ChemicalBook > CAS DataBase List > N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide

N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide

Product Name
N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide
CAS No.
90356-78-8
Chemical Name
N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide
Synonyms
BicalutaMide Sulfide;Bicalutamide-EP-Imp-J;Bicalutamide Impurity J;Bicalutamide Intermediate;Bicalutamide EP Impurity J;INTERMEDIATE OF BICALUTAMIDE;N-[4-Cyano-3-(trifluoromethyl);Bicalutamide Impurity 8(EP Impurity J);Bicalutamide intermediate (thio ether);BICALUTAMIDE-SULFIDE (BICALUTAMIDE ASH)
CBNumber
CB8250746
Molecular Formula
C18H14F4N2O2S
Formula Weight
398.37
MOL File
90356-78-8.mol
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N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide Property

Melting point:
109-111°C
Boiling point:
565.6±50.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
12.31±0.29(Predicted)
color 
White
PH
6.45 at 24℃ and 10g/L
InChI
InChI=1S/C18H14F4N2O2S/c1-17(26,10-27-14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
InChIKey
GCGWWKKSGPETMI-UHFFFAOYSA-N
SMILES
C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)(=O)C(O)(C)CSC1=CC=C(F)C=C1
LogP
3.8 at 30℃
CAS DataBase Reference
90356-78-8(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B382040
Product name
BicalutamideSulfide
Packaging
250mg
Price
$120
Updated
2021/12/16
TRC
Product number
B382040
Product name
BicalutamideSulfide
Packaging
1g
Price
$365
Updated
2021/12/16
Biosynth Carbosynth
Product number
IB18585
Product name
Bicalutamide sulfide
Packaging
5G
Price
$450
Updated
2021/12/16
Matrix Scientific
Product number
090739
Product name
N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((4-fluoro-phenyl)thio)-2-hydroxy-2-methylpropanamide
Purity
95+%
Packaging
250mg
Price
$681
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
APN0002253
Product name
N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)THIO]-2-HYDROXY-2-METHYLPROPIONAMIDE
Purity
95.00%
Packaging
250MG
Price
$716.1
Updated
2021/12/16
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N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Bicalutamide intermediate.

Synthesis

371-42-6

90357-51-0

90356-78-8

Example 1 Preparation of N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropanamide: 4-Fluorobenzenethiol (21 g) was dissolved in methanol (65 ml) and cooled to 0°C. 50% aqueous sodium hydroxide solution (14g) was added in batches under stirring. The reaction mixture was stirred at 0°C for 30 min, followed by continued stirring at 25°C for 1 hr. N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyl oxirane amide (40 g) was added to the reaction system and the reaction was stirred at room temperature for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, water (100 ml) was added to the mixture and the pH was adjusted to below 7 with concentrated hydrochloric acid. Methanol was removed by distillation under reduced pressure until no methanol was distilled. The resulting suspension was stirred at 5°C for 3 h. The solid product was collected by filtration and washed with water (2 x 40 ml). Finally, the solid was dried under vacuum at 50-60°C to afford the target product N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropanamide 58 g in 98% yield.

References

[1] Patent: US2007/27211, 2007, A1. Location in patent: Page/Page column 2; 4
[2] Patent: US2003/191337, 2003, A1. Location in patent: Page/Page column 5; 11
[3] Patent: US2013/274501, 2013, A1. Location in patent: Paragraph 0107; 0108; 0109
[4] Patent: US2003/191337, 2003, A1. Location in patent: Page/Page column 5; 11
[5] Patent: US2003/191337, 2003, A1. Location in patent: Page/Page column 12; 13

N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide Suppliers

Canada 1 China 174 Europe 2 Germany 1 India 18 Spain 1 Ukraine 1 United Kingdom 6 United States 20 Global 224
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View Lastest Price from N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide 90356-78-8
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-08-29
Career Henan Chemical Co
Product
N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide 90356-78-8
Price
US $1.00/kg
Min. Order
1kg
Purity
98%min
Supply Ability
as request
Release date
2018-12-23

90356-78-8, N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamideRelated Search:

Mercaptoacetic acid Sodium thioglycolate 6-Mercaptopurine 3-Mercaptopropionic acid CHLOROPHOSPHONAZO III Phenylhydrazine 2-Mercaptobenzothiazole 2-Ethylhexyl mercaptoacetate Calcium thioglycolate Thiosalicylic acid PHENYL VALERATE Bicalutamide Desfluoro Bicalutamide Bicalutamide EP Impurity K BICALUTAMIDE-D4 N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide Deshydroxy Bicalutamide 3-(4-Fluobenzenesulfhydry)-2-hydroxyl-2-methylpropionic acid

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  • 4-CYANO-3-TRIFLUOROMETHYL-N-[3-(4-FLUOROPHENYLTHIO)-2-HYDROXYL-2-METHYLPROPIONYL]ANILINE
  • (S)-N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-(4-FLUOROPHENYLTHIO)-2-HYDROXY-2-METHYLPROPANAMIDE
  • N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)THIO]-2-HYDROXY-2-METHYL PROPANAMIDE
  • N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)THIO]-2-HYDROXY-2-METHYLPROPIONAMIDE
  • Bicalutamide Intermediate
  • BICALUTAMIDE-SULFIDE (BICALUTAMIDE ASH)
  • N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)thio]-2-Hydroxy-2-Methy
  • N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)THIO] -2- HYDROXY-2-MET
  • 4-OYANO-3-TRIFLUOROMETHYL-N-[3-(4-FLUOROPHENYLTHIO)-2-HYDROXYL-2-METHYLPROPIONYL]ANILINE
  • H-(4-CYANO-3-TRIFLUOROMTHYLPHENYL)-3-(4-FLOUROPHENYLSULFANYL)-2-HYDROXY-2-METHYLPROPIONAMIDE
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  • INTERMEDIATE OF BICALUTAMIDE
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  • (2S)-N-[4-cyano-3-(trifluoroMethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-MethylpropanaMide
  • N-[4-Cyano-3-trifluoromethy phenyl]-S-(4-fluorophenylthio)-2-hydrdoxy-2-methyl-propionamide
  • Bicalutamide Impurity 8(EP Impurity J)
  • Bicalutamide-EP-Imp-J
  • N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Thio]-2-Hydroxy-2-Methylpropionamid
  • Bicalutamide EP Impurity J (Bicalutamide Sulfide)
  • N-[4-Cyano-3-(Trifluoromethyl)phenyl]-3-[(4-Fluorophenyl)thio]-2-Hydroxy-2-Methyl
  • Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methyl-
  • Bicalutamide Impurity 8(Bicalutamide EP Impurity J)
  • N-[4-cyano-3-tri?uoromethylphenyl]-3-[4-?uorophenylthio]-2- hydroxy-2methylpropionamide
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  • 3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamideQ: What is 3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamide Q: What is the CAS Number of 3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamide Q: What is the storage condition of 3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamide Q: What are the applications of 3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamide
  • Bicalutamide intermediate (thio ether) N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide
  • Bicalutamide Impurity J
  • N - [4-Cyano-3- (trifluoromethyl) phenyl] -3- (4-fluorophenylthiol) -2-hydroxy-2-methylpropanamide
  • 4-Cyano-3-trifluoromethyl-N-[3-(4-fluorophenyl)thio-2-hydroxy-2-methylpropionyl]aniline
  • Bicalutamide intermediate (thio ether)
  • N-[4-Cyano-3- (trifluoromethyl)phenyl]-3- [(4-fluorophenyl)thio]-2-
  • N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide
  • (2RS)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanami
  • (2RS)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide
  • 90356-78-8
  • 90326-78-8
  • C18H14F4N2O2S
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Bicalutamide
  • (intermediate of bicalutamide)