2-AMINO-3,5-DICHLOROPYRAZINE
- Product Name
- 2-AMINO-3,5-DICHLOROPYRAZINE
- CAS No.
- 873-42-7
- Chemical Name
- 2-AMINO-3,5-DICHLOROPYRAZINE
- Synonyms
- 3,5-dichloropyrazin-2-aMine;3,5-Dichloro-pyrazin-2-ylamine;3,5-Dichloro-2-PyrazinaMine;2-AMini-3,5-dichloropyrazine;2-PyrazinaMine,3,5-dichloro-;3,5-Dichloro-2-aminopyrazine;2-Dmino-3,5-dichloropyrazine;2-AMINO-3,5-DICHLOROPYRAZINE;2-AMino-3,5-dichloropyrazine, 95+%;2-AMINO-3,5-DICHLOROPYRAZINE ISO 9001：2015 REACH
- CBNumber
- CB82455219
- Molecular Formula
- C4H3Cl2N3
- Formula Weight
- 163.99
- MOL File
- 873-42-7.mol
2-AMINO-3,5-DICHLOROPYRAZINE Property
- Melting point:
- 140-142 °C
- Boiling point:
- 275.6±35.0 °C(Predicted)
- Density
- 1.606±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 0.89±0.10(Predicted)
- Appearance
- Light brown to yellow Solid
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D436135
- Product name
- 3,5-Dichloro-2-pyrazinamine
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FA72035
- Product name
- 2-Amino-3,5-dichloropyrazine
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- J91190
- Product name
- 2-Amino-3,5-dichloropyrazine
- Packaging
- 25g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FA72035
- Product name
- 2-Amino-3,5-dichloropyrazine
- Packaging
- 2g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 072542
- Product name
- 2-Amino-3,5-dichloropyrazine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $58
- Updated
- 2021/12/16
2-AMINO-3,5-DICHLOROPYRAZINE Chemical Properties,Usage,Production
Uses
3,5-Dichloro-2-pyrazinamine is used in the synthesis of pyrazinones as inhibitors of protein kinases, which play a key role in the progression of cancer. It is also used in the synthesis of N-substituted pyrazines by tandem reaction ofo-aminohalopyrazines with isothiocyanates.
Synthesis
6863-73-6
873-42-7
General procedure for the synthesis of 3,5-dichloropyrazin-2-amine from 2-amino-3-chloropyrazine: 2-amino-3-chloropyrazine (10.0 g, 77.2 mmol) was added to a stirred suspension of N-chlorosuccinimide (NCS, 11.6 g, 86.9 mmol) in chloroform (73 mL). The reaction mixture was heated to reflux for 4 hours. Upon completion of the reaction, the solution was cooled to room temperature and partitioned between chloroform (180 mL) and water (2 x 50 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using chloroform as eluent to afford 3,5-dichloropyrazin-2-amine (9.66 g, 76% yield) as a light yellow solid. The product characterization data were as follows: melting point 200-202°C; thin layer chromatography Rf value (CHCl3) 0.32; infrared spectra (thin film method, cm^-1) 3411 (NH2 telescoping vibration), 3019 (aromatic CH telescoping vibration); elemental analyses (measured values: C, 28.89; H, 1.71; N, 24.99; C4H3N3Cl2-0.125); H2O theoretical values: C, 28.89; H, 1.71; N, 24.99; C4H3N3Cl2-0.125). H2O theoretical values: C, 28.90; H, 1.97; N, 25.28%); 1H NMR (500 MHz, CDCl3) δ 4.96 (2H, broad single peak, NH2), 7.90 (1H, single peak, 6-H); 13C NMR (125 MHz, CDCl3) δ 131.4, 134.6, 140.0, 150.3; Gas chromatography-mass spectrometry (GC-MS) m/z 167, 165, 163 (M+), retention time 2.51 min; purity 98%; high-resolution mass spectrometry (HRMS) measured value: MH+ m/z 163.9782, calculated value 163.9777.
References
[1] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 4, p. 354 - 358
[2] Tetrahedron, 2012, vol. 68, # 47, p. 9713 - 9728,16
[3] Tetrahedron, 2012, vol. 68, # 47, p. 9713 - 9728
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View Lastest Price from 2-AMINO-3,5-DICHLOROPYRAZINE manufacturers
- Product
- 3,5-dichloropyrazin-2-amine 873-42-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.9%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 2-AMINO-3,5-DICHLOROPYRAZINE 873-42-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 2-AMINO-3,5-DICHLOROPYRAZINE 873-42-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09