ChemicalBook > CAS DataBase List > 2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine

2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine

Product Name
2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine
CAS No.
927871-76-9
Chemical Name
2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine
Synonyms
S107;CS-2452;S-107,S107;S-107; S 10;S107 free base;S 107 hydrochloride;S107, 10 mM in DMSO;2,3,4,5-Tetrahydro-7-methoxy-4-methyl-;RyR-Calstabin Interaction Stabilizer, S107;7-methoxy-4-methyl-3,5-dihydro-2H-1,4-benzothiazepine
CBNumber
CB82506371
Molecular Formula
C11H15NOS
Formula Weight
209.31
MOL File
927871-76-9.mol
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2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine Property

Boiling point:
318.8±42.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 100mg/mL
form 
Solid
pka
7.74±0.20(Predicted)
color 
White to off-white
Water Solubility 
Water : ≥ 132 mg/mL (537.09 mM)
BRN 
18342799
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.00469
Product name
RyR-Calstabin Interaction Stabilizer, S107
Packaging
10 mg
Price
$212
Updated
2025/07/31
AK Scientific
Product number
1331AH
Product name
2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine
Packaging
5mg
Price
$96
Updated
2021/12/16
AK Scientific
Product number
1331AH
Product name
2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine
Packaging
100mg
Price
$163
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM1046160
Product name
2,3,4,5-TETRAHYDRO-7-METHOXY-4-METHYL-1,4-BENZOTHIAZEPINE
Purity
95.00%
Packaging
5MG
Price
$495.48
Updated
2021/12/16
AK Scientific
Product number
1331AH
Product name
2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine
Packaging
1g
Price
$577
Updated
2021/12/16
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2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine Chemical Properties,Usage,Production

Uses

It is a benzothiazepine derivative that binds the RyR1 channel and enhances the binding affinity of Calstabin-1. By preventing the depletion of Calstabin-1 from the RyR1 complex, S 107 slows muscle fatique and reduces muscle damage in exercised mice. In a murine model of Duchenne muscular dystrophy, S 107 reduces biochemical and histological evidence of the muscle damage associated with muscular dystrophy, improves muscle function, and increases exercise performance.

Biological Activity

Primary Target
RyR2

in vivo

S107, which prevents a leak in the channel but does not block the channel or alter normal Ca2+ signaling, is able to inhibit both seizures and arrhythymias in the mutant mice[1].

2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine Suppliers

China 60 China Hong Kong 1 Germany 1 India 1 United States 9 Global 72
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View Lastest Price from 2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine manufacturers

Career Henan Chemical Co
Product
2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine 927871-76-9
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

927871-76-9, 2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepineRelated Search:

2,2-DIMETHYLTETRAHYDROFURAN N-Methyldiethanolamine

  • 2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine
  • S-107; S 10
  • CS-2452
  • 7-methoxy-4-methyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine
  • 2,3,4,5-Tetrahydro-7-methoxy-4-methyl-
  • S 107 hydrochloride
  • S107
  • 1,4-Benzothiazepine, 2,3,4,5-tetrahydro-7-methoxy-4-methyl-
  • S107 free base
  • S-107,S107
  • 7-methoxy-4-methyl-3,5-dihydro-2H-1,4-benzothiazepine
  • S107, 10 mM in DMSO
  • RyR-Calstabin Interaction Stabilizer, S107
  • 927871-76-9
  • API