PI-103

ChemicalBook > CAS DataBase List > PI-103

Product Name: PI-103
CAS No.: 371935-74-9
Chemical Name: PI-103
Synonyms: PI-103;PI 103;PI 103 HYDROCHLORIDE;PI-103, Free Base, >99%;PI-103HydrochlorideSalt;PI-103 - CAS 371935-74-9 - Calbiochem;PI 3-Kinase Inhibitor (PI-103) B-0303;PI-103, 98%, a potent PI3K/Akt and mTOR inhibitor;3-(4-Morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol;3-(4-Morpholinopyrido[3',2':4,5] furo[3,2-d]pyriMidin-2-yl)phenol;3-[4-(4-Morpholinylpyrido[3',2',4,5]furo[3,2-d]pyrimidin-2-yl]phenol
CBNumber: CB82454333
Molecular Formula: C19H16N4O3
Formula Weight: 348.36
MOL File: 371935-74-9.mol

Less

PI-103 Property

Density: 1.409±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 40 mg/ml)
form: White solid
pka: 9.06±0.10(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 528100
Product name: PI-103 - CAS 371935-74-9 - Calbiochem<br />A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR.
Packaging: 1mg
Price: $172
Updated: 2024/03/01

Sigma-Aldrich

Product number: 528100
Product name: PI-103 - CAS 371935-74-9 - Calbiochem<br />A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR.
Packaging: 5mg
Price: $632
Updated: 2024/03/01

Cayman Chemical

Product number: 10009209
Product name: PI-103
Purity: ≥98%
Packaging: 1mg
Price: $30
Updated: 2024/03/01

Cayman Chemical

Product number: 10009209
Product name: PI-103
Purity: ≥98%
Packaging: 5mg
Price: $113
Updated: 2024/03/01

Cayman Chemical

Product number: 10009209
Product name: PI-103
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Less

PI-103 Chemical Properties,Usage,Production

Description

PI-103 (371935-74-9) is a potent inhibitor of PI-3 kinase, mTOR and DNA-PK, IC50 = 8, 88, 150, 48,? 20, 83 and 2 nM for p110α, p110?, p110γ, p110δ, mTORC1, mTORC2 and DNA-PK respectively.1,2 Synergizes with arsenic disulfide to eradicate AML stem cells by induction of differentiation.3 Inhibits the growth of gefitinib-resistant non-small cell lung cancer cell lines.4 Induces autophagy in drug-resistant glioma.5 Protects against a-synuclein-induced toxicity in human neurons by induction of macroautophagy.6

Uses

PI 103 is a dual inhbitor of Class IA phosphatidylinositol 3-kinase and mammalian target of rapaymycin complex 1 (mTORC1), both of which are involved in pathways often activated in myelogenous leukemia. PI 103 also functions to enhance tumour radiosensitivity.

Definition

ChEBI: An organic heterotricyclic compound that is pyrido[3',2':4,5]furo[3,2-d]pyrimidine substituted at positions 2 and 4 by 3-hydroxyphenyl and morpholin-4-yl groups respectively. A dual-kinase inhibitor with anti-cancer properties.

General Description

A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC₅₀ = 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110δ, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC₅₀ = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 μM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo. A 10 mM (2 mg/574 μl) solution of PI-103 (Cat. No. 528101) in DMSO is also available.

Biological Activity

Inhibitor of DNA-PK, PI 3-kinase (p110 α ) and mTOR (IC 50 values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110 α , mTORC1, PI3KC2 β , p110 δ , mTORC2, p110 β , p110 γ , ATR, ATM, PI3KC2 α and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice in vivo .

Biochem/physiol Actions

Cell permeable: yes

target

Cell, 2013, 153(4):840-54

References

Knight et al. (2006), A Pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling; Cell, 125 733 Raynaud et al. (2007), Pharmacologic characterization of a potent inhibitor of a class I phosphatidylinositide 3-kinases; Cancer Res., 67 5840 Hong et al. (2011), Arsenic disulfide synergizes with the phosphoinositide 3-kinase inhibitor PI-103 to eradicate acute myeloid leukemia stem cells by inducing differentiation; Carcinogenesis, 32 1550 Zou et al. (2009), A novel dual PI3Kalpha/mTOR inhibitor PI-103 with high antitumor activity in non-small cell lung cancer cells; Int. J. Mol. Med. 24 97 Fan et al. (2010), Akt and autophagy cooperate to promote survival of drug-resistant glioma; Sci. Signal., 3 ra81 Hollerhage et al. (2019), Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons; Neuropharmacology, 149 13

PI-103 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

PI-103 Suppliers

China 131 Germany 1 India 1 The Netherlands 1 United Kingdom 2 United States 25 Global 161

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1836
Advantage: 55

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 982
Advantage: 56

Shangchem Co., Ltd.

Tel: +86-21-68182121
Fax: +86-21-68182121
Country: China
ProdList: 882
Advantage: 52

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 18089
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15421
Advantage: 60

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Xi’an chemsoar Medical Technology Co., ltd

Tel: 029-86538357
Fax: 029-87871708
Country: China
ProdList: 234
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4659
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9872
Advantage: 52

Nanjing JinruiJiuAn Biotechnology Co., Ltd.

Tel: 025-58196018 800028039
Fax: 025-83453306
Email: sales@fartop.net
Country: China
ProdList: 2231
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9449
Advantage: 58

Chengdu NoVi Biotechnology Co., Ltd.

Tel: 028-81458053
Fax: 028-81458053
Email: novibiotech@163.com sales@novi-biotech.com
Country: China
ProdList: 226
Advantage: 55

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1494
Advantage: 55

China Kouting Group Limited

Tel: +86 (21) 5811-6473 5811-6475
Fax: +86 (21) 6129-4103
Email: sales@koutingchina.com
Country: China
ProdList: 496
Advantage: 60

SYN|thesis med chem P/L

Tel: +86-021-50720296
Fax: +86-021-50720297
Email: service@synkinase.com
Country: China
ProdList: 266
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25014
Advantage: 65

Moltt Biocem Co., Ltd.

Tel: +86-21-38682181 15900741819
Fax: +86-21-38682181
Country: China
ProdList: 282
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

GIHI CHEMICALS CO.,LTD

Tel: 0086-571-86217390
Fax: 0086-571-86217391
Email: Sales@gihichem.com
Country: China
ProdList: 861
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3423
Advantage: 58

Suzhou Laing Biological Technology Co., LTD

Tel: 0512-62968256 18550502935
Fax: 0512-62968256
Email: export@laingbiotec.com
Country: China
ProdList: 1043
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9767
Advantage: 58

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9972
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
Advantage: 55

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 7059
Advantage: 55

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6508
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9254
Advantage: 55

Shanghai Universe International trade Co.,Ltd

Tel: 17317567081
Email: info@coreuni.com
Country: China
ProdList: 201
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9934
Advantage: 55

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: order@changyanchem.com
Country: China
ProdList: 5008
Advantage: 55

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9604
Advantage: 55

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20810
Advantage: 60

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14623
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6357
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9756
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29797
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Shanghai Resuperpharmtech Co., Ltd.

Tel: 17321237488
Email: kevin@resuperpharmtech.com
Country: China
ProdList: 368
Advantage: 58

Less

View Lastest Price from PI-103 manufacturers

Career Henan Chemical Co

Product: PI-103 371935-74-9
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

371935-74-9, PI-103Related Search:

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide AZ20 Ibrutinib BI 2536 TRICHOSTATIN A MK-2206 2HCl Trametinib LY 294002 HYDROCHLORIDE Rapamycin BEZ235 (NVP-BEZ235, Dactolisib) PI-103

Phenol, 3-[4-(4-Morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyriMidin-2-yl]-

3-(4-Morpholinopyrido[3',2':4,5] furo[3,2-d]pyriMidin-2-yl)phenol

PI 3-Kinase Inhibitor (PI-103) B-0303

PI-103, Free Base, >99%

PI-103 - CAS 371935-74-9 - Calbiochem

PI-103HydrochlorideSalt

3-[4-(4-Morpholinylpyrido[3',2',4,5]furo[3,2-d]pyrimidin-2-yl]phenol

3-(4-morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol hydrochloride

3-[4-(4-Morpholinylpyrido[3',2',4,5]furo[3,2-d]pyrimidin-2-yl]phenol PI 103

PI 103 3-[4-(4-Morpholinylpyrido[3',2',4,5]furo[3,2-d]pyrimidin-2-yl]phenol

PI-103;PI 103

PI 103 HYDROCHLORIDE

3-[4-Morpholin-4-ylpyrido[3',2':4,5]furo[3,2-d]pyriMidin-2-yl]phenol

PI-103, 98%, a potent PI3K/Akt and mTOR inhibitor

3-[4-(4-MORPHOLINYLPYRIDO)[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL]PHENOL HYDROCHLORIDE

3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaen-4-yl]phenol

PI3K,Phosphoinositide 3-kinase,Inhibitor,DNA-PK,Apoptosis,Autophagy,DNA-dependent protein kinase,inhibit,PI-103,Mammalian target of Rapamycin,mTOR

3-(4-Morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol

371935-74-9

C19H16N4O3HCl

Akt

mTOR

PI3K

Inhibitors