ChemicalBook > CAS DataBase List > AZD-7648

AZD-7648

Product Name
AZD-7648
CAS No.
2230820-11-6
Chemical Name
AZD-7648
Synonyms
AZD7640;CPD2810;AZD-7648;AZD-7648, 10 mM in DMSO;AZD-7648;AZD 7648;AZD7648;7-Methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one;7-Methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one;8H-Purin-8-one, 7,9-dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-;DNA-dependent protein kinase,inhibit,Apoptosis,AZD7648,A549,OAW42,PI3K,Inhibitor,Phosphoinositide 3-kinase,AZD-7648,Ataxia telangiectasia mutated,antitumor,ATM and RAD3 related,ATM/ATR,AZD 7648,DNA-PK
CBNumber
CB84844134
Molecular Formula
C18H20N8O2
Formula Weight
380.4
MOL File
2230820-11-6.mol
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AZD-7648 Property

Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 5 mg/mL (13.14 mM; ultrasonic and warming and heat to 80°C)
form 
A crystalline solid
pka
3.53±0.20(Predicted)
color 
Off-white to light yellow
InChI
InChI=1S/C18H20N8O2/c1-11-7-15-20-10-21-25(15)9-13(11)22-17-19-8-14-16(23-17)26(18(27)24(14)2)12-3-5-28-6-4-12/h7-10,12H,3-6H2,1-2H3,(H,19,22,23)
InChIKey
XISVSTPEXYIKJL-UHFFFAOYSA-N
SMILES
N1(C)C2C(=NC(NC3=CN4N=CN=C4C=C3C)=NC=2)N(C2CCOCC2)C1=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28598
Product name
AZD 7648
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
28598
Product name
AZD 7648
Packaging
25mg
Price
$704
Updated
2024/03/01
Cayman Chemical
Product number
28598
Product name
AZD 7648
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
28598
Product name
AZD 7648
Packaging
10mg
Price
$301
Updated
2024/03/01
ChemScene
Product number
CS-0091859
Product name
AZD-7648
Purity
99.89%
Packaging
5mg
Price
$100
Updated
2021/12/16
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AZD-7648 Chemical Properties,Usage,Production

Uses

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity in non small cell lung cancer.

in vivo

AZD-7648 (100 mg/kg; p.o.; once daily for 5 days) induces tumour growth inhibition and tumour regression[1].

Animal Model:Nude mice, A549 xenografts and NCI-H1299 xenografts[1]
Dosage:100 mg/kg
Administration:Oral administration, once daily for 5 days
Result:Induced tumour growth inhibition in combination with IR in A549 xenografts and induced tumour regression in combination with IR in NCI-H1299 xenografts.

IC 50

PI3Kγ: 1.37 μM (IC50); ATM: 17.93 μM (IC50); DNA-PKcs: 91.3 nM (IC50)

storage

Store at -20°C

AZD-7648 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-7648 Suppliers

China 100 United States 6 Global 106
Fujian boshi pharmaceutical technology co. LTD
Tel
0595-22008920; 18120708884
Email
393612455@qq.com
Country
China
ProdList
255
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Wuhan Luohua Medical Technology Co.,Ltd.
Tel
13477084141; 13477084141
Fax
+86(27)65566697
Email
sales@luohuapharm.com
Country
China
ProdList
468
Advantage
60
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Suzhou Sino Rare Chemical Co., Ltd.
Tel
0512-62857507
Fax
+86-512-62857507
Email
sales@sinorarechem.com
Country
China
ProdList
991
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
984
Advantage
55
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.
Tel
027-65388397 18164111589
Fax
027-65388397
Email
3321478047@qq.com
Country
China
ProdList
2007
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
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View Lastest Price from AZD-7648 manufacturers

Career Henan Chemical Co
Product
AZD-7648 2230820-11-6
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10
Career Henan Chemical Co
Product
AZD-7648 2230820-11-6
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10

2230820-11-6, AZD-7648Related Search:

AZD-5672 AZD0364 CCR1 antagonist AZD5153 AZD-8055 AZD-0284 AZD-5305 AZD 3759 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- AZD3839 hemifuMarate KGZHRAVDXGQUQM-WCQGTBRESA-N (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine AZD-2858 AZD-0156

  • CPD2810
  • AZD-7648
  • AZD-7648;AZD 7648;AZD7648
  • 7-Methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7H-purin-8(9H)-one
  • AZD7640
  • 8H-Purin-8-one, 7,9-dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-
  • 7-Methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one
  • DNA-dependent protein kinase,inhibit,Apoptosis,AZD7648,A549,OAW42,PI3K,Inhibitor,Phosphoinositide 3-kinase,AZD-7648,Ataxia telangiectasia mutated,antitumor,ATM and RAD3 related,ATM/ATR,AZD 7648,DNA-PK
  • AZD-7648, 10 mM in DMSO
  • 2230820-11-6
  • Csub1subsub8subHsub2subsub0subNsub8subOsub2sub
  • APIs
  • api