Darunavir ethanolate
- Product Name
- Darunavir ethanolate
- CAS No.
- 635728-49-3
- Chemical Name
- Darunavir ethanolate
- Synonyms
- Darunavir ethanolate;Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3R,3as,6ar)-hexahydrofuro(2,3-B)furan-3-yl ester, compd. with ethanol (1:1);To the drug;Unii-33o78xf0bw;[14C]-Darunavir ethanolate;Darunavir Ethanolate (100 mg);Darunavir Ethanolate(Prezista);Darunavir Ethanolate (DRV, Prezista);DARUNAVIR ETHANOLATE (TMC114 ETHANOLATE);Darunavir(TMC-114,UIC 94017) Ethanolate
- CBNumber
- CB32496602
- Molecular Formula
- C29H43N3O8S
- Formula Weight
- 593.74
- MOL File
- 635728-49-3.mol
Darunavir ethanolate Property
- Melting point:
- 98-100°C
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White
Safety
- HS Code
- 29334900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D193520
- Product name
- DarunavirEthanolate
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 163597
- Product name
- Darunavir Ethanolate
- Packaging
- 5mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- D193520
- Product name
- DarunavirEthanolate
- Packaging
- 50mg
- Price
- $770
- Updated
- 2021/12/16
- Product number
- CS-0750
- Product name
- DarunavirEthanolate
- Purity
- 99.92%
- Packaging
- 100mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- FD64995
- Product name
- Darunavir Ethanolate
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
Darunavir ethanolate Chemical Properties,Usage,Production
Uses
Darunavir Ethanolate(Prezista) is an inhibitor of HIV protease. [1] Darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including strains from treatment-experienced patients with multiple resistance mutati
Uses
Darunavir Ethanolate (Prezista) is an HIV protease inhibitor. Derivative of Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.
Biological Activity
darunavir ethanolate is a nonpeptidic hiv protease inhibitor approved for the treatment of hiv infection[1].transepithelial transport of darunavir in caco-2 cell monolayers is 2-fold greater in the basal-to-apical direction compared to that in the opposite direction. in l-mdr1 cell, darunavir (121 mm) inhibits p-glycoprotein-mediated efflux of calcein-acetoxymethyl ester[1].darunavir is effective against wild-type and pi-resistant hiv, and has a low oral bioavailability (37%). when used in combination with ritonavir, bioavailability can be increased to 82%[2].[1]. fujimoto h, higuchi m, watanabe h, et al. p-glycoprotein mediates efflux transport of darunavir in human intestinal caco-2 and abcb1 gene-transfected renal llc-pk1 cell lines. biological & pharmaceutical bulletin, 2009, 32(9): 1588-1593.[2]. bhalekar mr, et al. in-vivo bioavailability and lymphatic uptake evaluation of lipid nanoparticulates of darunavir. drug deliv, 2016, 23(7): 2581-2586.
Darunavir ethanolate Preparation Products And Raw materials
Raw materials
Preparation Products
Darunavir ethanolate Suppliers
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View Lastest Price from Darunavir ethanolate manufacturers
- Product
- Darunavir ethanolate 635728-49-3
- Price
- US $0.00/Kg/Bag
- Min. Order
- 2Kg/Bag
- Purity
- 0.0099
- Supply Ability
- 20 tons
- Release date
- 2021-08-05
- Product
- Unii-33o78xf0bw 635728-49-3
- Price
- US $63.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2021-06-04
- Product
- Unii-33o78xf0bw 635728-49-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10