ChemicalBook > CAS DataBase List > BKM120 (NVP-BKM120, Buparlisib)

BKM120 (NVP-BKM120, Buparlisib)

Product Name
BKM120 (NVP-BKM120, Buparlisib)
CAS No.
944396-07-0
Chemical Name
BKM120 (NVP-BKM120, Buparlisib)
Synonyms
isib;100821;CS-227;BuparL;AN-2025;Buparlisib;BKM120BASE;NVP-BKM-120;BKM120, >=98%;NVP-BKM120, BKM120
CBNumber
CB82509983
Molecular Formula
C18H21F3N6O2
Formula Weight
410.39
MOL File
944396-07-0.mol
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BKM120 (NVP-BKM120, Buparlisib) Property

Melting point:
143-147°C
Boiling point:
645.7±65.0 °C(Predicted)
Density 
1.382
storage temp. 
-20°C
solubility 
Soluble in DMSO (15 mg/ml)
form 
White powder.
pka
5.94±0.50(Predicted)
color 
White
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H341Suspected of causing genetic defects

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11587
Product name
NVP-BKM120
Purity
≥95%
Packaging
5mg
Price
$26
Updated
2024/03/01
Cayman Chemical
Product number
11587
Product name
NVP-BKM120
Purity
≥95%
Packaging
50mg
Price
$141
Updated
2024/03/01
Cayman Chemical
Product number
11587
Product name
NVP-BKM120
Purity
≥95%
Packaging
1mg
Price
$31
Updated
2023/06/20
Cayman Chemical
Product number
11587
Product name
NVP-BKM120
Purity
≥95%
Packaging
10mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
11587
Product name
NVP-BKM120
Purity
≥95%
Packaging
25mg
Price
$102
Updated
2024/03/01
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BKM120 (NVP-BKM120, Buparlisib) Chemical Properties,Usage,Production

Description

Buparlisib (944396-07-0) is potent pan-Class I PI3-kinase inhibitor (IC50’s: p110α = 52 nM, p110? = 166 nM, p110δ = 116 nM. P110g = 262 nM).1,2 It inhibited microtubule dynamics at in vitro concentrations >1μM and doses above 50mg/kg in mice.3 Buparlisib lead to a precipitous drop in DNA synthesis in a mouse model of BRCA1-linked triple-negative breast cancer with less affect in normal tissue.4

Uses

A selective Class I PI3K inhibitor of p110α, p110β, p110δ and p110γ with IC50s of 50-300 nM.

Uses

NVP-BKM 120 is a novel anti-tumor active compound that is selective in that it inhibits specifically PI3 kinase activating cell death in glioma cells. Glioma cells being those that proliferate from tumors in the brain or the spine.

Definition

ChEBI: BKM120 is an aminopyridine that is 4-(trifluoromethyl)pyridin-2-amine substituted at position 5 by a 2,6-di(morpholin-4-yl)pyrimidin-4-y group. A selective PI3K inhibitor with anti-tumour properties. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an antineoplastic agent. It is a member of morpholines, an aminopyrimidine, an aminopyridine and an organofluorine compound.

target

p110α

References

Burger et al. (2011), Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer; ACS Med. Chem. Lett. 2 774 Maira et al. (2012), Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor; Mol. Cancer Ther. 11 317 Brachmann et al. (2012), Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations; Mol. Cancer Ther. 11 1747 Juvekar et al. (2016), Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion; Proc. Natl. Acad. Sci USA. 113 E4338

BKM120 (NVP-BKM120, Buparlisib) Preparation Products And Raw materials

Raw materials

Preparation Products

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BKM120 (NVP-BKM120, Buparlisib) Suppliers

Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
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View Lastest Price from BKM120 (NVP-BKM120, Buparlisib) manufacturers

Zhejiang J&C Biological Technology Co.,Limited
Product
NVP-BKM-120 944396-07-0
Price
US $0.00/gram
Min. Order
1gram
Purity
99%
Supply Ability
10kg
Release date
2022-02-17
Career Henan Chemical Co
Product
BKM120 (NVP-BKM120, Buparlisib) 944396-07-0
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

944396-07-0, BKM120 (NVP-BKM120, Buparlisib)Related Search:


  • 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine
  • 5-(2,6-diMorpholinopyriMidin-4-yl)-4-(trifluoroMethyl)pyridin-2-aMine
  • BKM120 (NVP-BKM120)
  • NVP-BKM-120
  • BKM120 (NVP-BKM120, Buparlisib)
  • NVP-BKM120, Buparlisib
  • BKM120BASE
  • Buparlisib
  • BKM-120 4-(2,6-diMorpholinopyriMidin-4-yl)-3-(trifluoroMethyl)aniline
  • 5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine
  • AN-2025
  • 100821
  • CS-227
  • NVP-BKM120,Buparlisib,BKM120, >98%
  • NVP-BKM-120; BKM-120; BUPARLISIB
  • 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine BKM120 (NVP-BKM120, Buparlisib)
  • NVP-BKM-120 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine
  • NVP-BKM120, BKM120
  • BKM120, >=98%
  • BKM120 (Buparlisib)
  • 5-(2,6-dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine BKM120
  • 2-Pyridinamine, 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-
  • Buparlisib, 98%, a selective PI3K inhibitor
  • Buparlisib (BKM120, NVP-BKM120)
  • NVP-BKM-120; BKM-120;BUPARLISIB;BKM120;BKM 120
  • BuparL
  • isib
  • BKM120 (NVP-BKM120, Buparlisib) USP/EP/BP
  • NVP-BKM120,Buparlisib,BKM120
  • 944396-07-0
  • C18H21O2N6F3
  • C18H21F3N6O2
  • Akt
  • mTOR
  • PI3K
  • Inhibitors
  • Inhibitor
  • API