N-Boc-4-iodopiperidine

Product Name: N-Boc-4-iodopiperidine
CAS No.: 301673-14-3
Chemical Name: N-Boc-4-iodopiperidine
Synonyms: tert-butyl 4-iodopiperidine-1-carboxylate;1-Boc-4-iodopiperidine;N-Boc-iodopiperidine;N-BOC-4-IODO-PIPERIDINE;1-Boc-4-iodopiperidine,95%;1-Boc-4-Iodo-Piperidine,97%;4-Iodopiperidine, N-BOC protected;4-Iodopiperidine, N-BOC protected 97%;ert-butyl4-iodopiperidine-1-carboxylate;1-(TERT-BUTOXYCARBONYL)-4-IODOPIPERIDINE
CBNumber: CB1246852
Molecular Formula: C10H18INO2
Formula Weight: 311.16
MOL File: 301673-14-3.mol

More

Less

N-Boc-4-iodopiperidine Property

Melting point:: 35-38°
Boiling point:: 318.8±35.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
pka: -2.54±0.40(Predicted)
form: Crystalline Powder or Low Melting Solid
color: White to pale brown
Water Solubility: Slightly soluble in water. Soluble in methanol.
Sensitive: Light Sensitive
InChI: InChI=1S/C10H18INO2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7H2,1-3H3
InChIKey: YFWQFKUQVJNPKP-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(I)CC1
CAS DataBase Reference: 301673-14-3

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 22-26-36/37/39
HazardClass: IRRITANT
HS Code: 29389090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B4164
Product name: 1-tert-Butoxycarbonyl-4-iodopiperidine
Purity: >97.0%(GC)
Packaging: 1g
Price: $35
Updated: 2025/07/31

TCI Chemical

Product number: B4164
Product name: 1-tert-Butoxycarbonyl-4-iodopiperidine
Purity: >97.0%(GC)
Packaging: 5g
Price: $96
Updated: 2025/07/31

Matrix Scientific

Product number: 047825
Product name: tert-Butyl 4-iodotetrahydro-1(2H)-pyridinecarboxylate
Purity: >95%
Packaging: 1g
Price: $10
Updated: 2021/12/16

Oakwood

Product number: 067527
Product name: tert-Butyl 4-Iodopiperidine-1-carboxylate
Packaging: 1g
Price: $20
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK289758
Product name: N-Boc-4-iodo-piperidine
Purity: 98%
Packaging: 250mg
Price: $34
Updated: 2021/12/16

More

Less

N-Boc-4-iodopiperidine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Used in the coupling reaction in Iron-and Cobalt-Catalyzed Arylation of Azetidines, Pyrrolidines, and Piperidines with Grignard Reagents.

Synthesis

109384-19-2

301673-14-3

The general procedure for the synthesis of N-Boc-4-iodopiperidine from N-Boc-4-hydroxypiperidine was as follows: to a solution of N-Boc-4-hydroxypiperidine (10.0 g, 49.7 mmol) in dichloromethane (200 mL) was added triphenylphosphine (16.9 g, 64.6 mmol) and imidazole (5.07 g, 74.5 mmol) sequentially. After the reaction mixture was cooled to 0°C in an ice bath, iodine (15.1 g, 59.6 mmol) was added slowly in portions. After addition, the reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the reaction solution was diluted with water and extracted with ether. The organic layers were combined, washed sequentially with water and saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was ground with hexane to remove excess triphenylphosphine and triphenylphosphine oxide. After filtration, the filtrate was concentrated under reduced pressure to afford the target product N-Boc-4-iodopiperidine as a colorless oil (14.4 g, 93% yield).

References

[1] Patent: US2005/9838, 2005, A1. Location in patent: Page 143
[2] Patent: WO2018/106636, 2018, A1. Location in patent: Paragraph 00283
[3] Patent: WO2011/143366, 2011, A1. Location in patent: Page/Page column 45
[4] Journal of Organic Chemistry, 2004, vol. 69, # 15, p. 5120 - 5123
[5] Synlett, 1998, # 4, p. 379 - 380

N-Boc-4-iodopiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-Boc-4-iodopiperidine Suppliers

Americas 1 Belgium 1 China 158 Europe 1 France 1 Germany 2 India 7 Japan 1 Switzerland 1 United Kingdom 7 United States 31 Global 211

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928 18796809688
Fax: 0512-68417696
Email: zhouyingxiang@highfine.com
Country: China
ProdList: 475
Advantage: 75

Shanghai Hobor Chemical Co., Ltd

Tel: 021-57790084; 13918007836
Fax: 021-51685238
Email: sales@hoborchem.com
Country: China
ProdList: 392
Advantage: 60

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

More

Less

View Lastest Price from N-Boc-4-iodopiperidine manufacturers

Career Henan Chemical Co

Product: N-Boc-4-iodopiperidine 301673-14-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 500kg
Release date: 2018-08-17

301673-14-3, N-Boc-4-iodopiperidineRelated Search:

Butyl acetate Methyl 4-tert-butylbenzoate Tris(trimethylsilyl)phosphate tert-Butanol Isobutyl chloroformate Diisobutyl phthalate 2-Butoxyethanol Triacetonediamine DROPERIDOL Butylparaben Buprofezin 2-Iodobenzoic acid tert-Butyl carbazate Methyl acrylate Haloperidol Butyl acrylate DI-TERT-BUTYL ETHER N-BOC-3-Aminopiperidine

N-BOC-4-IODO-PIPERIDINE

1-(TERT-BUTOXYCARBONYL)-4-IODOPIPERIDINE

4-Iodopiperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-iodopiperidine-1-carboxylate(SALTDATA: FREE)

tert-butyl 4-iodopiperidine-1-carboxylate

N-Boc-iodopiperidine

1-(tert-Butoxycarbonyl)-4-iodopiperidine, tert-Butyl 4-iodopiperidine-1-carboxylate

4-Iodopiperidine, N-BOC protected

1-<i>tert</i>-Butoxycarbonyl-4-iodopiperidine

1-Piperidinecarboxylicacid, 4-iodo-, 1,1-dimethylethyl ester

1-Boc-4-iodopiperidine

1-Boc-4-Iodo-Piperidine,97%

4-Iodopiperidine, N-BOC protected 97%

1-tert-Butoxycarbonyl-4-iodopiperidine &gt

1-Boc-4-iodopiperidine,95%

ert-butyl4-iodopiperidine-1-carboxylate

4-Iodo-1-piperidinecarboxylic Acid tert-Butyl Ester

tert-Butyl 4-Iodo-1-piperidinecarboxylate

Octanedioicacid,3,9-dioxo-,dimethylester

Tert-Butyl 4-Iodopiperidine-1-Carboxylat

301673-14-3

C10H18INO2

pharmacetical

Heterocyclic Building Blocks