(4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid
- Product Name
- (4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid
- CAS No.
- 1061223-45-7
- Chemical Name
- (4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid
- Synonyms
- Tavaborole Impurity 14;(4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid;B-[4-Fluoro-2-(hydroxymethyl)phenyl]boronic acid;Boronic acid, B-[4-fluoro-2-(hydroxymethyl)phenyl]-
- CBNumber
- CB12631542
- Molecular Formula
- C7H8BFO3
- Formula Weight
- 169.95
- MOL File
- 1061223-45-7.mol
(4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid Property
- Melting point:
- 14-128°C
- Boiling point:
- 361.2±52.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- pka
- 8.62±0.58(Predicted)
- form
- Solid
- color
- White to Off-White
Safety
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F595308
- Product name
- 4-Fluoro-2-(hydroxymethyl)phenylboronicAcid
- Packaging
- 500mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- F595308
- Product name
- 4-Fluoro-2-(hydroxymethyl)phenylboronicAcid
- Packaging
- 1g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- BOR0006859
- Product name
- (4-FLUORO-2-(HYDROXYMETHYL)PHENYL)BORONIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $289.8
- Updated
- 2021/12/16
- Product number
- Z6840
- Product name
- 4-Fluoro-2-(hydroxymethyl)phenylboronicacid
- Packaging
- 1g
- Price
- $234
- Updated
- 2021/12/16
- Product number
- Z6840
- Product name
- 4-Fluoro-2-(hydroxymethyl)phenylboronicacid
- Packaging
- 25g
- Price
- $2406
- Updated
- 2021/12/16
(4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid Chemical Properties,Usage,Production
Uses
4-Fluoro-2-(hydroxymethyl)phenylboronic Acid is a compound used in the preparation of 4,5-dihydro-1H-pyrazole derivatives as cholesterol 24 hydroxylase inhibitors.
Synthesis
13675-18-8
202865-66-5
1061223-45-7
GENERAL STEPS: To a solution of 2-bromo-5-fluorobenzyl alcohol (10.05 g, 49 mmol) in anhydrous ethanol (100 mL) was sequentially added NiCl2(dppp) (2.67 g, 4.9 mmol), tetrahydroxydiboron (6.62 g, 74 mmol), triphenylphosphine (0.01 mol), and N,N-diisopropylethylamine (25.7 mL. 148 mmol). The reaction system was degassed under nitrogen protection for 10 min. Subsequently, the reaction mixture was heated to reflux and stirred for 4 hours. After completion of the reaction, it was cooled to room temperature, diluted with water (100 mL) and extracted with ethyl acetate (3 × 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to give the crude product 4-fluoro-2-(hydroxymethyl)phenylboronic acid (6), which was used directly in the next step of the reaction. After purification by column chromatography, the target compound was obtained (yield: 62%).
References
[1] Patent: WO2017/183043, 2017, A1. Location in patent: Page/Page column 33
(4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid Suppliers
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16075
- Advantage
- 64
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9342
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- 0411-62313318 13942603642
- Fax
- 0411-87549748
- info@allychem.com
- Country
- China
- ProdList
- 1028
- Advantage
- 65
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 010-010-15313962280 15313962280
- Fax
- 010-51669040
- 3004509780@qq.com
- Country
- China
- ProdList
- 824
- Advantage
- 55
View Lastest Price from (4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid manufacturers
- Product
- (4-FLUORO-2-(HYDROXYMETHYL)PHENYL)BORONIC ACID 1061223-45-7
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-07-04
- Product
- (4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid 1061223-45-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26