Boronic acid, (4-cyano-3-methoxyphenyl)- (9CI)
- Product Name
- Boronic acid, (4-cyano-3-methoxyphenyl)- (9CI)
- CAS No.
- 677777-45-6
- Chemical Name
- Boronic acid, (4-cyano-3-methoxyphenyl)- (9CI)
- Synonyms
- 4-Cyano-3-methoxybenzene boronic acid;4-Cyano-3-methoxyphenylboronic acid 97%;Boronic acid, B-(4-cyano-3-methoxyphenyl)-;4-Cyano-3-Methoxyphenylboronic Acid(WX650131);Boronic acid, (4-cyano-3-methoxyphenyl)- (9CI);(4-Cyano-3-methoxyphenyl)boronic acid (contains varying amounts of Anhydride)
- CBNumber
- CB51060563
- Molecular Formula
- C8H8BNO3
- Formula Weight
- 176.96
- MOL File
- 677777-45-6.mol
Boronic acid, (4-cyano-3-methoxyphenyl)- (9CI) Property
- Boiling point:
- 417.6±55.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 6.90±0.10(Predicted)
- form
- solid
- color
- White to off-white
Safety
- RIDADR
- 3439
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- C982188
- Product name
- 4-Cyano-3-methoxyphenylboronicacid
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C982188
- Product name
- 4-Cyano-3-methoxyphenylboronicacid
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 126624
- Product name
- (4-Cyano-3-methoxyphenyl)boronicacid
- Purity
- >95%
- Packaging
- 1g
- Price
- $576
- Updated
- 2021/12/16
- Product number
- X0936
- Product name
- 4-Cyano-3-methoxyphenylboronicacid
- Packaging
- 5g
- Price
- $771
- Updated
- 2021/12/16
- Product number
- FC160629
- Product name
- 4-Cyano-3-methoxyphenylboronic acid
- Packaging
- 100mg
- Price
- $88
- Updated
- 2021/12/16
Boronic acid, (4-cyano-3-methoxyphenyl)- (9CI) Chemical Properties,Usage,Production
Synthesis
330793-38-9
677777-45-6
The general procedure for the synthesis of (4-cyano-3-methoxyphenyl)boronic acid from 2-methoxy-4-bromobenzonitrile was as follows: an overhead mechanical stirrer and a nitrogen inlet tube were assembled in a 1L three-necked round-bottomed flask. To the reaction flask was added 45.56 g (215 mmol) of 4-bromo-2-methoxybenzonitrile, 64 mL (277 mmol) of triisopropyl borate, and 500 mL of anhydrous THF.The reaction system was cooled to -78 °C in a dry ice/acetone bath. A n-butyllithium solution (2.5 M in hexane, 110 mL, 275 mmol) was slowly added dropwise through a constant pressure dropping funnel. After dropwise addition, the reaction was maintained at -78 °C with continued stirring for 30 min, followed by addition of 2N hydrochloric acid solution to quench the reaction. The reaction mixture was stirred at room temperature for 1 h and then poured into ice water. The aqueous phase was extracted three times with ether (Et2O). The organic phases were combined and back-extracted with 1N sodium hydroxide solution. The alkaline aqueous phase was washed with ether and acidified with concentrated hydrochloric acid to pH < 2. The acidified aqueous phase was again extracted with ether. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 20.77 g (55% yield) of the target product (4-cyano-3-methoxyphenyl)boronic acid as a white solid. The product was characterized by 1H NMR (500 MHz, d6-DMSO): δ 7.68 (d, J=8.0 Hz, 1H), 7.59 (s, 1H), 7.47 (d, J=8.0 Hz, 1H), 3.95 (s, 3H).
References
[1] Patent: WO2005/95400, 2005, A1. Location in patent: Page/Page column 341
Boronic acid, (4-cyano-3-methoxyphenyl)- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
Boronic acid, (4-cyano-3-methoxyphenyl)- (9CI) Suppliers
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 18681884732
- Fax
- 021-51632502
- 2245256225@qq.com
- Country
- China
- ProdList
- 1728
- Advantage
- 50
- Tel
- 400-8592883
- Fax
- 0731-82251112
- sales@huatengsci.com
- Country
- China
- ProdList
- 5872
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 0519-85528066 13775048983
- Fax
- 0519-85528066
- sales@hopschem.com
- Country
- China
- ProdList
- 31553
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58