Ro 41-5253
- Product Name
- Ro 41-5253
- CAS No.
- 144092-31-9
- Chemical Name
- Ro 41-5253
- Synonyms
- Ro 41-5253;Ro 41-5253 >=98% (HPLC);4-[2-(7-Heptoxy-4,4-dimethyl-1,1-dioxo-2,3-dihydrothiochromen-6-yl)<W;4-(2-(7-(Heptyloxy)-3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)-1-propenyl)-Benzoic acid, S,S-dioxide;4-[(1E)-2-[7-(Heptyloxy)-3,4-dihydro-4,4-dimethyl-1,1-dioxido-2H-1-benzothiopyran-6-yl]-1-propen-1-yl]-benzoic acid;Benzoic acid, 4-[(1E)-2-[7-(heptyloxy)-3,4-dihydro-4,4-dimethyl-1,1-dioxido-2H-1-benzothiopyran-6-yl]-1-propen-1-yl]-
- CBNumber
- CB01329632
- Molecular Formula
- C28H36O5S
- Formula Weight
- 484.65
- MOL File
- 144092-31-9.mol
Ro 41-5253 Property
- storage temp.
- -20°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0573
- Product name
- Ro 41-5253
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $64.4
- Updated
- 2024/03/01
- Product number
- SML0573
- Product name
- Ro 41-5253
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $620
- Updated
- 2024/03/01
- Product number
- INB0004027
- Product name
- (E)-S,S-DIOXIDE-4-(2-(7-(HEPTYLOXY)-3,4-DIHYDRO-4,4-DIMETHYL-2H-1-BENZOTHIOPYRAN-6-YL)-1-PROPENYL)BENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $223.3
- Updated
- 2021/12/16
Ro 41-5253 Chemical Properties,Usage,Production
Description
Ro 41-5253 (144092-31-9) is a selective RARα antagonist.1?Binds RARα without inducing transcription or influencing RAR/RXR heterodimerization and DNA binding.2?Ro 415253 inhibits proliferation and induces apoptosis in a variety of cell lines/types. Cell Permeable.
Uses
Ro 415253 is a retinoic acid receptor antagonists, a promising starting point for antimetastatic therapies.
Definition
ChEBI: A thiochromane that is 3,4-dihydro-2H-1-benzothiopyran S,S-dioxide in which the hydrogens at position 4 are both replaced by methyl groups, the hydrogens at position 7 is replaced by a heptyloxy group, w ile the hydrogen at position 6 is replaced by a 1-phenylprop-1-en-2-yl group, the phenyl group of which is substituted at the para position by a carboxy group. It is a selective antagonist for retinoic acid receptor alpha.
References
1) Apfel?et al. (1992),?A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects; Proc. Natl. Acad. Sci. USA,?89?7129 2) Toma?et al. (1998),?RARα antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines; Int. J. Cancer,?78?86
Ro 41-5253 Preparation Products And Raw materials
Raw materials
Preparation Products
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