AZD-0284

Product Name: AZD-0284
CAS No.: 2101291-07-8
Chemical Name: AZD-0284
Synonyms: AZD-0284;AZD-0284, 10 mM in DMSO;(R)-2-Acetyl-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-5-(methylsulfonyl)isoindoline-1-carboxamide; (1R)-2-acetyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-methanesulfonyl-2,3-dihydro-1H-isoindole-1-carboxamide;1H-Isoindole-1-carboxamide, 2-acetyl-2,3-dihydro-5-(methylsulfonyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-, (1R)-;tract,RAR-related orphan receptor,IL-17F,L-23R,Inhibitor,AZD-0284,plaque,respiratory,vulgaris,production,IL-17A,TH17,psoriasis,IL-22,AZD 0284,inhibit,cells,ROR,AZD0284
CBNumber: CB74667590
Molecular Formula: C21H18F6N2O5S
Formula Weight: 524.43
MOL File: 2101291-07-8.mol

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AZD-0284 Property

Boiling point:: 731.9±60.0 °C(Predicted)
Density: 1.534±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (190.68 mM)
form: Solid
pka: 9.26±0.15(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0077736
Product name: AZD-0284
Purity: 99.92%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0077736
Product name: AZD-0284
Purity: 99.92%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0077736
Product name: AZD-0284
Purity: 99.92%
Packaging: 50mg
Price: $2250
Updated: 2021/12/16

ChemScene

Product number: CS-0077736
Product name: AZD-0284
Purity: 99.92%
Packaging: 100mg
Price: $3350
Updated: 2021/12/16

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AZD-0284 Chemical Properties,Usage,Production

Uses

AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ. AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment[1].

References

[1] Narjes, F, et al. The discovery of AZD0284, an inverse agonist of the nuclear receptor RORg. American Chemical Society, 2017 Drug Design and Delivery Symposium 26 October 2017
[2] Asimus S, et al. Pharmacokinetics, pharmacodynamics and safety of the inverse retinoic acid-related orphan receptor γ agonist AZD0284 [published online ahead of print, 2020 Feb 17]. Br J Clin Pharmacol. 2020;10.1111/bcp.14253. DOI:10.1111/bcp.14253

AZD-0284 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-0284 Suppliers

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2101291-07-8, AZD-0284Related Search:

AZD-5672 AZD0364 CCR1 antagonist AZD-7648 AZD5153 AZD-8055 AZD-5305 AZD 3759 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- AZD3839 hemifuMarate KGZHRAVDXGQUQM-WCQGTBRESA-N (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine AZD-2858 AZD-0156

AZD-0284

1H-Isoindole-1-carboxamide, 2-acetyl-2,3-dihydro-5-(methylsulfonyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-, (1R)-

(1R)-2-acetyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-methanesulfonyl-2,3-dihydro-1H-isoindole-1-carboxamide

tract,RAR-related orphan receptor,IL-17F,L-23R,Inhibitor,AZD-0284,plaque,respiratory,vulgaris,production,IL-17A,TH17,psoriasis,IL-22,AZD 0284,inhibit,cells,ROR,AZD0284

(R)-2-Acetyl-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-5-(methylsulfonyl)isoindoline-1-carboxamide

AZD-0284, 10 mM in DMSO

2101291-07-8

C21H18F6N2O5S