ChemicalBook > CAS DataBase List > Eltrombopag Olamine

Eltrombopag Olamine

Product Name: Eltrombopag Olamine
CAS No.: 496775-62-3
Chemical Name: Eltrombopag Olamine
Synonyms: Eltrombopag olamine;Eltrombopag Diolamine;EltroMbopag OlaMine API;Revolade;Sb 497115gr;Unii-4U07F515;ELTROMBOPAG OL;Unii-4U07F515lg;Eltrombopag API;Promacta Olamine
CBNumber: CB82495099
Molecular Formula: C27H29N5O5
Formula Weight: 503.56
MOL File: 496775-62-3.mol

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Eltrombopag Olamine Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO:56.33(Max Conc. mg/mL);99.76(Max Conc. mM)
DMF:1.0(Max Conc. mg/mL);1.77(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.44(Max Conc. mM)
Ethanol:0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
form: Powder
color: Purple to black
Stability:: Hygroscopic
InChIKey: LQQUHOUXABUDJA-OUFJFOJPSA-N
SMILES: C(N)CO.O=C1/C(/C(C)=NN1C1C=CC(C)=C(C)C=1)=N\NC1C=CC=C(C2C=CC=C(C(=O)O)C=2)C=1O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: E508100
Product name: EltrombopagOlamine
Packaging: 5mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: 3608AH
Product name: Eltrombopagolamine
Packaging: 10mg
Price: $75
Updated: 2021/12/16

ApexBio Technology

Product number: A3387
Product name: EltrombopagOlamine
Packaging: 10mM(in 1mL DMSO)
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD157443
Product name: 3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid compd.with 2-aminoethanol
Packaging: 1g
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-1566
Product name: Eltrombopag(Olamine)
Purity: 99.96%
Packaging: 10mg
Price: $114
Updated: 2021/12/16

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Eltrombopag Olamine Chemical Properties,Usage,Production

Description

Eltrombopag Olamine is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. It has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C.

Uses

Treatment of chemotherapy-induced thrombocytopenia and treatment of immune thrombocytopenic purpura.

Clinical Use

Eltrombopag olamine, a thrombopoietin receptor (TpoR) agonist, was approved in late 2008 for the once-daily, oral short-term and long-term treatment of adult patients with previously treated chronic idiopathic thrombocytopenic purpura (ITP). It is the first small-molecule TpoR agonist and was launched in the U.S. for this indication in 2009 by GlaxoSmithKline (GSK). Because eltrombopag is a small molecule, the drug is administered orally and has a reduced potential for causing an immune system reaction versus alternative protein-based therapies. In 2010, eltrombopag was approved in Europe for the long-term treatment of adult patients with previously treated chronic ITP.

Synthesis

The synthesis began with the nitration of 2-bromophenol (39) with sodium nitrate and sulfuric acid in water at 10??C to give 2-bromo-6-nitrophenol (40) in 25% yield, which was methylated using methyl iodide and potassium carbonate in refluxing acetone providing 2-bromo- 6-nitroanisole (41) in 76% yield (the Scheme).40 Suzuki coupling of compound 41 with 3-carboxyphenyl boronic acid with Pd(PPh3)4 and 2 M sodium carbonate in refluxing dioxane gave 20-methoxy- 30-nitrobiphenyl-3-carboxylic acid (42) in 47% yield as a tan powder. Demethylation using 48% HBr (aq) in refluxing acetic acid resulted in a 79% yield of 20-hydroxy-30-nitrobiphenyl-3-carboxylic acid (43). The nitro group of compound 43 was reduced via catalytic hydrogenation at 50 psi at room temperature over Pd/C in mixed ethanol/3 M aq NaOH solution to give 30-amino-20-hydroxybiphenyl- 3-carboxylic acid (44) in quantitative yield. The intermediate 1-(3,4-dimethylphenyl)-3-methyl-2,5-dihydro-1Hpyrazol- 5-one (47) was prepared by condensing of 3,4-dimethylphenyl- hydrazine 45 with ethyl acetoacetate 46 with sodium acetate in refluxing acetic acid in 76% yield. Treatment of (44) with sodium nitrite in 1 M HCl at 5??C, followed by condensation with 1-(3,4-dimethylphenyl)-3-methyl-2,5-dihydro-1H-pyrazol-5-one (47) at a constant pH of 7¨C8 via the addition of sodium bicarbonate and ethanol afforded eltrombopag in 32% yield. Finally, eltrombopag was treated with hydroxyl ethylamine to give eltrombopag olamine (VIII).

in vivo

Eltrombopag Olamine (10 mg/kg; p.o. once a day for 5 days) shows good tolerance in chimpanzees^[1].
Eltrombopag Olamine (17.6 mg/kg; IP; once a day for 2 days) significantly reduces mean S. aureus counts in mice nasal infection^[3].

Animal Model:	Female chimpanzees^[1]
Dosage:	10 mg/kg
Administration:	Oral gavage; 10 mg/kg once a day; for 5 days
Result:	Appeared a goes up and then goes back tendency of platelet counts after treatment, and showed no bad effects of hematology, coagulation, or clinical chemistry parameters on animal.

Animal Model:	C57BL/6 male mice (7 weeks, 20-22 g; injected S. aureus (5 × 10⁸ CFU suspended in 40 μL PBS) into the nasal cavities)^[3]
Dosage:	17.6 mg/kg
Administration:	IP; once a day for 2 days
Result:	Significantly reduced mean bacterial counts (5.0 × 10⁶ CFU/lung) in the nasal infection model compared with control PBS (5.2 × 10⁷ CFU/lung) mice.

Eltrombopag Olamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Eltrombopag Olamine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Eltrombopag olamine 496775-62-3
Price: US $0.00/g
Min. Order: 1g
Purity: 98.0%min
Supply Ability: 10KGS
Release date: 2021-06-23

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Eltrombopag olamine 496775-62-3
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 50kg/Month
Release date: 2024-07-23

Dingwang Technology (Wuhan) Co., Ltd.

Product: Eltrombopag Olamine 496775-62-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 TONS
Release date: 2022-11-07

496775-62-3, Eltrombopag OlamineRelated Search:

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Eltrombopag olamine

Sb 497115gr

Unii-4U07F515lg

3'-[(2Z)-2-[1-(3,4-DiMethylphenyl)-1,5-dihydro-3-Methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid coMpd. with 2-aMinoethanol(1:2)

EltroMbopag diethanolaMine salt

EltroMbopag OlaMine API

EltroMbopag IMpurity

Eltrombopag Diolamine

2-aminoethanol with (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate (2:1)

Unii-4U07F515

2-aminoethanol,3-[(5E)-5-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]hydrazinylidene]-6-oxocyclohexa-1,3-dien-1-yl]benzoic acid

2-Aminoethanol (E)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydra

ELTROMBOPAG OLAMINE IH

ELTROMBOPAG OL

3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid compd. with 2-aminoethanol

Revolade

ELTROMBOPAG DIETHANOLAMINE SALT; PROMACTA; REVOLADE; SB-497115GR

2-aminoethanol (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate

Eltrombopag Olamin

Eltrombopag ethanolamine

Promacta Olamine

2-aminoethanolhemi((Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate)

2-aminoethanol,3-[(5E)-5-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]hydrazinylidene]-6-oxocyclohexa-1,3-dien-1-yl]benzoicaci

Unii-4U07F515lg ISO 9001：2015 REACH

ltrombopag Impurity 13

Eltrombopag Olamine (SB-497115GR)

Eltrombopag OlamineQ: What is Eltrombopag Olamine Q: What is the CAS Number of Eltrombopag Olamine Q: What are the applications of Eltrombopag Olamine

8-Benzothiazolecarboxaldehyde

2-Aminoethan-1-ol hemi((Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate)

Eltrombopag API

Altropopalthanolamine

Eltrombopag (SB497115) Olamine

Form I of Eltrombopag Olamine

Eltrombopag Olamine - API Standards

Eltrombopag Olamine, 10 mM in DMSO

Eltrombopag Ethanolamine Salt

(Z)-3'-[2-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxopyrazol-4(5H)-ylidene]hydrazino]-2'-hydroxybiphenyl-3-carboxylic Acid compd. with 2-Aminoethanol (1:2)

496775-62-3

C25H22N4O42C2H7NO

API

496775-62-3