ChemicalBook > CAS DataBase List > 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

Product Name
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
CAS No.
277299-70-4
Chemical Name
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
Synonyms
2-(3,4-dimethylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one;EltroMbopag II;ELTROMBOPAG INT;Eltrombopag Impurity 35;Eltrombopag Intermediate 1;Eltrombopag olamine Intermediate 4;1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone;1-(3,4-diMethylphenyl)-3-Methyl-1H-pyrazol-5-ol;2-(3,4-dimethylphenyl)-5-methyl-1H-pyrazol-3-one;2-Oxo-2,4,5,6,7,7a-Hexahydrothieno [3,2-c] Pyridine
CBNumber
CB82490074
Molecular Formula
C12H14N2O
Formula Weight
202.25
MOL File
277299-70-4.mol
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2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Property

Melting point:
121.0 to 125.0 °C
Boiling point:
338.5±52.0 °C(Predicted)
Density 
1.121
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
0.79±0.40(Predicted)
color 
Pale Beige to Light Beige
InChI
InChI=1S/C12H14N2O/c1-8-4-5-11(6-9(8)2)14-12(15)7-10(3)13-14/h4-7,13H,1-3H3
InChIKey
HBWBJCSXUJIDGN-UHFFFAOYSA-N
SMILES
N1C(C)=CC(=O)N1C1=CC=C(C)C(C)=C1
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Safety

HS Code 
2933.19.9000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5064
Product name
1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$52
Updated
2025/07/31
TCI Chemical
Product number
D5064
Product name
1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$261
Updated
2025/07/31
TRC
Product number
D476930
Product name
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
Packaging
10g
Price
$580
Updated
2021/12/16
AK Scientific
Product number
Y6618
Product name
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
Packaging
5g
Price
$156
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
APN0000595
Product name
2-(3,4-DIMETHYL-PHENYL)-5-METHYL-1,2-DIHYDRO-PYRAZOL-3-ONE
Purity
95.00%
Packaging
1G
Price
$975.45
Updated
2021/12/16
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2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Chemical Properties,Usage,Production

Uses

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one, is an impurity of Eltrombopag (E508000), which is agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.

Synthesis

141-97-9

60481-51-8

277299-70-4

1. In 250 mL of glacial acetic acid, 3,4-dimethylphenylhydrazine hydrochloride (17.7 g, 0.1 mol), ethyl acetoacetate (13.0 g, 0.1 mol), and sodium acetate (8.2 g, 0.1 mol) were added, and mixed with stirring. 2. The reaction mixture was heated to reflux for 24 hours. 3. After completion of the reaction, the mixture was cooled and the solvent was removed by evaporation. 4. The residue was dissolved in 1 L of ether and washed carefully with saturated aqueous sodium bicarbonate (5 x 200 mL). 5. The ether layer was separated and the ether was removed by evaporation to afford the target product 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-1H-pyrazol-3-one (15.4 g, 76% yield). 6. The product was subjected to 1H NMR. 6. The product was confirmed by 1H NMR (300 MHz, d6-DMSO) and mass spectrometry (ES) with the following characterization data: 1H NMR δ 11.30 (br s, 1H), 7.49 (d, J = 1.4 Hz, 1H), 7.43 (dd, J = 8.2 Hz, 1H), 7.14 (d, J = 8.2 Hz, 1H), 5.31 (s, 1H ), 2.20 (s, 3H), 2.22 (s, 3H), 2.08 (s, 3H); MS (ES) m/z 203 [M + H].

References

[1] Patent: US2004/53299, 2004, A1
[2] Patent: US2004/19190, 2004, A1. Location in patent: Page 17
[3] Patent: WO2016/35018, 2016, A1. Location in patent: Page/Page column 13

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Suppliers

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View Lastest Price from 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 277299-70-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-25
Henan Aochuang Chemical Co.,Ltd.
Product
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 277299-70-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 277299-70-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-03-29

277299-70-4, 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-oneRelated Search:

Eltrombopag

  • 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
  • Eltrombopag Impurity 35
  • 2-(3,4-Dimethylphenyl)-5-methyl-1H-pyrazol-3(2H)-one
  • 2-(3,4-dimethylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one
  • Eltrombopag Intermediate 1
  • EltroMbopag II
  • 2-Oxo-2,4,5,6,7,7a-Hexahydrothieno [3,2-c] Pyridine
  • 1-(3,4-diMethylphenyl)-3-Methyl-1H-pyrazol-5-ol
  • 1H-pyrazol-3(2H)-one,2-(3,4-Dimethylphenyl)-5-methyl-
  • 2-(3,4-Dimethyl-phenyl)-5-methyl-1,2-dihydro-pyrazol-3-one
  • 1-(3,4-Dimethylphenyl)-3-methyl-5-pyrazolone
  • 2-(3,4-dimethylphenyl)-5-methyl-1H-pyrazol-3-one
  • Eltrombopag olamine Intermediate 4
  • 3H-Pyrazol-3-one, 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-
  • 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one ISO 9001：2015 REACH
  • ELTROMBOPAG INT
  • TIANFU CHEM 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
  • 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-1H-pyrazol-3-one
  • 2-(3,4-dimethylphenyl)-5-methyl-1,2- dihydroxypyrazol-3-one
  • 2-(3,4-Dimethyl phenpyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
  • 277299-70-4
  • 77299-70-4