ChemicalBook > CAS DataBase List > Nsc66811

Nsc66811

Product Name
Nsc66811
CAS No.
6964-62-1
Chemical Name
Nsc66811
Synonyms
Nsc66811;NSC 66811; NSC66811; NSC-66811;7-(alpha-Anilinobenzyl)-2-methyl-8-quinolinol;7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol;2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol;2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol;8-Quinolinol,2-methyl-7-[phenyl(phenylamino)methyl]-;8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline
CBNumber
CB82498106
Molecular Formula
C23H20N2O
Formula Weight
340.42
MOL File
6964-62-1.mol
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Nsc66811 Property

Melting point:
143.0 to 147.0 °C
Boiling point:
529.5±45.0 °C(Predicted)
Density 
1.235±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in DMSO (up to 25 mg/ml).
form 
solid
pka
4.42±0.50(Predicted)
color 
White
λmax
250nm(EtOH)(lit.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Safety

HS Code 
2933.49.7000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
444144
Product name
MDM2 Antagonist II, NSC 66811
Purity
The MDM2 Antagonist II, NSC 66811, also referenced under CAS 6964-62-1, controls the biological activity of MDM2.
Packaging
10MG
Price
$219
Updated
2023/06/20
TCI Chemical
Product number
M2390
Product name
2-Methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol
Purity
>98.0%(GC)
Packaging
25mg
Price
$77
Updated
2024/03/01
TCI Chemical
Product number
M2390
Product name
2-Methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol
Purity
>98.0%(GC)
Packaging
100mg
Price
$191
Updated
2024/03/01
Cayman Chemical
Product number
16431
Product name
NSC 66811
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
16431
Product name
NSC 66811
Purity
≥95%
Packaging
5mg
Price
$108
Updated
2024/03/01
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Nsc66811 Chemical Properties,Usage,Production

Description

NSC 66811 (6964-62-1) is a novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. NSC-66811 binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.

Uses

NSC 66811 is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. NSC 66811 activates p53 in colon cancer cells.

References

1) Lu et al. (2006), Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy; J. Med. Chem., 49 3759

Nsc66811 Preparation Products And Raw materials

Raw materials

Preparation Products

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Nsc66811 Suppliers

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6964-62-1, Nsc66811Related Search:

17-AAG TYRPHOSTIN AG 1296 CL 82198 HYDROCHLORIDE AAL-993 (S)-(+)-Benzyl glycidyl ether N-Ethylaniline N-Methylaniline o-Toluidine N-Benzylideneaniline

  • Nsc66811
  • 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
  • 7-(alpha-Anilinobenzyl)-2-methyl-8-quinolinol
  • 2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol
  • 7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol
  • 8-Quinolinol,2-methyl-7-[phenyl(phenylamino)methyl]-
  • NSC 66811; NSC66811; NSC-66811
  • 8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline
  • 6964-62-1