2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

Product Name: 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
CAS No.: 277299-70-4
Chemical Name: 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
Synonyms: 2-(3,4-dimethylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one;EltroMbopag II;ELTROMBOPAG INT;Eltrombopag Impurity 35;Eltrombopag Intermediate 1;Eltrombopag olamine Intermediate 4;1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone;1-(3,4-diMethylphenyl)-3-Methyl-1H-pyrazol-5-ol;2-(3,4-dimethylphenyl)-5-methyl-1H-pyrazol-3-one;2-Oxo-2,4,5,6,7,7a-Hexahydrothieno [3,2-c] Pyridine
CBNumber: CB82490074
Molecular Formula: C12H14N2O
Formula Weight: 202.25
MOL File: 277299-70-4.mol

More

Less

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Property

Melting point:: 121.0 to 125.0 °C
Boiling point:: 338.5±52.0 °C(Predicted)
Density: 1.121
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 0.79±0.40(Predicted)
color: Pale Beige to Light Beige
InChI: InChI=1S/C12H14N2O/c1-8-4-5-11(6-9(8)2)14-12(15)7-10(3)13-14/h4-7,13H,1-3H3
InChIKey: HBWBJCSXUJIDGN-UHFFFAOYSA-N
SMILES: N1C(C)=CC(=O)N1C1=CC=C(C)C(C)=C1

More

Less

Safety

HS Code: 2933.19.9000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: D5064
Product name: 1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $52
Updated: 2025/07/31

TCI Chemical

Product number: D5064
Product name: 1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $261
Updated: 2025/07/31

TRC

Product number: D476930
Product name: 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
Packaging: 10g
Price: $580
Updated: 2021/12/16

AK Scientific

Product number: J96725
Product name: 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
Packaging: 1g
Price: $34
Updated: 2021/12/16

Chem-Impex

Product number: 43262
Product name: 1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone,≥97%(GC)
Purity: ≥97%(GC)
Packaging: 1G
Price: $35.88
Updated: 2021/12/16

More

Less

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Chemical Properties,Usage,Production

Uses

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one, is an impurity of Eltrombopag (E508000), which is agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.

Synthesis

141-97-9

60481-51-8

277299-70-4

1. In 250 mL of glacial acetic acid, 3,4-dimethylphenylhydrazine hydrochloride (17.7 g, 0.1 mol), ethyl acetoacetate (13.0 g, 0.1 mol), and sodium acetate (8.2 g, 0.1 mol) were added, and mixed with stirring. 2. The reaction mixture was heated to reflux for 24 hours. 3. After completion of the reaction, the mixture was cooled and the solvent was removed by evaporation. 4. The residue was dissolved in 1 L of ether and washed carefully with saturated aqueous sodium bicarbonate (5 x 200 mL). 5. The ether layer was separated and the ether was removed by evaporation to afford the target product 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-1H-pyrazol-3-one (15.4 g, 76% yield). 6. The product was subjected to 1H NMR. 6. The product was confirmed by 1H NMR (300 MHz, d6-DMSO) and mass spectrometry (ES) with the following characterization data: 1H NMR δ 11.30 (br s, 1H), 7.49 (d, J = 1.4 Hz, 1H), 7.43 (dd, J = 8.2 Hz, 1H), 7.14 (d, J = 8.2 Hz, 1H), 5.31 (s, 1H ), 2.20 (s, 3H), 2.22 (s, 3H), 2.08 (s, 3H); MS (ES) m/z 203 [M + H].

References

[1] Patent: US2004/53299, 2004, A1
[2] Patent: US2004/19190, 2004, A1. Location in patent: Page 17
[3] Patent: WO2016/35018, 2016, A1. Location in patent: Page/Page column 13

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Suppliers

Americas 1 China 195 Europe 1 India 30 Japan 1 United States 8 Global 236

GLR Innovations

Tel: +91 9891111994
Email: info@glrgroup.in
Country: India
ProdList: 4535
Advantage: 58

TCI Chemicals (India) Pvt. Ltd.

Tel: --
Fax: --
Email: sales-in@tcichemicals.com
Country: India
ProdList: 6768
Advantage: 58

Aventus Labs

Tel: --
Fax: --
Email: info@aventuslabs.in
Country: India
ProdList: 42
Advantage: 58

Crams Technologies

Tel: --
Fax: --
Email: info@cramsindia.com
Country: India
ProdList: 11
Advantage: 58

Optimus Pharma (P) Ltd.

Tel: --
Fax: --
Email: kalpraj.g@optimuspharma.com
Country: India
ProdList: 33
Advantage: 58

SKVen Technologies Pvt.Ltd.

Tel: --
Fax: --
Email: kumar@skven.com
Country: India
ProdList: 17
Advantage: 58

SynZeal Research Pvt Ltd

Tel: --
Fax: --
Email: standards@synzeal.com
Country: India
ProdList: 6514
Advantage: 58

Ami Organics Limited.

Tel: --
Fax: --
Email: mail@amiorganics.com
Country: India
ProdList: 119
Advantage: 58

Styrax Pharma Private Ltd.

Tel: --
Fax: --
Email: ravi.dandu@styraxpharma.com
Country: India
ProdList: 15
Advantage: 58

Aravali Pharma & Lifesciences

Tel: --
Fax: --
Email: mail@aravalipharma.com
Country: India
ProdList: 71
Advantage: 58

Pharma Affiliates

Tel: --
Fax: --
Email: @pharmaffiliates.com
Country: India
ProdList: 6754
Advantage: 58

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

Syngenesis Chemscience Private Limited

Tel: --
Fax: --
Country: India
ProdList: 65
Advantage: 58

Pharmaffiliates Analytics and Synthetics P. Ltd

Tel: --
Fax: --
Email: mktg@pharmaffiliates.com
Country: India
ProdList: 6739
Advantage: 58

More

Less

View Lastest Price from 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 277299-70-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-25

Henan Aochuang Chemical Co.,Ltd.

Product: 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 277299-70-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 277299-70-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-03-29

277299-70-4, 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-oneRelated Search:

Eltrombopag

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

Eltrombopag Impurity 35

2-(3,4-Dimethylphenyl)-5-methyl-1H-pyrazol-3(2H)-one

2-(3,4-dimethylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one

Eltrombopag Intermediate 1

EltroMbopag II

2-Oxo-2,4,5,6,7,7a-Hexahydrothieno [3,2-c] Pyridine

1-(3,4-diMethylphenyl)-3-Methyl-1H-pyrazol-5-ol

1H-pyrazol-3(2H)-one,2-(3,4-Dimethylphenyl)-5-methyl-

2-(3,4-Dimethyl-phenyl)-5-methyl-1,2-dihydro-pyrazol-3-one

1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone

2-(3,4-dimethylphenyl)-5-methyl-1H-pyrazol-3-one

Eltrombopag olamine Intermediate 4

3H-Pyrazol-3-one, 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one ISO 9001：2015 REACH

ELTROMBOPAG INT

TIANFU CHEM 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-1H-pyrazol-3-one

2-(3,4-dimethylphenyl)-5-methyl-1,2- dihydroxypyrazol-3-one

2-(3,4-Dimethyl phenpyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

277299-70-4

77299-70-4