ChemicalBook > CAS DataBase List > (4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid

(4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid

Product Name: (4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid
CAS No.: 1061223-45-7
Chemical Name: (4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid
Synonyms: Tavaborole Impurity 14;(4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid;B-[4-Fluoro-2-(hydroxymethyl)phenyl]boronic acid;Boronic acid, B-[4-fluoro-2-(hydroxymethyl)phenyl]-
CBNumber: CB12631542
Molecular Formula: C7H8BFO3
Formula Weight: 169.95
MOL File: 1061223-45-7.mol

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(4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid Property

Melting point:: 14-128°C
Boiling point:: 361.2±52.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
pka: 8.62±0.58(Predicted)
form: Solid
color: White to Off-White

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Safety

HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F595308
Product name: 4-Fluoro-2-(hydroxymethyl)phenylboronicAcid
Packaging: 500mg
Price: $275
Updated: 2021/12/16

TRC

Product number: F595308
Product name: 4-Fluoro-2-(hydroxymethyl)phenylboronicAcid
Packaging: 1g
Price: $495
Updated: 2021/12/16

AK Scientific

Product number: Z6840
Product name: 4-Fluoro-2-(hydroxymethyl)phenylboronicacid
Packaging: 1g
Price: $234
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0006859
Product name: (4-FLUORO-2-(HYDROXYMETHYL)PHENYL)BORONIC ACID
Purity: 95.00%
Packaging: 1G
Price: $289.8
Updated: 2021/12/16

AK Scientific

Product number: Z6840
Product name: 4-Fluoro-2-(hydroxymethyl)phenylboronicacid
Packaging: 25g
Price: $2406
Updated: 2021/12/16

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(4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid Chemical Properties,Usage,Production

Uses

4-Fluoro-2-(hydroxymethyl)phenylboronic Acid is a compound used in the preparation of 4,5-dihydro-1H-pyrazole derivatives as cholesterol 24 hydroxylase inhibitors.

Synthesis

13675-18-8

202865-66-5

1061223-45-7

GENERAL STEPS: To a solution of 2-bromo-5-fluorobenzyl alcohol (10.05 g, 49 mmol) in anhydrous ethanol (100 mL) was sequentially added NiCl2(dppp) (2.67 g, 4.9 mmol), tetrahydroxydiboron (6.62 g, 74 mmol), triphenylphosphine (0.01 mol), and N,N-diisopropylethylamine (25.7 mL. 148 mmol). The reaction system was degassed under nitrogen protection for 10 min. Subsequently, the reaction mixture was heated to reflux and stirred for 4 hours. After completion of the reaction, it was cooled to room temperature, diluted with water (100 mL) and extracted with ethyl acetate (3 × 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to give the crude product 4-fluoro-2-(hydroxymethyl)phenylboronic acid (6), which was used directly in the next step of the reaction. After purification by column chromatography, the target compound was obtained (yield: 62%).

References

[1] Patent: WO2017/183043, 2017, A1. Location in patent: Page/Page column 33

(4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (4-FLUORO-2-(HYDROXYMETHYL)PHENYL)BORONIC ACID 1061223-45-7
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-04

Career Henan Chemical Co

Product: (4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid 1061223-45-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

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(4-Fluoro-2-(hydroxyMethyl)phenyl)boronic acid

Tavaborole Impurity 14

Boronic acid, B-[4-fluoro-2-(hydroxymethyl)phenyl]-

B-[4-Fluoro-2-(hydroxymethyl)phenyl]boronic acid

1061223-45-7