ChemicalBook > CAS DataBase List > AZD-8055

AZD-8055

Product Name: AZD-8055
CAS No.: 1009298-09-2
Chemical Name: AZD-8055
Synonyms: CS-1935;CCG 168;AZD-8055;AZD8055, >=98%;AZD8055 ，S1555;AZD8055,AZD-8055;AZD-8055 USP/EP/BP;AZD-8055, 10 mM in DMSO;Dapagliflozin Impurity 167;AZD-8055; AZD8055; AZD 8055.
CBNumber: CB82501402
Molecular Formula: C25H31N5O4
Formula Weight: 465.54
MOL File: 1009298-09-2.mol

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AZD-8055 Property

Melting point:: 204 - 207°C
Boiling point:: 694.3±65.0 °C(Predicted)
Density: 1.248
storage temp.: -20°C
solubility: Soluble in DMSO (up to 30 mg/ml)
form: Yellow powder.
pka: 14.20±0.10(Predicted)
color: Yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

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Safety

Safety Statements: 24/25
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16978
Product name: AZD 8055
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16978
Product name: AZD 8055
Purity: ≥98%
Packaging: 5mg
Price: $87
Updated: 2024/03/01

Cayman Chemical

Product number: 16978
Product name: AZD 8055
Purity: ≥98%
Packaging: 10mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 16978
Product name: AZD 8055
Purity: ≥98%
Packaging: 50mg
Price: $384
Updated: 2024/03/01

Usbiological

Product number: 003022
Product name: AZD8055
Packaging: 10mg
Price: $425
Updated: 2021/12/16

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AZD-8055 Chemical Properties,Usage,Production

Description

AZD8055 (1009298-09-2) is a potent and highly selective inhibitor of mammalian target of rapamycin kinase (mTOR) kinase (IC50 = 0.8 nM).1,2 ?mTOR acts as a nutrient/energy/redox sensor and a controller of protein synthesis – as such it is a very important target for cancer research.? It has been investigated as a potential chemotherapeutic for various cancers.3-7

Uses

A novel ATP-competitive inhibitor of mTOR with an IC50 of 0.8 nM.

Uses

A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphoryla tion of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dep endent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S 6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition.

Definition

ChEBI: AZD-8055 is a pyridopyrimidine that is pyrido[2,3-d]pyrimidine which is substituted at positions 2 and 4 by (3S)-3-methylmorpholin-4-yl groups and at position 5 by a 3-(hydroxymethyl)-4-methoxyphenyl group. It is an mTOR complex 1/2 (mTORC1/2) dual inhibitor [mTOR = mammalian target of rapamycin]. It has a role as a mTOR inhibitor, an apoptosis inducer and an antineoplastic agent. It is a member of benzyl alcohols, a tertiary amino compound, a pyridopyrimidine and a member of morpholines.

target

mTOR (full length)

storage

Store at -20°C

References

[1] CHRISTINE M CHRESTA. AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.[J]. Cancer research, 2010, 70 1: 288-298. DOI:10.1158/0008-5472.can-09-1751
[2] KURT G. PIKE . Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23 5: Pages 1212-1216. DOI:10.1016/j.bmcl.2013.01.019
[3] SARAH V HOLT. Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055).[J]. Cancer research, 2012: 1804-1813. DOI:10.1158/0008-5472.can-11-1780
[4] L WILLEMS. The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia[J]. Leukemia, 2011, 26 6: 1195-1202. DOI:10.1038/leu.2011.339
[5] SHAORU LI. The mTOR inhibitor AZD8055 inhibits proliferation and glycolysis in cervical cancer cells.[J]. Oncology Letters, 2013: 717-721. DOI:10.3892/ol.2012.1058
[6] QIANG LI . The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro[J]. Biochemical and biophysical research communications, 2013, 440 4: Pages 701-706. DOI:10.1016/j.bbrc.2013.09.130
[7] MIN HU. AZD8055 induces cell death associated with autophagy and activation of AMPK in hepatocellular carcinoma.[J]. Oncology reports, 2014: 649-656. DOI:10.3892/or.2013.2890

AZD-8055 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-8055 Suppliers

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View Lastest Price from AZD-8055 manufacturers

Career Henan Chemical Co

Product: AZD-8055 1009298-09-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 495
Release date: 2019-09-01

Career Henan Chemical Co

Product: AZD-8055 1009298-09-2
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

1009298-09-2, AZD-8055Related Search:

AZD-0284 AZD-5305 AZD 3759 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- AZD3839 hemifuMarate KGZHRAVDXGQUQM-WCQGTBRESA-N (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine AZD-2858 AZD-0156 ZM 447439 CYCLOPAMINE AAL-993 17-AAG Everolimus Selumetinib MK-2206 2HCl Rapamycin Olaparib

CS-1935

{5-[2,4-Bis-(3-methyl-morpholin-4-yl)-pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-phenyl}-methanol

AZD-8055; AZD8055; AZD 8055.

AZD 8055 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol

AZD8055, >=98%

Propanoic acid, 2,2-dimethyl-, [5-(2,4-dichloropyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl]methyl ester

(5-{2,4-dichloropyrido[2,3-d]pyriMidin-7-yl}-2-Methoxyphenyl)Methyl 2,2-diMethylpropanoate

[5-[2,4-Bis((3S)-3-MethylMorpholin-4-yl)pyrido[

5-[2,4-Bis[(3S)-3-Methyl-4-Morpholinyl]pyrido[2,3-d]pyriMidin-7-yl]-2-MethoxybenzeneMethanol

CCG 168

AZD8055,AZD-8055

AZD-8055

[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol

(5-(2,4-Bis((S)-3-methylmorpholino)pyrido-[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol

[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol AZD 8055

Benzenemethanol, 5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-

AZD-8055 USP/EP/BP

(5-{2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl}-2-methoxyphenyl)methanol

AZD8055 MTOR inhibitor AZD-8055

inhibit,AZD-8055,AZD8055,Apoptosis,mTOR,Mammalian target of Rapamycin,AZD 8055,Inhibitor,Autophagy

Dapagliflozin Impurity 167

AZD-8055, 10 mM in DMSO

AZD8055 ，S1555

1009298-09-2

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Protein Kinase Inhibitors and Activators

Akt

mTOR

PI3K

Inhibitors

PI3K/Akt/mTOR