Niraparib
Uses- Product Name
- Niraparib
- CAS No.
- 1038915-60-4
- Chemical Name
- Niraparib
- Synonyms
- (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide;MK-4827 98.00%;Niraparib (MK-4827);CS-2299;iraparib;Niraparib;EOS-60867;Niraparib base;MK4827 (Niraparib);Niraparib USP/EP/BP
- CBNumber
- CB82514860
- Molecular Formula
- C19H20N4O
- Formula Weight
- 320.39
- MOL File
- 1038915-60-4.mol
Niraparib Property
- Melting point:
- 187-189°C
- Boiling point:
- 463.6±45.0 °C(Predicted)
- Density
- 1.34
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 15.36±0.30(Predicted)
- form
- Solid
- color
- Pale Yellow to Light Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N481400
- Product name
- Niraparib
- Packaging
- 2.5mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- A3617
- Product name
- MK-4827
- Packaging
- 50mg
- Price
- $490
- Updated
- 2021/12/16
- Product number
- 153552
- Product name
- (S)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
- Purity
- 95%
- Packaging
- 5mg
- Price
- $556
- Updated
- 2021/12/16
- Product number
- A3617
- Product name
- MK-4827
- Packaging
- 100mg
- Price
- $740
- Updated
- 2021/12/16
- Product number
- OR321439
- Product name
- (S)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
- Purity
- 99%
- Packaging
- 5g
- Price
- $790
- Updated
- 2021/12/16
Niraparib Chemical Properties,Usage,Production
Uses
Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
Description
(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide is also known as MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 (The poly(ADP-ribose) polymerase) with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It has been recently approved by FDA for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy. In vitro studies have shown that niraparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, apoptosis and cell death.
Uses
Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
Definition
ChEBI: Niraparib is a 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy. It has a role as an antineoplastic agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a radiosensitizing agent and an apoptosis inducer.
Pharmacology
The synthesis and initial pharmacology of niraparib have been published. Niraparib has affinity for PARP 1 and 2 inhibition (IC50 = 3.8 and 2.1 nM, respectively) and inhibits the proliferation of cancer cells with mutant BRCA1 and BRCA2 with IC50 values in the 10–100 nM range in vitro. Niraparib demonstrated efficacy as a single agent in a xenograft model of BRCA1-deficient cancer. Niraparib has also been reported to act as a preclinical radiosensitiser and has entered into clinical oncology trials.
in vitro
mk-4827displayed excellent parp 1 and 2 inhibition with ic50 of 3.8 and 2.1 nm, respectively. in a whole cell assay, mk-4827 inhibited parp activity with ec50 of 4 nm. mk-4827 also inhibited proliferation of cancer cells with mutant brca-1 and brca-2 with cc50 in the 10-100 nm range[1].
in vivo
in a variety of human tumor xenografts of differing p53 status,mk-4827 showed high potential to improve the efficacy of radiotherapy,such as calu-6 (p53 null), a549 (p53 wild-type [wt]) and h-460 (p53 wt) lung cancers and triple negative mda-mb-231 human breast carcinoma [3].
References
https://newdrugapprovals.org/2016/12/22/niraparib-mk-4827/
https://www.fda.gov/drugs/informationondrugs/approveddrugs/ucm548487.htm
https://www.drugbank.ca/drugs/DB11793
Sandhu, Shahneen K, et al. "The poly (ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA, mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial." Lancet Oncology14.9 (2013):882.
Jones, P, et al. "Niraparib: A Poly (ADP-ribose) Polymerase (PARP) Inhibitor for the Treatment of Tumors with Defective Homologous Recombination. " Journal of Medicinal Chemistry 58.8(2015):3302-14.
Niraparib Preparation Products And Raw materials
Raw materials
Preparation Products
Niraparib Suppliers
- Tel
- 18962082606
- Fax
- QQ: 3394205705
- 3394205705@qq.com
- Country
- China
- ProdList
- 1751
- Advantage
- 58
- Tel
- 18122150900
- Fax
- QQ:2869377561
- sculk28@163.com
- Country
- China
- ProdList
- 646
- Advantage
- 55
- Tel
- 025-85451006; 18795969897
- 3066995499@qq.com
- Country
- China
- ProdList
- 83
- Advantage
- 58
- Tel
- 0556-5032870 15705561919
- Fax
- 0556-5032869
- sujuan.mei@nuoquanpharm.com
- Country
- China
- ProdList
- 94
- Advantage
- 55
- Tel
- 519-88821493 18915891730
- shm@czpharma.com
- Country
- China
- ProdList
- 163
- Advantage
- 58
- Tel
- 13989459766 17767198890
- sales@runyanpharma.com
- Country
- China
- ProdList
- 425
- Advantage
- 58
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6005
- Advantage
- 61
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 86-25-57062118
- Fax
- 86-25-57065896
- sales@jspsn.com
- Country
- China
- ProdList
- 496
- Advantage
- 57
- Tel
- 021-53292253
- Fax
- 021-53292253
- biz@synches.com
- Country
- China
- ProdList
- 199
- Advantage
- 64
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4727
- Advantage
- 58
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9478
- Advantage
- 58
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
- Fax
- +86-27-87599188
- Country
- China
- ProdList
- 1493
- Advantage
- 55
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 021-58958002 18930822973
- Fax
- +86 (21) 5895-8628
- sales@uhnshanghai.com
- Country
- China
- ProdList
- 997
- Advantage
- 58
- Tel
- 400-6206333 18021050169
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-68187180-819 13681683526
- Fax
- 021-68187179
- lchen@syncozymes.com
- Country
- China
- ProdList
- 239
- Advantage
- 55
- Tel
- sales@witofly.com
- Country
- China
- ProdList
- 2864
- Advantage
- 52
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4674
- Advantage
- 55
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 0531-85828981
- Fax
- +86-531-85806006
- 864598798@qq.com
- Country
- China
- ProdList
- 588
- Advantage
- 58
- Tel
- 18051538752
- 3755454181@qq.com
- Country
- China
- ProdList
- 438
- Advantage
- 55
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3466
- Advantage
- 58
- Tel
- 0371-13526885213 15637198702
- Fax
- 0371-63709726
- xpkchem@163.com
- Country
- China
- ProdList
- 3980
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18097
- Advantage
- 56
- Tel
- 0519-83984084
- Fax
- 0519-88776993
- sales@ydpharm.com
- Country
- China
- ProdList
- 119
- Advantage
- 60
- Tel
- 0571-+86-571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 11662
- Advantage
- 59
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- 021-58581007 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
- ProdList
- 2384
- Advantage
- 58
- Tel
- 021-57898186
- Fax
- 021-37699262
- Country
- China
- ProdList
- 449
- Advantage
- 55
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- 13656237714 13656237714
- Fax
- 0512-65852853
- xiaokunfu@kyyykj.com
- Country
- China
- ProdList
- 297
- Advantage
- 55
- Tel
- 021-021-58111628 15800915896
- Fax
- QQ 3285589261
- sales@twochem.com
- Country
- China
- ProdList
- 304
- Advantage
- 55
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 17687
- Advantage
- 55
- Tel
- +86-400-851-9921
- Fax
- +86-10-82826195
- sales@pharmacodia.com
- Country
- China
- ProdList
- 2317
- Advantage
- 55
- Tel
- 021-50908862，442785678，326799392 18721037013
- Fax
- 021-50908862
- siyansales@126.com
- Country
- China
- ProdList
- 9627
- Advantage
- 58
- Tel
- 021-51619050 13301662590
- Fax
- +86-21-51619052
- mandy@atkchemical.com
- Country
- China
- ProdList
- 7776
- Advantage
- 55
- Tel
- 052386810091
- zcwy9518@yeah.net
- Country
- China
- ProdList
- 3899
- Advantage
- 58
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3866
- Advantage
- 58
- Tel
- 021-20242659 18930833303
- Fax
- +86 (21) 2024-2659
- Sales@changyanchem.cn
- Country
- China
- ProdList
- 5010
- Advantage
- 55
- Tel
- 025-83453382-8005
- Fax
- 025-83453382
- sale@parabiochem.com
- Country
- China
- ProdList
- 9595
- Advantage
- 55
- Tel
- 0317-5296180 15533709196
- Fax
- 0317-5106596
- sale@enkepharma.com
- Country
- China
- ProdList
- 2007
- Advantage
- 55
- Tel
- 400-1166-196 18502815961
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 14603
- Advantage
- 60
- Tel
- Fax
- -
- 13006575422@163.com
- Country
- China
- ProdList
- 6355
- Advantage
- 58
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- lucy@atkchemical.com
- Country
- China
- ProdList
- 9987
- Advantage
- 58
View Lastest Price from Niraparib manufacturers
- Product
- Niraparib 1038915-60-4
- Price
- US $0.00-0.00/g
- Min. Order
- 10000g
- Purity
- 99% HPLC
- Supply Ability
- 1000kg
- Release date
- 2024-09-11
- Product
- Niraparib 1038915-60-4
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-05-07
- Product
- Niraparib 1038915-60-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%, Single impurity＜0.1
- Supply Ability
- 1 ton
- Release date
- 2023-12-25