ChemicalBook > CAS DataBase List > N-Boc-4-iodopiperidine

N-Boc-4-iodopiperidine

Product Name
N-Boc-4-iodopiperidine
CAS No.
301673-14-3
Chemical Name
N-Boc-4-iodopiperidine
Synonyms
tert-butyl 4-iodopiperidine-1-carboxylate;1-Boc-4-iodopiperidine;N-Boc-iodopiperidine;N-BOC-4-IODO-PIPERIDINE;1-Boc-4-iodopiperidine,95%;1-Boc-4-Iodo-Piperidine,97%;4-Iodopiperidine, N-BOC protected;4-Iodopiperidine, N-BOC protected 97%;ert-butyl4-iodopiperidine-1-carboxylate;1-(TERT-BUTOXYCARBONYL)-4-IODOPIPERIDINE
CBNumber
CB1246852
Molecular Formula
C10H18INO2
Formula Weight
311.16
MOL File
301673-14-3.mol
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N-Boc-4-iodopiperidine Property

Melting point:
35-38°
Boiling point:
318.8±35.0 °C(Predicted)
Density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
pka
-2.54±0.40(Predicted)
form 
Crystalline Powder or Low Melting Solid
color 
White to pale brown
Water Solubility 
Slightly soluble in water. Soluble in methanol.
Sensitive 
Light Sensitive
InChI
InChI=1S/C10H18INO2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7H2,1-3H3
InChIKey
YFWQFKUQVJNPKP-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(I)CC1
CAS DataBase Reference
301673-14-3
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
22-26-36/37/39
HazardClass 
IRRITANT
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4164
Product name
1-tert-Butoxycarbonyl-4-iodopiperidine
Purity
>97.0%(GC)
Packaging
1g
Price
$35
Updated
2025/07/31
TCI Chemical
Product number
B4164
Product name
1-tert-Butoxycarbonyl-4-iodopiperidine
Purity
>97.0%(GC)
Packaging
5g
Price
$96
Updated
2025/07/31
Matrix Scientific
Product number
047825
Product name
tert-Butyl 4-iodotetrahydro-1(2H)-pyridinecarboxylate
Purity
>95%
Packaging
1g
Price
$10
Updated
2021/12/16
Oakwood
Product number
067527
Product name
tert-Butyl 4-Iodopiperidine-1-carboxylate
Packaging
1g
Price
$20
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK289758
Product name
N-Boc-4-iodo-piperidine
Purity
98%
Packaging
250mg
Price
$34
Updated
2021/12/16
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N-Boc-4-iodopiperidine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Used in the coupling reaction in Iron-and Cobalt-Catalyzed Arylation of Azetidines, Pyrrolidines, and Piperidines with Grignard Reagents.

Synthesis

109384-19-2

301673-14-3

The general procedure for the synthesis of N-Boc-4-iodopiperidine from N-Boc-4-hydroxypiperidine was as follows: to a solution of N-Boc-4-hydroxypiperidine (10.0 g, 49.7 mmol) in dichloromethane (200 mL) was added triphenylphosphine (16.9 g, 64.6 mmol) and imidazole (5.07 g, 74.5 mmol) sequentially. After the reaction mixture was cooled to 0°C in an ice bath, iodine (15.1 g, 59.6 mmol) was added slowly in portions. After addition, the reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the reaction solution was diluted with water and extracted with ether. The organic layers were combined, washed sequentially with water and saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was ground with hexane to remove excess triphenylphosphine and triphenylphosphine oxide. After filtration, the filtrate was concentrated under reduced pressure to afford the target product N-Boc-4-iodopiperidine as a colorless oil (14.4 g, 93% yield).

References

[1] Patent: US2005/9838, 2005, A1. Location in patent: Page 143
[2] Patent: WO2018/106636, 2018, A1. Location in patent: Paragraph 00283
[3] Patent: WO2011/143366, 2011, A1. Location in patent: Page/Page column 45
[4] Journal of Organic Chemistry, 2004, vol. 69, # 15, p. 5120 - 5123
[5] Synlett, 1998, # 4, p. 379 - 380

N-Boc-4-iodopiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-4-iodopiperidine Suppliers

Americas 1 Belgium 1 China 158 Europe 1 France 1 Germany 2 India 7 Japan 1 Switzerland 1 United Kingdom 7 United States 31 Global 211
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View Lastest Price from N-Boc-4-iodopiperidine manufacturers

Career Henan Chemical Co
Product
N-Boc-4-iodopiperidine 301673-14-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
500kg
Release date
2018-08-17

301673-14-3, N-Boc-4-iodopiperidineRelated Search:

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  • N-BOC-4-IODO-PIPERIDINE
  • 1-(TERT-BUTOXYCARBONYL)-4-IODOPIPERIDINE
  • 4-Iodopiperidine-1-carboxylic acid tert-butyl ester
  • tert-butyl 4-iodopiperidine-1-carboxylate(SALTDATA: FREE)
  • tert-butyl 4-iodopiperidine-1-carboxylate
  • N-Boc-iodopiperidine
  • 1-(tert-Butoxycarbonyl)-4-iodopiperidine, tert-Butyl 4-iodopiperidine-1-carboxylate
  • 4-Iodopiperidine, N-BOC protected
  • 1-<i>tert</i>-Butoxycarbonyl-4-iodopiperidine
  • 1-Piperidinecarboxylicacid, 4-iodo-, 1,1-dimethylethyl ester
  • 1-Boc-4-iodopiperidine
  • 1-Boc-4-Iodo-Piperidine,97%
  • 4-Iodopiperidine, N-BOC protected 97%
  • 1-tert-Butoxycarbonyl-4-iodopiperidine &gt
  • 1-Boc-4-iodopiperidine,95%
  • ert-butyl4-iodopiperidine-1-carboxylate
  • 4-Iodo-1-piperidinecarboxylic Acid tert-Butyl Ester
  • tert-Butyl 4-Iodo-1-piperidinecarboxylate
  • Octanedioicacid,3,9-dioxo-,dimethylester
  • Tert-Butyl 4-Iodopiperidine-1-Carboxylat
  • 301673-14-3
  • C10H18INO2
  • pharmacetical
  • Heterocyclic Building Blocks