ChemicalBook > CAS DataBase List > 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

Product Name
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
CAS No.
694499-26-8
Chemical Name
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
Synonyms
PON50;SW-53;SWF-53;Ponatinib int2;Ponatinib Impurity 3;Pralsetinib Impurity 1;Intermediate of Ponatinib;4-(4-Methylpiperazinomethyl)-3-;4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline;4-(4-Methylpiperazinomethyl)-4-(trifluoromethyl)aniline
CBNumber
CB92520701
Molecular Formula
C13H18F3N3
Formula Weight
273.3
MOL File
694499-26-8.mol
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4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Property

Boiling point:
329.1±42.0 °C(Predicted)
Density 
1.227
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
7.55±0.10(Predicted)
InChI
InChI=1S/C13H18F3N3/c1-18-4-6-19(7-5-18)9-10-2-3-11(17)8-12(10)13(14,15)16/h2-3,8H,4-7,9,17H2,1H3
InChIKey
ZMWAZMYBMAAMAW-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
M329373
Product name
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
Packaging
5g
Price
$250
Updated
2021/12/16
Matrix Scientific
Product number
132323
Product name
4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline
Purity
97%
Packaging
25g
Price
$2700
Updated
2021/12/16
Apolloscientific
Product number
PC51192
Product name
4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline
Purity
95+%
Packaging
1g
Price
$17
Updated
2021/12/16
Oakwood
Product number
212607
Product name
4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline
Purity
95%
Packaging
1g
Price
$19
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-3-3G
Product name
4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline
Purity
95.0%
Packaging
1g
Price
$28
Updated
2021/12/16
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4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Chemical Properties,Usage,Production

Uses

4-(6-Acryloyloxyhexyloxy)-benzoesure (4-cyanophenylester) can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and in the process of chemical and pharmaceutical synthesis.

Synthesis


4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline Into a solution 4-methyl-1-(4-nitro-2-(trifluoromethyl)benzyl)piperazine (1.5 g, 5 mmol) in MeOH (250 mL) was added Raney Nickel (0.15 g, 10 wt %). The suspension was stirred under hydrogen atmosphere (50 psi) for 24 hrs and monitored by TLC. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure to yield the desired product (1.36 g, 100%). 1H NMR (300 MHz, CDCl3) |?: 7.43-7.46 (1H, d, J=9.0 Hz), 6.91 (1H, s), 6.77-6.80 (1H, d J=9.0 Hz), 3.77 (2H, s), 3.54 (2H, s), 2.53 (8H, brs), 2.34 (3H, s).

storage

Store long-term at 2-8°C.

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Suppliers

China 224 India 4 United Kingdom 1 United States 9 Global 238
Shandong Mopai Biotechnology Co., Ltd
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View Lastest Price from 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline manufacturers

Dorne Chemical Technology co. LTD
Product
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline 694499-26-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-06-25
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline 694499-26-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
PNP Biotech Co. Ltd
Product
4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline 694499-26-8
Price
US $0.00/KG
Min. Order
25KG
Purity
98%
Supply Ability
Inquiry
Release date
2022-09-19

694499-26-8, 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)anilineRelated Search:

1-Methyl-4-[[4-nitro-2-(trifluoromethyl)phenyl]methyl]-piperazine 1-(bromomethyl)-4-nitro-2-(trifluoromethyl)benzene 5-BROMO-2-METHYL-3-NITROPHENYL METHYLCARBOXYLATE 2,4-dichloro-7H-Pyrrolo[2,3-d]pyriMidine-7-carboxylic acid 1,1-diMethylethyl ester 1-METHYL-5-NITRO-1H-INDAZOLE 5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE rac-4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl No Chinese name (6-Methylpyridazin-3-yl)MethanaMine dihydrochloride tert-butyl 4-(4-broMothiazol-2-yl)piperazine-1-carboxylate 2-Methylpiperazine 1,2-Dimethylhydrazine Dihydrochloride 1-Methylpiperazine MK-1775 Niraparib Ponatinib Hydrochloride Galeterone Ponatinib

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