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AZD-5672

Product Name
AZD-5672
CAS No.
780750-65-4
Chemical Name
AZD-5672
Synonyms
AZD-5672;UNII-61XQN688TW;AZD-5672, 10 mM in DMSO;N-{1-[(3R)-3-(3,5-difluorophenyl)-3-(4-methanesulfonylphenyl)propyl]piperidin-4-yl}-N-ethyl-2-(4-methanesulfonylphenyl)acetamide;Benzeneacetamide, N-[1-[(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl]-4-piperidinyl]-N-ethyl-4-(methylsulfonyl)-
CBNumber
CB94919929
Molecular Formula
C32H38F2N2O5S2
Formula Weight
632.78
MOL File
780750-65-4.mol
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AZD-5672 Property

Boiling point:
800.4±65.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
form 
Solid
pka
8.54±0.20(Predicted)
color 
White to light brown
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Hazard and Precautionary Statements (GHS)

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AZD-5672 Chemical Properties,Usage,Production

Uses

AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC50=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC50=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis[1][2][3].

in vivo

In vivo pharmaeokineties data for AZD-5672 (compound 1)[1]

SpeciesCIa
(mL/min/kg)		Vssa (L/kg)t1/2a (h)Fb (%)
Rat285.32.638
Dog185.73.986

a AZD-5672 dosed 1-2 mg/kg i.v.
b AZD-5672 dosed 2-5 mg/kg p.o.

IC 50

CCR5: 0.32 nM (IC50); hERG: 7.3 μM (IC50); hP-gp: 32 μM (IC50)

References

[1] Cumming JG, et al. Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1655-9. DOI:10.1016/j.bmcl.2011.12.117
[2] Elsby R, et al. The utility of in vitro data in making accurate predictions of human P-glycoprotein-mediated drug-drug interactions: a case study for AZD5672. Drug Metab Dispos. 2011 Feb;39(2):275-82. DOI:10.1124/dmd.110.035881
[3] Gerlag DM, et al. Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate. Arthritis Rheum. 2010 Nov;62(11):3154-60. DOI:10.1002/art.27652

AZD-5672 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-5672 Suppliers

China 22 United States 4 Global 26
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
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United States
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12952
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65
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
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China
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3506
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58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
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4757
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55
ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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8000
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
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32435
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58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
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sales@chemhifuture.com
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China
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2998
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58
TargetMol Chemicals Inc.
Tel
4008200310
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marketing@tsbiochem.com
Country
China
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24961
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58
Shanghai Tachizaki Biomedical Research Center
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18014399201
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sales@chemlab-tachizaki.com
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China
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2742
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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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024-024-024-88590548 18341751992
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757984502@qq.com
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China
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942
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Wuhan Jingkangen Biomedical Technology Co., Ltd
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13720134139 086-15871494362 13720134139
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orders@jknbiochem.com
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China
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6614
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58

780750-65-4, AZD-5672Related Search:

AZD0364 CCR1 antagonist AZD-7648 AZD5153 AZD-8055 AZD-0284 AZD-5305 AZD 3759 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- AZD3839 hemifuMarate KGZHRAVDXGQUQM-WCQGTBRESA-N (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine AZD-2858 AZD-0156

  • AZD-5672
  • UNII-61XQN688TW
  • Benzeneacetamide, N-[1-[(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl]-4-piperidinyl]-N-ethyl-4-(methylsulfonyl)-
  • N-{1-[(3R)-3-(3,5-difluorophenyl)-3-(4-methanesulfonylphenyl)propyl]piperidin-4-yl}-N-ethyl-2-(4-methanesulfonylphenyl)acetamide
  • AZD-5672, 10 mM in DMSO
  • 780750-65-4