4-Cyanophenylboronic acid
Description Reference- Product Name
- 4-Cyanophenylboronic acid
- CAS No.
- 126747-14-6
- Chemical Name
- 4-Cyanophenylboronic acid
- Synonyms
- SWF-108;AKOS BRN-0076;CHEMBRDG-BB 3200965;RARECHEM AH PB 0209;4-Boronobenzonitrile;4-Cyanophenylboronic;4-cyanobboronic acid;4-Cyanophenylboric acid;4-Cyanophenylboronicaci;2-Cyanophenylboroic acid
- CBNumber
- CB8283302
- Molecular Formula
- C7H6BNO2
- Formula Weight
- 146.94
- MOL File
- 126747-14-6.mol
4-Cyanophenylboronic acid Property
- Melting point:
- >350 °C (lit.)
- Boiling point:
- 355.9±44.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO, Methanol (Slightly)
- pka
- 7.38±0.10(Predicted)
- form
- Powder
- color
- White to yellow
- BRN
- 6593772
- CAS DataBase Reference
- 126747-14-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-37/39-26-36
- RIDADR
- UN3439
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 521418
- Product name
- 4-Cyanophenylboronic acid
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $40.38
- Updated
- 2024/03/01
- Product number
- 521418
- Product name
- 4-Cyanophenylboronic acid
- Purity
- ≥95%
- Packaging
- 10g
- Price
- $144.8
- Updated
- 2024/03/01
- Product number
- C1778
- Product name
- 4-Cyanophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $19
- Updated
- 2024/03/01
- Product number
- C1778
- Product name
- 4-Cyanophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $45
- Updated
- 2024/03/01
- Product number
- L18007
- Product name
- 4-Cyanobenzeneboronic acid, 98%
- Packaging
- 1g
- Price
- $52.65
- Updated
- 2024/03/01
4-Cyanophenylboronic acid Chemical Properties,Usage,Production
Description
4-Cyanophenylboronic acid can be used for palladium catalyzed Suzuki cross-coupling reactions to synthesize 6-acryl-2,4-diamino-pyrimidines and triazines. It is used as precursor in the synthesis of inhibitors such as Tpl2 kinase inhibitors and P2X7 antagonists used in the treatment of pain. It is also a reagent used for preparation of himbacine analogs as thrombin receptor antagonists and potential antiplatelet agents, trisulfonated calixarene upper-rim sulfonamido and their complexation with trimethyllysine epigenetic mark, antimalarial compounds via Suzuki cross-coupling, and deoxyuridine derivatives.
Reference
- G. Cooke, H. A. de Cremiers, V. M. Rotello, B. Tarbit, P. E. Vandersträten, Synthesis of 6-aryl-2,4-diamino-pyrimidines and triazines using palladium catalysed Suzuki cross-coupling reactions, Tetrahedron, 2001, vol. 57, pp. 2787-2789
- N. Ni, H. Chou, J. Wang, M. Li, C. Lu, P. C. Tai, B. Wang, Identification of boronic acids as antagonists of bacterial quorum sensing in Vibrio harveyi, Biochemical and Biophysical Research Communications, 2008, vol. 369, pp. 590-594
Chemical Properties
white to yellow powder
Uses
suzuki reaction
Uses
4-Cyanophenylboronic Acid is a reactant used in the synthesis of (AMG-8718), an inhibitor of β-site amyloid precursor protein cleaving enzyme (BACE1).
Uses
Intermediates of Liquid Crystals
4-Cyanophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Cyanophenylboronic acid manufacturers
- Product
- 4-Cyanophenylboronic acid 126747-14-6
- Price
- US $34.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 4-Cyanophenylboronic acid 126747-14-6
- Price
- US $35.00-25.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 Ton
- Release date
- 2023-10-30
- Product
- 4-Cyanophenylboronic acid 126747-14-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 30000 Kg
- Release date
- 2023-11-30