2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
- Product Name
- 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
- CAS No.
- 277299-70-4
- Chemical Name
- 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
- Synonyms
- 2-(3,4-dimethylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one;EltroMbopag II;ELTROMBOPAG INT;Eltrombopag Impurity 35;Eltrombopag Intermediate 1;Eltrombopag olamine Intermediate 4;1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone;1-(3,4-diMethylphenyl)-3-Methyl-1H-pyrazol-5-ol;2-(3,4-dimethylphenyl)-5-methyl-1H-pyrazol-3-one;2-Oxo-2,4,5,6,7,7a-Hexahydrothieno [3,2-c] Pyridine
- CBNumber
- CB82490074
- Molecular Formula
- C12H14N2O
- Formula Weight
- 202.25
- MOL File
- 277299-70-4.mol
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Property
- Melting point:
- 121.0 to 125.0 °C
- Boiling point:
- 338.5±52.0 °C(Predicted)
- Density
- 1.121
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 0.79±0.40(Predicted)
- color
- Pale Beige to Light Beige
- InChI
- InChI=1S/C12H14N2O/c1-8-4-5-11(6-9(8)2)14-12(15)7-10(3)13-14/h4-7,13H,1-3H3
- InChIKey
- HBWBJCSXUJIDGN-UHFFFAOYSA-N
- SMILES
- N1C(C)=CC(=O)N1C1=CC=C(C)C(C)=C1
Safety
- HS Code
- 2933.19.9000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D5064
- Product name
- 1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $52
- Updated
- 2025/07/31
- Product number
- D5064
- Product name
- 1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $261
- Updated
- 2025/07/31
- Product number
- D476930
- Product name
- 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
- Packaging
- 10g
- Price
- $580
- Updated
- 2021/12/16
- Product number
- J96725
- Product name
- 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
- Packaging
- 1g
- Price
- $34
- Updated
- 2021/12/16
- Product number
- 43262
- Product name
- 1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone,≥97%(GC)
- Purity
- ≥97%(GC)
- Packaging
- 1G
- Price
- $35.88
- Updated
- 2021/12/16
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Chemical Properties,Usage,Production
Uses
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one, is an impurity of Eltrombopag (E508000), which is agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.
Synthesis
141-97-9
60481-51-8
277299-70-4
1. In 250 mL of glacial acetic acid, 3,4-dimethylphenylhydrazine hydrochloride (17.7 g, 0.1 mol), ethyl acetoacetate (13.0 g, 0.1 mol), and sodium acetate (8.2 g, 0.1 mol) were added, and mixed with stirring. 2. The reaction mixture was heated to reflux for 24 hours. 3. After completion of the reaction, the mixture was cooled and the solvent was removed by evaporation. 4. The residue was dissolved in 1 L of ether and washed carefully with saturated aqueous sodium bicarbonate (5 x 200 mL). 5. The ether layer was separated and the ether was removed by evaporation to afford the target product 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-1H-pyrazol-3-one (15.4 g, 76% yield). 6. The product was subjected to 1H NMR. 6. The product was confirmed by 1H NMR (300 MHz, d6-DMSO) and mass spectrometry (ES) with the following characterization data: 1H NMR δ 11.30 (br s, 1H), 7.49 (d, J = 1.4 Hz, 1H), 7.43 (dd, J = 8.2 Hz, 1H), 7.14 (d, J = 8.2 Hz, 1H), 5.31 (s, 1H ), 2.20 (s, 3H), 2.22 (s, 3H), 2.08 (s, 3H); MS (ES) m/z 203 [M + H].
References
[1] Patent: US2004/53299, 2004, A1
[2] Patent: US2004/19190, 2004, A1. Location in patent: Page 17
[3] Patent: WO2016/35018, 2016, A1. Location in patent: Page/Page column 13
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Preparation Products And Raw materials
Raw materials
Preparation Products
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
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- Advantage
- 75
View Lastest Price from 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one manufacturers
- Product
- 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 277299-70-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-25
- Product
- 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 277299-70-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 277299-70-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2024-03-29