGLUTAMYL-L-ARGINYL-L-THREONYL-L-LYSYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE MCA-SER-GLU-VAL-ASN-LEU-ASP-ALA-GLU-PHE-ARG-LYS(DNP)-ARG-ARG-NH2 Ac-Val-Arg-Pro-Arg-AMC DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS BENZYLOXYCARBONYL-L-VALYL-L-LYSYL-L-METHIONINE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE PGLU-GLY-ARG P-NITROANILIDE HYDROCHLORID MCA-GLY-LYS-PRO-ILE-LEU-PHE-PHE-ARG-LEU-LYS(DNP)-D-ARG-NH2 AC-IEPD-AMC SUC-ALA-ALA-ALA-AMC

MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS: DNP-NH2 [MCA-RPKPYA-NVA-WM-K: DNP-NH2]

MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-LYS: DNP-NH2 [MCA-RPKPVE-NVA-WRK: DNP-NH2]

7-methoxycoumarin-4-acetyl-arg-pro-*lys-pro-val-G

7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-*LYS- PRO-VAL-GLU

Mca-RPKPVE-Nva-WR-Lys(Dnp)-NH2

7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-(2,4-DINITROPHENYL)-LYS AMIDE

7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-(2,4-DINITROPHENYL)-LYS AMIDE

(7-METHOXYCOUMARIN-4-YL)ACETYL-L-ARGINYL-L-PROLYL-L-LYSYL-L-PROLYL-L-TYROSYL-L-ALANYL-L-NORVALYL-L-TRYPTOPHYL-L-METHIONYL-N-EPSILON-(2,4-DINITROPHENYL)-L-LYSINE AMIDE

(7-METHOXYCOUMARIN-4-YL)ACETYL-L-ARGINYL-L-PROLYL-L-LYSYL-L-PROLYL-L-VALYL-L-GLUTAMYL-L-NORVALYL-L-TRYPTOPHYL-L-ARGINYL-N-EPSILON-(2,4-DINITROPHENYL)-L-LYSINE AMIDE

MCA-RPKPYA-NVA-WM-K(DNP)-NH2

MCA-RPKPVE-NVAL-WRK(DNP)-NH2

MCA-RPKPVE-NVA-WR-K(DNP)-NH2

MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2

MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVAL-TRP-ARG-LYS(DNP)-NH2

MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVAL-TRP-ARG-LYS(NDP)-NH2

MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-LYS(DNP)-NH2

FLUORESCENT PEPTIDE SUBSTRATE II

NFF-3

NFF-2

MOCAC-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2

MOCAC-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-LYS(DNP)-NH2

MMP SUBSTRATE-2

L-Lysinamide, N2-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-valyl-L-α-glutamyl-L-norvalyl-L-tryptophyl-L-arginyl-N6-(2,4-dinitrophenyl)-

MMP-3 Substrate (NFF-3)

390 MMP Substrate XIII, NFF-3 - 1 mg

Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 trifluoroacetate salt

MMP-3/MMP-9 FRET substrate、NFF-3

158584-09-9

C78H110N22O20

Activity

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Extracellular Matrix

Fluorogenic

Metalloproteinase Substrates

Cytoskeleton and Extracellular Matrix

peptide

Activity

Enzyme Substrates

Fluorogenic