ChemicalBook > CAS DataBase List > 2-AMINO-3,5-DICHLOROPYRAZINE

2-AMINO-3,5-DICHLOROPYRAZINE

Product Name: 2-AMINO-3,5-DICHLOROPYRAZINE
CAS No.: 873-42-7
Chemical Name: 2-AMINO-3,5-DICHLOROPYRAZINE
Synonyms: 3,5-dichloropyrazin-2-aMine;3,5-Dichloro-pyrazin-2-ylamine;3,5-Dichloro-2-PyrazinaMine;2-AMini-3,5-dichloropyrazine;2-PyrazinaMine,3,5-dichloro-;3,5-Dichloro-2-aminopyrazine;2-Dmino-3,5-dichloropyrazine;2-AMINO-3,5-DICHLOROPYRAZINE;2-AMino-3,5-dichloropyrazine, 95+%;2-AMINO-3,5-DICHLOROPYRAZINE ISO 9001：2015 REACH
CBNumber: CB82455219
Molecular Formula: C4H3Cl2N3
Formula Weight: 163.99
MOL File: 873-42-7.mol

Less

2-AMINO-3,5-DICHLOROPYRAZINE Property

Melting point:: 140-142 °C
Boiling point:: 275.6±35.0 °C(Predicted)
Density: 1.606±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 0.89±0.10(Predicted)
Appearance: Light brown to yellow Solid

Less

Safety

HS Code: 2933199090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: D436135
Product name: 3,5-Dichloro-2-pyrazinamine
Packaging: 1g
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA72035
Product name: 2-Amino-3,5-dichloropyrazine
Packaging: 10g
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: J91190
Product name: 2-Amino-3,5-dichloropyrazine
Packaging: 25g
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA72035
Product name: 2-Amino-3,5-dichloropyrazine
Packaging: 2g
Price: $50
Updated: 2021/12/16

Matrix Scientific

Product number: 072542
Product name: 2-Amino-3,5-dichloropyrazine
Purity: 95+%
Packaging: 5g
Price: $58
Updated: 2021/12/16

Less

2-AMINO-3,5-DICHLOROPYRAZINE Chemical Properties,Usage,Production

Uses

3,5-Dichloro-2-pyrazinamine is used in the synthesis of pyrazinones as inhibitors of protein kinases, which play a key role in the progression of cancer. It is also used in the synthesis of N-substituted pyrazines by tandem reaction ofo-aminohalopyrazines with isothiocyanates.

Synthesis

6863-73-6

873-42-7

General procedure for the synthesis of 3,5-dichloropyrazin-2-amine from 2-amino-3-chloropyrazine: 2-amino-3-chloropyrazine (10.0 g, 77.2 mmol) was added to a stirred suspension of N-chlorosuccinimide (NCS, 11.6 g, 86.9 mmol) in chloroform (73 mL). The reaction mixture was heated to reflux for 4 hours. Upon completion of the reaction, the solution was cooled to room temperature and partitioned between chloroform (180 mL) and water (2 x 50 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using chloroform as eluent to afford 3,5-dichloropyrazin-2-amine (9.66 g, 76% yield) as a light yellow solid. The product characterization data were as follows: melting point 200-202°C; thin layer chromatography Rf value (CHCl3) 0.32; infrared spectra (thin film method, cm^-1) 3411 (NH2 telescoping vibration), 3019 (aromatic CH telescoping vibration); elemental analyses (measured values: C, 28.89; H, 1.71; N, 24.99; C4H3N3Cl2-0.125); H2O theoretical values: C, 28.89; H, 1.71; N, 24.99; C4H3N3Cl2-0.125). H2O theoretical values: C, 28.90; H, 1.97; N, 25.28%); 1H NMR (500 MHz, CDCl3) δ 4.96 (2H, broad single peak, NH2), 7.90 (1H, single peak, 6-H); 13C NMR (125 MHz, CDCl3) δ 131.4, 134.6, 140.0, 150.3; Gas chromatography-mass spectrometry (GC-MS) m/z 167, 165, 163 (M+), retention time 2.51 min; purity 98%; high-resolution mass spectrometry (HRMS) measured value: MH+ m/z 163.9782, calculated value 163.9777.

References

[1] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 4, p. 354 - 358
[2] Tetrahedron, 2012, vol. 68, # 47, p. 9713 - 9728,16
[3] Tetrahedron, 2012, vol. 68, # 47, p. 9713 - 9728

2-AMINO-3,5-DICHLOROPYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-AMINO-3,5-DICHLOROPYRAZINE Suppliers

China 141 Germany 1 India 1 United Kingdom 2 United States 10 Global 155

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Kohn & Shawn Pharmatech Co.,Ltd

Tel: 0931-4190454 13893344397
Fax: +86-931-8506154
Email: sales@kyxpharma.com
Country: China
ProdList: 310
Advantage: 55

Chiba Pharmaceutical Science and technology Co, Ltd.

Tel: 0531-81313138 13066006660
Fax: QQ: 3366077777
Email: chibapharm@foxmail.com
Country: China
ProdList: 3991
Advantage: 55

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

Suzhou Ryan Pharmachem Technology Co.,Ltd

Tel: 0512-66585217 13962137180
Fax: 0512-82177549
Email: sales@ryanchem.com
Country: China
ProdList: 384
Advantage: 55

Shanghai Hekang Biotechnology Co., Ltd.

Tel: 18939837085
Fax: 2880152141(QQ)
Email: youchemicals@gmail.com
Country: China
ProdList: 1839
Advantage: 55

Shanghai Leto Pharmatech Co.,Ltd.

Tel: 18016401466
Fax: QQ: 1375988926
Email: sales@letopharm.com
Country: China
ProdList: 245
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai YuYuan Pharmaceutical Co., Ltd.

Tel: 13052276172
Fax: 13052276172
Email: product@yuyuanpharm.com
Country: China
ProdList: 493
Advantage: 55

Nanjing Fast Bio-Pharmaceutical Co.,Ltd.

Tel: 025-58390181 58390186 18912901218
Fax: 025-58390182
Email: sales@fastchem.cn
Country: China
ProdList: 162
Advantage: 60

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Nanjing Duolong Bio-tech Co.,Ltd.

Tel: 18905173768
Fax: 025-83263139
Email: 52513593@qq.com
Country: China
ProdList: 2331
Advantage: 50

Shanghai Song Yuan Chemical Technology Co., Ltd.

Tel: 010-1234567 18521000990
Fax: 86-021-33275113
Email: sonyuanchemical@163.com
Country: China
ProdList: 6479
Advantage: 50

Shanghai XinKai Chemical Technology Co., Ltd.

Tel: 021-58930698 15921516558
Fax: 86-021-58933679
Email: zhangyichao84@126.com
Country: China
ProdList: 981
Advantage: 55

Suzhou Xinkai Bio-Medical Technology Co., Ltd.

Tel: 0512-67213637 13952409868
Email: peter19zhang@163.com
Country: China
ProdList: 442
Advantage: 55

Chengdu Research Accelerators Technology Co., Ltd.

Tel: 028-64353063
Fax: 028-64353063 QQ:784253935
Email: reacchemical@163.com
Country: China
ProdList: 5253
Advantage: 58

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

Shangdong Youbang Biochemical Technology Co.,LTD.

Tel: 15098208899
Fax: 0530-7159266
Email: 3368029756@qq.com
Country: China
ProdList: 292
Advantage: 58

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 028-88469284 18000562381
Email: rzbtsj@163.com
Country: China
ProdList: 9951
Advantage: 56

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 3495
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 0519-85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20794
Advantage: 60

WG reagent

Tel: 13391486464
Fax: QQ:14748090
Email: samwjf@163.com
Country: China
ProdList: 3086
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Cck Pharmchem Co.,Ltd

Tel: 0512-68131995 13862051930
Fax: 0512-68131995
Country: China
ProdList: 360
Advantage: 55

Chengdu Synguider Technology Co., Ltd.

Tel: 400-086-3412 028-85062459
Fax: 028-85062459
Email: synguider@163.com
Country: China
ProdList: 3295
Advantage: 55

Shanghai CR Corporation Limited

Tel: 13062833949; 4006653949 4006653949
Fax: QQ: 2136646215
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 9756
Advantage: 58

Wuxi KaideRui Pharmaceutical Technology Co., Ltd

Tel: 19906241957
Fax: -
Email: 1557216087@qq.com
Country: China
ProdList: 1837
Advantage: 55

Nanijing m&m biotechnology Co. ,Ltd.

Tel: 025-87782433 18021532344
Fax: 025-87782433
Email: 1345332203@qq.com
Country: China
ProdList: 4134
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Sichuan BaiPeng Biotechnology Co., Ltd.

Tel: 028-65791793 18140026355
Fax: QQ568470422
Email: 568470422@qq.com
Country: China
ProdList: 9997
Advantage: 58

Less

View Lastest Price from 2-AMINO-3,5-DICHLOROPYRAZINE manufacturers

Honest Joy Holdings Limited

Product: 3,5-dichloropyrazin-2-amine 873-42-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.9%
Supply Ability: 100 tons
Release date: 2022-02-18

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-AMINO-3,5-DICHLOROPYRAZINE 873-42-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-AMINO-3,5-DICHLOROPYRAZINE 873-42-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

873-42-7, 2-AMINO-3,5-DICHLOROPYRAZINERelated Search:

2,6-Dichloropyrazine 2-AMINO-3,5-DICHLOROPYRAZINE 3,5,6-TRICHLORO-N-METHYLPYRAZIN-2-AMINE

3,5-dichloropyrazin-2-aMine

3,5-Dichloro-2-PyrazinaMine

2-PyrazinaMine,3,5-dichloro-

2-AMini-3,5-dichloropyrazine

2-AMino-3,5-dichloropyrazine, 95+%

2-AMINO-3,5-DICHLOROPYRAZINE

3,5-Dichloro-pyrazin-2-ylamine

2-Dmino-3,5-dichloropyrazine

3,5-Dichloro-2-aminopyrazine

2-AMINO-3,5-DICHLOROPYRAZINE ISO 9001：2015 REACH

873-42-7