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2-AMINO-3,5-DICHLOROPYRAZINE

Product Name
2-AMINO-3,5-DICHLOROPYRAZINE
CAS No.
873-42-7
Chemical Name
2-AMINO-3,5-DICHLOROPYRAZINE
Synonyms
3,5-dichloropyrazin-2-aMine;3,5-Dichloro-pyrazin-2-ylamine;3,5-Dichloro-2-PyrazinaMine;2-AMini-3,5-dichloropyrazine;2-PyrazinaMine,3,5-dichloro-;3,5-Dichloro-2-aminopyrazine;2-Dmino-3,5-dichloropyrazine;2-AMINO-3,5-DICHLOROPYRAZINE;2-AMino-3,5-dichloropyrazine, 95+%;2-AMINO-3,5-DICHLOROPYRAZINE ISO 9001：2015 REACH
CBNumber
CB82455219
Molecular Formula
C4H3Cl2N3
Formula Weight
163.99
MOL File
873-42-7.mol
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2-AMINO-3,5-DICHLOROPYRAZINE Property

Melting point:
140-142 °C
Boiling point:
275.6±35.0 °C(Predicted)
Density 
1.606±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
0.89±0.10(Predicted)
Appearance
Light brown to yellow Solid
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Safety

HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D436135
Product name
3,5-Dichloro-2-pyrazinamine
Packaging
1g
Price
$120
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA72035
Product name
2-Amino-3,5-dichloropyrazine
Packaging
10g
Price
$120
Updated
2021/12/16
AK Scientific
Product number
J91190
Product name
2-Amino-3,5-dichloropyrazine
Packaging
25g
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA72035
Product name
2-Amino-3,5-dichloropyrazine
Packaging
2g
Price
$50
Updated
2021/12/16
Matrix Scientific
Product number
072542
Product name
2-Amino-3,5-dichloropyrazine
Purity
95+%
Packaging
5g
Price
$58
Updated
2021/12/16
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2-AMINO-3,5-DICHLOROPYRAZINE Chemical Properties,Usage,Production

Uses

3,5-Dichloro-2-pyrazinamine is used in the synthesis of pyrazinones as inhibitors of protein kinases, which play a key role in the progression of cancer. It is also used in the synthesis of N-substituted pyrazines by tandem reaction ofo-aminohalopyrazines with isothiocyanates.

Synthesis

6863-73-6

873-42-7

General procedure for the synthesis of 3,5-dichloropyrazin-2-amine from 2-amino-3-chloropyrazine: 2-amino-3-chloropyrazine (10.0 g, 77.2 mmol) was added to a stirred suspension of N-chlorosuccinimide (NCS, 11.6 g, 86.9 mmol) in chloroform (73 mL). The reaction mixture was heated to reflux for 4 hours. Upon completion of the reaction, the solution was cooled to room temperature and partitioned between chloroform (180 mL) and water (2 x 50 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using chloroform as eluent to afford 3,5-dichloropyrazin-2-amine (9.66 g, 76% yield) as a light yellow solid. The product characterization data were as follows: melting point 200-202°C; thin layer chromatography Rf value (CHCl3) 0.32; infrared spectra (thin film method, cm^-1) 3411 (NH2 telescoping vibration), 3019 (aromatic CH telescoping vibration); elemental analyses (measured values: C, 28.89; H, 1.71; N, 24.99; C4H3N3Cl2-0.125); H2O theoretical values: C, 28.89; H, 1.71; N, 24.99; C4H3N3Cl2-0.125). H2O theoretical values: C, 28.90; H, 1.97; N, 25.28%); 1H NMR (500 MHz, CDCl3) δ 4.96 (2H, broad single peak, NH2), 7.90 (1H, single peak, 6-H); 13C NMR (125 MHz, CDCl3) δ 131.4, 134.6, 140.0, 150.3; Gas chromatography-mass spectrometry (GC-MS) m/z 167, 165, 163 (M+), retention time 2.51 min; purity 98%; high-resolution mass spectrometry (HRMS) measured value: MH+ m/z 163.9782, calculated value 163.9777.

References

[1] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 4, p. 354 - 358
[2] Tetrahedron, 2012, vol. 68, # 47, p. 9713 - 9728,16
[3] Tetrahedron, 2012, vol. 68, # 47, p. 9713 - 9728

2-AMINO-3,5-DICHLOROPYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-3,5-DICHLOROPYRAZINE Suppliers

China 141 Germany 1 India 1 United Kingdom 2 United States 10 Global 155
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
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View Lastest Price from 2-AMINO-3,5-DICHLOROPYRAZINE manufacturers

Honest Joy Holdings Limited
Product
3,5-dichloropyrazin-2-amine 873-42-7
Price
US $0.00/KG
Min. Order
1KG
Purity
98.9%
Supply Ability
100 tons
Release date
2022-02-18
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-AMINO-3,5-DICHLOROPYRAZINE 873-42-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-AMINO-3,5-DICHLOROPYRAZINE 873-42-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

873-42-7, 2-AMINO-3,5-DICHLOROPYRAZINERelated Search:

2,6-Dichloropyrazine 2-AMINO-3,5-DICHLOROPYRAZINE 3,5,6-TRICHLORO-N-METHYLPYRAZIN-2-AMINE

  • 3,5-dichloropyrazin-2-aMine
  • 3,5-Dichloro-2-PyrazinaMine
  • 2-PyrazinaMine,3,5-dichloro-
  • 2-AMini-3,5-dichloropyrazine
  • 2-AMino-3,5-dichloropyrazine, 95+%
  • 2-AMINO-3,5-DICHLOROPYRAZINE
  • 3,5-Dichloro-pyrazin-2-ylamine
  • 2-Dmino-3,5-dichloropyrazine
  • 3,5-Dichloro-2-aminopyrazine
  • 2-AMINO-3,5-DICHLOROPYRAZINE ISO 9001：2015 REACH
  • 873-42-7