ChemicalBook > CAS DataBase List > 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

Product Name
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
CAS No.
694499-26-8
Chemical Name
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
Synonyms
PON50;SW-53;SWF-53;Ponatinib int2;Ponatinib Impurity 3;Pralsetinib Impurity 1;Intermediate of Ponatinib;4-(4-Methylpiperazinomethyl)-3-;4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline;4-(4-Methylpiperazinomethyl)-4-(trifluoromethyl)aniline
CBNumber
CB92520701
Molecular Formula
C13H18F3N3
Formula Weight
273.3
MOL File
694499-26-8.mol
More
Less

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Property

Boiling point:
329.1±42.0 °C(Predicted)
Density 
1.227
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
7.55±0.10(Predicted)
InChI
InChI=1S/C13H18F3N3/c1-18-4-6-19(7-5-18)9-10-2-3-11(17)8-12(10)13(14,15)16/h2-3,8H,4-7,9,17H2,1H3
InChIKey
ZMWAZMYBMAAMAW-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1
More
Less

Safety

HS Code 
2933599590
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

TRC
Product number
M329373
Product name
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
Packaging
5g
Price
$250
Updated
2021/12/16
Matrix Scientific
Product number
132323
Product name
4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline
Purity
97%
Packaging
25g
Price
$2700
Updated
2021/12/16
Apolloscientific
Product number
PC51192
Product name
4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline
Purity
95+%
Packaging
1g
Price
$17
Updated
2021/12/16
Oakwood
Product number
212607
Product name
4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline
Purity
95%
Packaging
1g
Price
$19
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-3-3G
Product name
4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline
Purity
95.0%
Packaging
1g
Price
$28
Updated
2021/12/16
More
Less

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Chemical Properties,Usage,Production

Uses

4-(6-Acryloyloxyhexyloxy)-benzoesure (4-cyanophenylester) can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and in the process of chemical and pharmaceutical synthesis.

Synthesis


4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline Into a solution 4-methyl-1-(4-nitro-2-(trifluoromethyl)benzyl)piperazine (1.5 g, 5 mmol) in MeOH (250 mL) was added Raney Nickel (0.15 g, 10 wt %). The suspension was stirred under hydrogen atmosphere (50 psi) for 24 hrs and monitored by TLC. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure to yield the desired product (1.36 g, 100%). 1H NMR (300 MHz, CDCl3) |?: 7.43-7.46 (1H, d, J=9.0 Hz), 6.91 (1H, s), 6.77-6.80 (1H, d J=9.0 Hz), 3.77 (2H, s), 3.54 (2H, s), 2.53 (8H, brs), 2.34 (3H, s).

storage

Store long-term at 2-8°C.

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Suppliers

China 216 India 4 United Kingdom 1 United States 9 Global 230
Shandong Mopai Biotechnology Co., Ltd
Tel
13053322091 13053322091
Email
admin@mopaikeji.com
Country
China
ProdList
10974
Advantage
58
JiangYin Ruisheng Chemical Co., Ltd.
Tel
13003356808
Fax
QQ:1485751188
Email
1485751188@qq.com
Country
China
ProdList
403
Advantage
55
Sci General Material & Chemical Ltd
Tel
21-58388037 13472507714
Fax
0086-21-56829747 Company QQ: 1589045147
Email
1589045147@qq.com
Country
China
ProdList
676
Advantage
55
Hunan Huayi Zhide Pharmaceutical Technology Co., Ltd.
Tel
17752881701
Email
190060276@qq.com
Country
China
ProdList
109
Advantage
58
Changzhou Chemscaler Pharmtech Co., Ltd.
Tel
0519-81096292 15312577869
Email
chemscaler@yahoo.com.cn
Country
China
ProdList
307
Advantage
60
Shanghai PharmOrgsyn Technology Co., LTD.
Tel
021-+86-021-38228826
Fax
sales@pharmorgsyn.com
Email
sales@pharmorgsyn.cn
Country
China
ProdList
229
Advantage
58
Shanghai Na Qian Chemical Technology Co. Ltd.
Tel
13598610367
Fax
QQ:2468833170
Email
2841375912@qq.com
Country
China
ProdList
2794
Advantage
52
Haohong (Qihe) Medical Technology Co., LTD
Tel
18068541569 18660163165
Fax
0519-85551569
Email
sale@inyelchem.com
Country
China
ProdList
194
Advantage
58
Shandong Zhonghan Pharmaceutical Co.,Ltd.
Tel
15066662237 15066662237
Email
3281004549@qq.com
Country
China
ProdList
278
Advantage
55
ForeChem (Nantong) Technology Co.,Ltd.
Tel
513-85982855 18921614129
Fax
051385915507
Email
sales@xianxingpharm.com
Country
China
ProdList
1819
Advantage
61
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11660
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
18089
Advantage
64
Shanghai Feibo Chemical Technology Co., Ltd
Tel
021-58955608,2250286 15921236618
Email
blinkzeng@gmail.com
Country
China
ProdList
523
Advantage
62
ChemCell Biomedicine Co.,Ltd.
Tel
020-13556033878 2965585218 13556033878
Fax
0086-0757-85406358
Email
chemcell@hotmail.com
Country
China
ProdList
369
Advantage
52
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
+8613162137806 18575662672
Fax
021 51613951
Email
mzeng@3wpharm.com
Country
China
ProdList
9746
Advantage
57
Heterochem
Tel
027-88041443 13072715837
Fax
027-51829379
Email
sales@hetero-chem.com
Country
China
ProdList
696
Advantage
58
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9900
Advantage
58
Dtchem Laboratories,（Gan Su）Co.,Ltd.
Tel
18993966060
Fax
0943-8288977
Email
sales@techbiochem.com
Country
China
ProdList
937
Advantage
61
Wuhan TCASChem Technology Co., Ltd.
Tel
027-86697669 13986148687
Fax
86-027-86697669
Email
sales@tcaschem.com
Country
China
ProdList
4051
Advantage
55
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1494
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
13901585132
Fax
+86-25-52131256
Email
799750417@qq.com
Country
China
ProdList
8888
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19918
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
18017383231 18017383231
Fax
qq：2817624287
Email
lyh_antaeus@163.com
Country
China
ProdList
9352
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9906
Advantage
55
EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
Email
sales@enlipharma.com
Country
China
ProdList
1874
Advantage
55
Shanghai Huikai Chemical Technology Co., Ltd.
Tel
021-61995394 18916691159
Email
chemicalsea@163.com
Country
China
ProdList
1975
Advantage
58
Nanjing ShengSai Chemical Co., Ltd.
Tel
025-85205967 13951876367
Fax
025-85205967
Email
sales@shengsaichem.com
Country
China
ProdList
670
Advantage
58
Eastbang Pharmaceuticals Technology Co., Ltd.
Tel
+86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387
Fax
+86 (20) 39218032
Country
China
ProdList
454
Advantage
58
Cochemical Ltd.
Tel
029-86115547 17791676824
Fax
02151602123
Email
sales@cochemical.com
Country
China
ProdList
3049
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9636
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10287
Advantage
55
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9798
Advantage
50
Nanjing Duolong Bio-tech Co.,Ltd.
Tel
18905173768
Fax
025-83263139
Email
sales@dolonchem.com
Country
China
ProdList
2297
Advantage
50
Sichuan Argalbio Technology Co,.Ltd
Tel
028-028-60651388 13330964498
Email
slyu@hengkangtech.com
Country
China
ProdList
379
Advantage
58
Nanjing Chempioneer Pharmaceutical Co., Ltd.
Tel
18068075658
Fax
-
Email
sales@chempioneer.com
Country
China
ProdList
1811
Advantage
58
Wuhan Kai Lun new material Chemical Co Ltd
Tel
025-87787262
Fax
025-87787262
Country
China
ProdList
496
Advantage
58
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6508
Advantage
58
ShangHai Wisacheam Pharmaceutical Co., Ltd.
Tel
13817485796
Fax
QQ:895624079
Email
tim@wisacheampharm.com
Country
China
ProdList
3710
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9254
Advantage
55
Suzhou Crst Pharmatech Co., Ltd.
Tel
0512-62910395 17751098781
Fax
0512-62910396
Email
sales@crstpharma.com
Country
China
ProdList
499
Advantage
58
Hangzhou Copiore Chemical Co., Ltd.
Tel
0571-56076030 13757145729
Fax
0571-56076030
Email
sales@copiore.com
Country
China
ProdList
233
Advantage
58
Suzhou TaCheng Pharmaceutical Co., Ltd.
Tel
0512-68253519 18260240186
Fax
0512-68253519
Email
122141838@qq.com
Country
China
ProdList
76
Advantage
55
Fuyang JSK Biomedical Technology Co., Ltd
Tel
18915409046
Fax
0510-86566870
Email
1102409417@qq.com
Country
China
ProdList
272
Advantage
55
BTC Pharmaceutical CO. Ltd
Tel
0513-0513-68015-397-397 15716293042
Fax
0513-68015394
Email
sales14@btcpharm.com
Country
China
ProdList
654
Advantage
55
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9934
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9604
Advantage
55
More
Less

View Lastest Price from 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline manufacturers

PNP Biotech Co. Ltd
Product
4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline 694499-26-8
Price
US $0.00/KG
Min. Order
25KG
Purity
98%
Supply Ability
Inquiry
Release date
2022-09-19
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline 694499-26-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
Dideu Industries Group Limited
Product
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline 694499-26-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-05

694499-26-8, 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)anilineRelated Search:

1-Methyl-4-[[4-nitro-2-(trifluoromethyl)phenyl]methyl]-piperazine 1-(bromomethyl)-4-nitro-2-(trifluoromethyl)benzene 5-BROMO-2-METHYL-3-NITROPHENYL METHYLCARBOXYLATE 2,4-dichloro-7H-Pyrrolo[2,3-d]pyriMidine-7-carboxylic acid 1,1-diMethylethyl ester 1-METHYL-5-NITRO-1H-INDAZOLE 5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE rac-4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl No Chinese name (6-Methylpyridazin-3-yl)MethanaMine dihydrochloride tert-butyl 4-(4-broMothiazol-2-yl)piperazine-1-carboxylate 2-Methylpiperazine 1,2-Dimethylhydrazine Dihydrochloride 1-Methylpiperazine MK-1775 Niraparib Ponatinib Hydrochloride Galeterone Ponatinib

  • 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
  • 4-((4-Methylpiperazin-1-yl)methyl)-3-trifluoromethylphenylamine
  • 4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline
  • 4-[(4-Methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzenamine
  • BenzenaMine, 4-[(4-Methyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)-
  • 4-[(4-Methyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)aniline
  • 4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline 95+%
  • 5-Amino-2-[(4-methylpiperazin-1-yl)methyl]benzotrifluoride, 1-[4-Amino-2-(trifluoromethyl)benzyl]-4-methylpiperazine
  • 4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline 4-((4-Methylpiperazin-1-yl)methyl)-3-trifluoromethylphenylamine
  • Ponatinib Impurity 3
  • Ponatinib int2
  • 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline IN Stock
  • 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline IN Stock COA TDS free sample
  • 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline TDS msds coa
  • PON50
  • 4-(4-METHYLPIPERAZINOMETHYL)-3-(TRIFLUOROMETHYL)ANILINE 694499-26-8
  • 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline USP/EP/BP
  • SWF-53
  • SW-53
  • Benzenamine, 4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoro...
  • 3-(trifluoromethyl)-4-((4-methylpiperazin-1-yl)methyl)benzenamine
  • 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline-d8
  • 4-(4-Methylpiperazinomethyl)-4-(trifluoromethyl)aniline
  • 1-[4-Amino-2-(Trifluoromethyl)benzyl]-4-MethylPiperazine
  • 4-(4-Methylpiperazinomethyl)-3-
  • Pralsetinib Impurity 1
  • Intermediate of Ponatinib
  • 694499-26-8