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AZD-5672

Product Name
AZD-5672
CAS No.
780750-65-4
Chemical Name
AZD-5672
Synonyms
AZD-5672;UNII-61XQN688TW;AZD-5672, 10 mM in DMSO;N-{1-[(3R)-3-(3,5-difluorophenyl)-3-(4-methanesulfonylphenyl)propyl]piperidin-4-yl}-N-ethyl-2-(4-methanesulfonylphenyl)acetamide;Benzeneacetamide, N-[1-[(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl]-4-piperidinyl]-N-ethyl-4-(methylsulfonyl)-
CBNumber
CB94919929
Molecular Formula
C32H38F2N2O5S2
Formula Weight
632.78
MOL File
780750-65-4.mol
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AZD-5672 Property

Boiling point:
800.4±65.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
form 
Solid
pka
8.54±0.20(Predicted)
color 
White to light brown
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Hazard and Precautionary Statements (GHS)

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AZD-5672 Chemical Properties,Usage,Production

Uses

AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC50=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC50=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis[1][2][3].

in vivo

In vivo pharmaeokineties data for AZD-5672 (compound 1)[1]

SpeciesCIa
(mL/min/kg)		Vssa (L/kg)t1/2a (h)Fb (%)
Rat285.32.638
Dog185.73.986

a AZD-5672 dosed 1-2 mg/kg i.v.
b AZD-5672 dosed 2-5 mg/kg p.o.

IC 50

CCR5: 0.32 nM (IC50); hERG: 7.3 μM (IC50); hP-gp: 32 μM (IC50)

References

[1] Cumming JG, et al. Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1655-9. DOI:10.1016/j.bmcl.2011.12.117
[2] Elsby R, et al. The utility of in vitro data in making accurate predictions of human P-glycoprotein-mediated drug-drug interactions: a case study for AZD5672. Drug Metab Dispos. 2011 Feb;39(2):275-82. DOI:10.1124/dmd.110.035881
[3] Gerlag DM, et al. Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate. Arthritis Rheum. 2010 Nov;62(11):3154-60. DOI:10.1002/art.27652

AZD-5672 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-5672 Suppliers

China 22 United States 4 Global 26
ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185
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sales-cpd@caerulumpharma.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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8000
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Nantong Hi-Future Biotechnology Co., Ltd
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18051384581
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sales@chemhifuture.com
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China
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2998
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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24961
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Shanghai Tachizaki Biomedical Research Center
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18014399201
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sales@chemlab-tachizaki.com
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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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024-024-024-88590548 18341751992
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757984502@qq.com
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Wuhan Jingkangen Biomedical Technology Co., Ltd
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13720134139 086-15871494362 13720134139
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orders@jknbiochem.com
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Nantong QuanYi Biotechnology Co., Ltd
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0513-66337626 18051384581
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sales@chemhifuture.com
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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customer_service@efebio.com
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https://hanhongsci.com/
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021-54306202 18917919676
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info@hanhongsci.com
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Shandong Mopai Biotechnology Co., Ltd
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13053322091
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admin@mopaikeji.com
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
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025-85563444
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cindy.huang@synzest.com
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Changsha Fuzhen Biotechnology Co.，LTD
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0731-13823398 15111215862
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Olix (Shanghai) Pharmaceutical Technology Co., Ltd
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17316404525 17316404525
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Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
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025-58851090 17714375163
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Chengdu Peter-like Biotechnology Co., Ltd.
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028-81700200 13308200041
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Sangon Biotech (Shanghai) Co.,Ltd.
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400-821-026
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Sales@sangon.com
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Wuhan Jingkang en Biomedical Technology Co., Ltd
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+8613720134139
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orders@jknbiochem.com
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Nantong HI-FUTURE Biology Co., Ltd.
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+undefined18051384581
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sales@chemhifuture.com
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Absin Bioscience Inc.
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Proteintech China
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780750-65-4, AZD-5672Related Search:

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  • AZD-5672
  • UNII-61XQN688TW
  • Benzeneacetamide, N-[1-[(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl]-4-piperidinyl]-N-ethyl-4-(methylsulfonyl)-
  • N-{1-[(3R)-3-(3,5-difluorophenyl)-3-(4-methanesulfonylphenyl)propyl]piperidin-4-yl}-N-ethyl-2-(4-methanesulfonylphenyl)acetamide
  • AZD-5672, 10 mM in DMSO
  • 780750-65-4