5-Cyano-2-methylphenylboronic acid
- Product Name
- 5-Cyano-2-methylphenylboronic acid
- CAS No.
- 867333-43-5
- Chemical Name
- 5-Cyano-2-methylphenylboronic acid
- Synonyms
- 5-Cyano-2-methylphenylboronic acid;Boronicacid,B-(5-cyano-2-methylphenyl)-;(5-Cyano-2-methylphenyl)boronic acid 97%;(5-Cyano-2-methylphenyl)boronic acid(contains varying amounts of Anhydride)
- CBNumber
- CB82513500
- Molecular Formula
- C8H8BNO2
- Formula Weight
- 160.97
- MOL File
- 867333-43-5.mol
5-Cyano-2-methylphenylboronic acid Property
- Boiling point:
- 373.4±52.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 7.25±0.58(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- C987678
- Product name
- 5-Cyano-2-methylphenylboronicacid
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC42853
- Product name
- 5-Cyano-2-methylphenylboronic acid
- Packaging
- 100mg
- Price
- $83
- Updated
- 2021/12/16
- Product number
- OR360278
- Product name
- (5-Cyano-2-methylphenyl)boronicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $116
- Updated
- 2021/12/16
- Product number
- FC42853
- Product name
- 5-Cyano-2-methylphenylboronic acid
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FC42853
- Product name
- 5-Cyano-2-methylphenylboronic acid
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
5-Cyano-2-methylphenylboronic acid Chemical Properties,Usage,Production
Synthesis
121-43-7
42872-74-2
867333-43-5
Step 1: Synthesis of 5-cyano-2-methylphenylboronic acid First, 9.5 g (50 mmol) of 3-bromo-4-methylbenzonitrile was placed in a 500 mL three-necked flask and the atmosphere inside the flask was replaced with nitrogen. Then, 250 mL of tetrahydrofuran (THF) was added and the mixture was stirred at -78 °C for 30 min. Slowly 34 mL (55 mmol) of 1.63 M hexane solution of n-butyllithium (n-BuLi) was added dropwise to the above mixture and the reaction was maintained at -78 °C for 1.5 hours. Subsequently, 7.3 mL (65 mmol) of trimethyl borate was added to the reaction system, and the reaction solution was slowly warmed to room temperature and stirred for 20 hours. Upon completion of the reaction, 100 mL of 1 M hydrochloric acid was added to the system and stirred for 30 minutes. The reaction mixture was transferred to a partition funnel and the aqueous and organic layers were separated. The aqueous layer was extracted with ethyl acetate, the organic phase and extract were combined and washed with saturated sodium chloride solution. Anhydrous magnesium sulfate was added to the washed organic phase to dry. After drying, gravity filtration was performed and the filtrate was concentrated to obtain the crude product. The crude product was washed with toluene and hexane to give 4.3 g of white solid in 53% yield. The resulting white solid was confirmed to be 5-cyano-2-methylphenylboronic acid by nuclear magnetic resonance (NMR) spectral analysis. The synthesis scheme of step 1 is shown below (a-10).
References
[1] Patent: WO2016/203350, 2016, A1. Location in patent: Paragraph 1195
[2] Journal of the American Chemical Society, 2002, vol. 124, # 31, p. 9014 - 9015
5-Cyano-2-methylphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Cyano-2-methylphenylboronic acid manufacturers
- Product
- 5-Cyano-2-methylphenylboronic acid 867333-43-5
- Price
- US $34.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08