ChemicalBook > CAS DataBase List > 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
- Product Name
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
- CAS No.
- 694499-26-8
- Chemical Name
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
- Synonyms
- PON50;SW-53;SWF-53;AP24592;RMA-315;Ponatinib int2;Ponatinib Impurity 3;Pralsetinib Impurity 1;Intermediate of Ponatinib;4-(4-Methylpiperazinomethyl)-3-
- CBNumber
- CB92520701
- Molecular Formula
- C13H18F3N3
- Formula Weight
- 273.3
- MOL File
- 694499-26-8.mol
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4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Property
- Boiling point:
- 329.1±42.0 °C(Predicted)
- Density
- 1.227
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 7.55±0.10(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- InChI
- InChI=1S/C13H18F3N3/c1-18-4-6-19(7-5-18)9-10-2-3-11(17)8-12(10)13(14,15)16/h2-3,8H,4-7,9,17H2,1H3
- InChIKey
- ZMWAZMYBMAAMAW-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1
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Safety
- HS Code
- 2933599590
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N-Bromosuccinimide Price
TRC
- Product number
- M329373
- Product name
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
- Packaging
- 5g
- Price
- $250
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC51192
- Product name
- 4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $17
- Updated
- 2021/12/16
Oakwood
- Product number
- 212607
- Product name
- 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline
- Purity
- 95%
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H30-3-3G
- Product name
- 4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $28
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC51192
- Product name
- 4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline
- Purity
- 95+%
- Packaging
- 5g
- Price
- $64
- Updated
- 2021/12/16
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4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Chemical Properties,Usage,Production
Uses
4-(6-Acryloyloxyhexyloxy)-benzoesure (4-cyanophenylester) can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and in the process of chemical and pharmaceutical synthesis.
Synthesis
4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline Into a solution 4-methyl-1-(4-nitro-2-(trifluoromethyl)benzyl)piperazine (1.5 g, 5 mmol) in MeOH (250 mL) was added Raney Nickel (0.15 g, 10 wt %). The suspension was stirred under hydrogen atmosphere (50 psi) for 24 hrs and monitored by TLC. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure to yield the desired product (1.36 g, 100%). 1H NMR (300 MHz, CDCl3) |?: 7.43-7.46 (1H, d, J=9.0 Hz), 6.91 (1H, s), 6.77-6.80 (1H, d J=9.0 Hz), 3.77 (2H, s), 3.54 (2H, s), 2.53 (8H, brs), 2.34 (3H, s).
storage
Store long-term at 2-8°C.
References
[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 20, p. 7150 - 7163
[2] Patent: CN105461659, 2016, A. Location in patent: Paragraph 0032; 0033; 0034; 0065; 0066; 0067
[3] Patent: WO2015/186137, 2015, A1. Location in patent: Page/Page column 19
[4] Patent: WO2005/51366, 2005, A2. Location in patent: Page/Page column 62
[5] Patent: WO2005/51366, 2005, A2. Location in patent: Page/Page column 62
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline manufacturers
RongNa Biotechnology Co.,Ltd
- Product
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline 694499-26-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2024-06-25
PNP Biotech Co. Ltd
- Product
- 4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline 694499-26-8
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2022-09-19
Dideu Industries Group Limited
- Product
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline 694499-26-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-05
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