ChemicalBook > CAS DataBase List > TERT-BUTYL (3-IODOPROPYL)CARBAMATE

TERT-BUTYL (3-IODOPROPYL)CARBAMATE

Product Name: TERT-BUTYL (3-IODOPROPYL)CARBAMATE
CAS No.: 167479-01-8
Chemical Name: TERT-BUTYL (3-IODOPROPYL)CARBAMATE
Synonyms: tert-Butyl (3-iodopropyl);N-Boc-3-iodo-1-propylamine;TERT-BUTYL (3-IODOPROPYL)CARBAMATE;tert-butyl N-(3-iodopropyl)carbamate;tert-Butyl 3-iodopropylcarbamate - [B8387];N-(3-Iodopropyl)carbamic acid tert-butyl ester;1,1-Dimethylethyl Ester N-(3-Iodopropyl)carbamic Acid;Carbamic Acid, N-(3-Iodopropyl)-, 1,1-Dimethylethyl Ester
CBNumber: CB82453008
Molecular Formula: C8H16INO2
Formula Weight: 285.12
MOL File: 167479-01-8.mol

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TERT-BUTYL (3-IODOPROPYL)CARBAMATE Property

Melting point:: 37-40 °C
Boiling point:: 299.3±23.0 °C(Predicted)
Density: 1.486±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 12.54±0.46(Predicted)
color: Pale Yellow

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Safety

HS Code: 2921199990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C183613
Product name: 1,1-DimethylethylEsterN-(3-Iodopropyl)carbamicAcid
Packaging: 500mg
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: Y7770
Product name: tert-Butyl3-iodopropylcarbamate
Packaging: 1g
Price: $209
Updated: 2021/12/16

ChemScene

Product number: CS-0046940
Product name: tert-Butyl(3-iodopropyl)carbamate
Packaging: 5g
Price: $214
Updated: 2021/12/16

Apolloscientific

Product number: OR962795
Product name: tert-ButylN-(3-iodopropyl)carbamate
Purity: 96%
Packaging: 1g
Price: $254
Updated: 2021/12/16

Synthonix

Product number: B8387
Product name: tert-Butyl3-iodopropylcarbamate
Purity: 97.0%
Packaging: 1g
Price: $120
Updated: 2021/12/16

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TERT-BUTYL (3-IODOPROPYL)CARBAMATE Chemical Properties,Usage,Production

Uses

1,1-Dimethylethyl Ester N-(3-Iodopropyl)carbamic Acid is used in preparation of isoindolin-2-one-linked quinazoline and pyridopyrimidine as Ras protein degraders and anticancer agents.

Synthesis

58885-58-8

167479-01-8

General procedure for the synthesis of tert-butyl (3-iodopropyl) carbamate from tert-butyl N-(3-hydroxypropyl) carbamate: firstly, 3-amino-1-propanol (3.22 mL, 40 mmol) was dissolved in 50 mL of dichloromethane (CH2Cl2), triethylamine (Et3N, 5.6 mL, 40 mmol) was added, and stirred for 30 min. Subsequently, a solution of pre-dissolved di-tert-butyl dicarbonate (Boc2O, 9.6 g, 44 mmol) in 50 mL of CH2Cl2 was slowly added and the reaction mixture was stirred at room temperature for 14 hours. After completion of the reaction, saturated aqueous ammonium chloride solution (30 mL) was added and the mixture was extracted with CH2Cl2 (3 x 20 mL). The organic phases were combined, dried and concentrated to give the crude product (6.00 g, 86% yield), which was used directly in the next step of the reaction. Next, 1H-imidazole (1.4 g, 20.57 mmol) and triphenylphosphine (5.39 g, 20.57 mmol) were dissolved in 100 mL of CH2Cl2 and cooled to 0 °C before adding iodine (I2, 5.22 g, 20.57 mmol) in small portions. Then, a solution of the crude product (3.0 g, 17.14 mmol) obtained in the previous step dissolved in 20 mL CH2Cl2 was added. The reaction mixture was stirred for 3 h at room temperature and then poured into water (100 mL) and extracted with CH2Cl2 (50 mL). The organic phase was washed sequentially with water, 10% hydrochloric acid solution (12 mL), then extracted with CH2Cl2 (3 x 50 mL), dried and concentrated. Finally, the target product tert-butyl (3-iodopropyl)carbamate (3.78 g, 78% yield) was purified by fast chromatography (silica gel, 15% ethyl acetate/petroleum ether) as a light yellow oil.

References

[1] Journal of Organic Chemistry, 2009, vol. 74, # 17, p. 6792 - 6796
[2] Journal of Organic Chemistry, 2009, vol. 74, # 20, p. 7982 - 7985
[3] Helvetica Chimica Acta, 2002, vol. 85, # 6, p. 1659 - 1673
[4] Helvetica Chimica Acta, 2003, vol. 86, # 1, p. 233 - 246
[5] Angewandte Chemie - International Edition, 2011, vol. 50, # 23, p. 5379 - 5382

TERT-BUTYL (3-IODOPROPYL)CARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TERT-BUTYL (3-IODOPROPYL)CARBAMATE manufacturers

Career Henan Chemical Co

Product: TERT-BUTYL (3-IODOPROPYL)CARBAMATE 167479-01-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

167479-01-8, TERT-BUTYL (3-IODOPROPYL)CARBAMATERelated Search:

3(S)-IODOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL (3-IODOPROPYL)CARBAMATE N-Boc-4-iodopiperidine BOC-TRANS-4-IODO-L-PROLINE tert-Butyl 3-(iodomethyl)pyrrolidine-1-carboxylate N-BOC-TRANS-4-IODO-L-PROLINE METHYL ESTER TERT-BUTYL 3-(IODOMETHYL)AZETIDINE-1-CARBOXYLATE 3(R)-IODOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-N-BOC-3-IODOMETHYLPIPERIDINE

Carbamic Acid, N-(3-Iodopropyl)-, 1,1-Dimethylethyl Ester

N-(3-Iodopropyl)carbamic acid tert-butyl ester

TERT-BUTYL (3-IODOPROPYL)CARBAMATE

tert-Butyl (3-iodopropyl)

1,1-Dimethylethyl Ester N-(3-Iodopropyl)carbamic Acid

N-Boc-3-iodo-1-propylamine

tert-butyl N-(3-iodopropyl)carbamate

tert-Butyl 3-iodopropylcarbamate - [B8387]

167479-01-8

C8H16INO2