TERT-BUTYL (3-IODOPROPYL)CARBAMATE
- Product Name
- TERT-BUTYL (3-IODOPROPYL)CARBAMATE
- CAS No.
- 167479-01-8
- Chemical Name
- TERT-BUTYL (3-IODOPROPYL)CARBAMATE
- Synonyms
- tert-Butyl (3-iodopropyl);N-Boc-3-iodo-1-propylamine;TERT-BUTYL (3-IODOPROPYL)CARBAMATE;tert-butyl N-(3-iodopropyl)carbamate;tert-Butyl 3-iodopropylcarbamate - [B8387];N-(3-Iodopropyl)carbamic acid tert-butyl ester;1,1-Dimethylethyl Ester N-(3-Iodopropyl)carbamic Acid;Carbamic Acid, N-(3-Iodopropyl)-, 1,1-Dimethylethyl Ester
- CBNumber
- CB82453008
- Molecular Formula
- C8H16INO2
- Formula Weight
- 285.12
- MOL File
- 167479-01-8.mol
TERT-BUTYL (3-IODOPROPYL)CARBAMATE Property
- Melting point:
- 37-40 °C
- Boiling point:
- 299.3±23.0 °C(Predicted)
- Density
- 1.486±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.54±0.46(Predicted)
- color
- Pale Yellow
Safety
- HS Code
- 2921199990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C183613
- Product name
- 1,1-DimethylethylEsterN-(3-Iodopropyl)carbamicAcid
- Packaging
- 500mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- Y7770
- Product name
- tert-Butyl3-iodopropylcarbamate
- Packaging
- 1g
- Price
- $209
- Updated
- 2021/12/16
- Product number
- CS-0046940
- Product name
- tert-Butyl(3-iodopropyl)carbamate
- Packaging
- 5g
- Price
- $214
- Updated
- 2021/12/16
- Product number
- OR962795
- Product name
- tert-ButylN-(3-iodopropyl)carbamate
- Purity
- 96%
- Packaging
- 1g
- Price
- $254
- Updated
- 2021/12/16
- Product number
- B8387
- Product name
- tert-Butyl3-iodopropylcarbamate
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
TERT-BUTYL (3-IODOPROPYL)CARBAMATE Chemical Properties,Usage,Production
Uses
1,1-Dimethylethyl Ester N-(3-Iodopropyl)carbamic Acid is used in preparation of isoindolin-2-one-linked quinazoline and pyridopyrimidine as Ras protein degraders and anticancer agents.
Synthesis
58885-58-8
167479-01-8
General procedure for the synthesis of tert-butyl (3-iodopropyl) carbamate from tert-butyl N-(3-hydroxypropyl) carbamate: firstly, 3-amino-1-propanol (3.22 mL, 40 mmol) was dissolved in 50 mL of dichloromethane (CH2Cl2), triethylamine (Et3N, 5.6 mL, 40 mmol) was added, and stirred for 30 min. Subsequently, a solution of pre-dissolved di-tert-butyl dicarbonate (Boc2O, 9.6 g, 44 mmol) in 50 mL of CH2Cl2 was slowly added and the reaction mixture was stirred at room temperature for 14 hours. After completion of the reaction, saturated aqueous ammonium chloride solution (30 mL) was added and the mixture was extracted with CH2Cl2 (3 x 20 mL). The organic phases were combined, dried and concentrated to give the crude product (6.00 g, 86% yield), which was used directly in the next step of the reaction. Next, 1H-imidazole (1.4 g, 20.57 mmol) and triphenylphosphine (5.39 g, 20.57 mmol) were dissolved in 100 mL of CH2Cl2 and cooled to 0 °C before adding iodine (I2, 5.22 g, 20.57 mmol) in small portions. Then, a solution of the crude product (3.0 g, 17.14 mmol) obtained in the previous step dissolved in 20 mL CH2Cl2 was added. The reaction mixture was stirred for 3 h at room temperature and then poured into water (100 mL) and extracted with CH2Cl2 (50 mL). The organic phase was washed sequentially with water, 10% hydrochloric acid solution (12 mL), then extracted with CH2Cl2 (3 x 50 mL), dried and concentrated. Finally, the target product tert-butyl (3-iodopropyl)carbamate (3.78 g, 78% yield) was purified by fast chromatography (silica gel, 15% ethyl acetate/petroleum ether) as a light yellow oil.
References
[1] Journal of Organic Chemistry, 2009, vol. 74, # 17, p. 6792 - 6796
[2] Journal of Organic Chemistry, 2009, vol. 74, # 20, p. 7982 - 7985
[3] Helvetica Chimica Acta, 2002, vol. 85, # 6, p. 1659 - 1673
[4] Helvetica Chimica Acta, 2003, vol. 86, # 1, p. 233 - 246
[5] Angewandte Chemie - International Edition, 2011, vol. 50, # 23, p. 5379 - 5382
TERT-BUTYL (3-IODOPROPYL)CARBAMATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from TERT-BUTYL (3-IODOPROPYL)CARBAMATE manufacturers
- Product
- TERT-BUTYL (3-IODOPROPYL)CARBAMATE 167479-01-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19