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Pramipexole Impurity 16

Product Name
Pramipexole Impurity 16
CAS No.
104632-27-1
Chemical Name
Pramipexole Impurity 16
Synonyms
RPPX;Kns 760704;Snd 919cl2x;Dexpramipexole HCl;Dexpramipexole 2HCl;Pramipexole R-Isomer;PraMipexole IMpurity D;Pramipexole BP Impurity D;Pramipexole impurity D CRS;KNS-760704 dihydrochloride
CBNumber
CB82449027
Molecular Formula
C10H18ClN3S
Formula Weight
247.79
MOL File
104632-27-1.mol
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Pramipexole Impurity 16 Property

storage temp. 
-20°C
solubility 
H2O: >15mg/mL
form 
powder
color 
white to beige
optical activity
[α]/D 60 to 70°, c = 1 in methanol
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
2934200000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1553815
Product name
Pramipexole Related Compound D
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1210
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1824
Product name
Pramipexole Related Compound D
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
50mg
Price
$675
Updated
2022/05/15
Cayman Chemical
Product number
18234
Product name
(R)-Pramipexole (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$65
Updated
2024/03/01
Cayman Chemical
Product number
18234
Product name
(R)-Pramipexole (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$121
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0392
Product name
Dexpramipexole dihydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$148
Updated
2022/05/15
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Pramipexole Impurity 16 Chemical Properties,Usage,Production

Description

Pramipexole (Item No. 11981) is an agonist of dopamine receptors that has applications in Parkinson’s disease and other disorders. Pramipexole is usually available as a mixture of enantiomers, with the majority of the dopamine receptor-dependent activity resulting from the (S) form. (R)-Pramipexole is an enantiomer of pramipexole that is ~100-fold less active than the (S) form as a dopamine receptor agonist. For this reason, it can be used as a negative control for the (S) form in the study of dopamine receptors. Both isoforms are antioxidants that target mitochondria to prevent apoptosis. This cytoprotective effect of (R)-pramipexole, without dopaminergic side effects, suggests utility in amyotrophic lateral sclerosis.

Uses

(R)-Pramipexole Dihydrochloride (Pramipexole EP Impurity D; Pramipexole BP Impurity D; Pramipexole USP Related Compound D) is the opposite enantiomer of Pramipexole (P700755), a dopamine-D2-receptor agonist. Dexpramipexole is a low-molecular-weight, water-soluble, orally bioavailable, renally excreted compound with linear pharmacokinetics.

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Pramipexole may be used as a secondary pharma standard for the determination of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography and ultraviolet spectrophotometry technique.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Pramipexole Related Compound D is a pharmaceutical impurity of pramipexole. Pramipexole is a non-ergot dopamine receptor agonist, widely used in the treatment of Parkinson′s disease.

Biochem/physiol Actions

R-(+)-Pramipexole is a neuroprotective agent; weak non-ergoline dopamine agonist. R-(+)-Pramipexole has been found to have neuroprotective effects and is being investigated for treatment of ALS. It reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, R-(+)-Pramipexole has much lower dopamine agonist activity.

Pramipexole Impurity 16 Preparation Products And Raw materials

Raw materials

Preparation Products

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Pramipexole Impurity 16 Suppliers

BOC Sciences
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1-631-485-4226; 16314854226
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United States
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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+1 (866) 930-6790
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+1 (866) 333-9607
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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InvivoChem
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Cayman Chemical Company
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View Lastest Price from Pramipexole Impurity 16 manufacturers

Guangzhou PI PI BIOTECH INC
Product
Pramipexole Impurity D
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
90%+
Supply Ability
10g
Release date
2020-06-01

104632-27-1, Pramipexole Impurity 16Related Search:


  • (R)-PRAMIPEXOLE DIHYDROCHLORIDE; KNS 760704; SND 919CL2X
  • Pramipexole R-Isomer
  • 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, (R)-
  • Kns 760704
  • Snd 919cl2x
  • DexpraMipexole (dihydrochloride)
  • PraMipexole IMpurity D
  • (R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride // (R)-Pramipexole dihydrochloride
  • (R)-4,5,6,7-Tetrahydro-6-(propylamino)-benzothiazole-2-amine dihydrochloride
  • RPPX
  • Pramipexole Dihydrochloride Hydrate Impurity
  • (R)-Pramipexole (hydrochloride)
  • Pramipexole Dihydrochloride Hydrate IMP
  • Pramipexole EP Impurity D DiHCl
  • Pramipexole dihydrochloride impurity IV
  • (6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine,dihydrochloride
  • Dexpramipexole dihydrochloride ((R)-Pramipexole
  • Pramipexole impurity D CRS
  • KNS-760704 dihydrochloride
  • (R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride
  • Dexpramipexole HCl
  • Pramipexole EP Impurity D ((R)-Pramipexole diHCl)
  • Pramipexole Related Compound D ((R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydro (1553815)
  • Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride
  • Dopamine Receptor,inhibit,Inhibitor,KNS-760704,Dexpramipexole,Dexpramipexole dihydrochloride,(R)-Pramipexole,KNS760704,KNS 760704
  • Pramipexole Impurity 4 Dihydrochloride(Pramipexole EP Impurity D Dihydrochloride)
  • Dexpramipexole 2HCl
  • Glycerol Impurity 41((R)-3-chloropropane-1,2-diol)
  • Pramipexole BP Impurity D
  • Pramipexole EP Impurity D HCl
  • Pramipexole Impurity D (R-Isomer)
  • 104632-27-1
  • 28425