ChemicalBook > CAS DataBase List > 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid

4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid

Product Name
4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid
CAS No.
104561-41-3
Chemical Name
4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid
Synonyms
EC 23;BASF-46928;EC23, 10 mM in DMSO;OQVLOWLEEHYBJH-UHFFFAOYSA-N;EC-23, photostable synthetic retinoid;Inhibitor,EC-23,BASF 46928,EC23,EC 23,AGN-190205,BASF46928,AGN190205,inhibit;4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethynyl)benzoic acid;4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid;Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl]-
CBNumber
CB82518772
Molecular Formula
C23H24O2
Formula Weight
332.44
MOL File
104561-41-3.mol
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4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid Property

Melting point:
254-256 °C(Solv: acetonitrile (75-05-8))
Boiling point:
484.7±45.0 °C(Predicted)
Density 
1.15±0.1 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml
form 
White to off-white lyophilised amorphous solid.
pka
4.10±0.10(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2404
Product name
EC23
Purity
≥98% (HPLC)
Packaging
5MG
Price
$69
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2404
Product name
EC23
Purity
≥98% (HPLC)
Packaging
25MG
Price
$279
Updated
2024/03/01
Cayman Chemical
Product number
9002073
Product name
EC 23
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
9002073
Product name
EC 23
Purity
≥98%
Packaging
5mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
9002073
Product name
EC 23
Purity
≥98%
Packaging
10mg
Price
$117
Updated
2024/03/01
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4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid Chemical Properties,Usage,Production

Uses

EC 23 is an ATRA analog with similar activity. EC 23 potently induces neural differentiation in human pluripotent embryonic stem cells.

Biological Activity

EC23 is a synthetic, photostable all-trans retinoic acid (ATRA) analog/mimetic th at targets RAR with greater affinity than ATRA (RARα/β/γ EC50 by cell-free TR-FRET binding assay = 3.7/3.3/16.8 with EC23 vs. 16.0/17.6/14.7 nM with ATRA) and does not bind retinoid x receptors (RXRs). EC23 induces differentiation of human pluripotent embryonic stem cells (0.1-10 μM) with a similar or better efficiency than ATRA.

storage

+4°C

4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid Suppliers

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104561-41-3, 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacidRelated Search:

4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID Acitretin Adapalene Isotretinoin 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Retinoic acid 4-HYDROXYPHENYLRETINAMIDE TTNPB (Arotinoid Acid) METHOPRENE Ro 41-5253

  • 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid
  • EC 23
  • OQVLOWLEEHYBJH-UHFFFAOYSA-N
  • BASF-46928
  • Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl]-
  • Inhibitor,EC-23,BASF 46928,EC23,EC 23,AGN-190205,BASF46928,AGN190205,inhibit
  • 4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethynyl)benzoic acid
  • EC-23, photostable synthetic retinoid
  • EC23, 10 mM in DMSO
  • 104561-41-3