Ro 41-5253

Product Name: Ro 41-5253
CAS No.: 144092-31-9
Chemical Name: Ro 41-5253
Synonyms: Ro 41-5253;Ro 41-5253 >=98% (HPLC);4-[2-(7-Heptoxy-4,4-dimethyl-1,1-dioxo-2,3-dihydrothiochromen-6-yl)
CBNumber: CB01329632
Molecular Formula: C28H36O5S
Formula Weight: 484.65
MOL File: 144092-31-9.mol

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Ro 41-5253 Property

storage temp.: -20°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0573
Product name: Ro 41-5253
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $157.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0573
Product name: Ro 41-5253
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $637
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: INB0004027
Product name: (E)-S,S-DIOXIDE-4-(2-(7-(HEPTYLOXY)-3,4-DIHYDRO-4,4-DIMETHYL-2H-1-BENZOTHIOPYRAN-6-YL)-1-PROPENYL)BENZOIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $223.3
Updated: 2021/12/16

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Ro 41-5253 Chemical Properties,Usage,Production

Description

Ro 41-5253 (144092-31-9) is a selective RARα antagonist.1?Binds RARα without inducing transcription or influencing RAR/RXR heterodimerization and DNA binding.2?Ro 415253 inhibits proliferation and induces apoptosis in a variety of cell lines/types. Cell Permeable.

Uses

Ro 415253 is a retinoic acid receptor antagonists, a promising starting point for antimetastatic therapies.

Definition

ChEBI: A thiochromane that is 3,4-dihydro-2H-1-benzothiopyran S,S-dioxide in which the hydrogens at position 4 are both replaced by methyl groups, the hydrogens at position 7 is replaced by a heptyloxy group, w ile the hydrogen at position 6 is replaced by a 1-phenylprop-1-en-2-yl group, the phenyl group of which is substituted at the para position by a carboxy group. It is a selective antagonist for retinoic acid receptor alpha.

in vivo

Ro 41-5253 (oral gavage, 10-600 mg/kg, once a week, 4 weeks) can reduce tumor volume in female athymic Balb/mice transplanted with MCF-7 cell line^[2].

Animal Model:	Six-week-old female athymic Balb/mice transplanted with MCF-7 cell line^[2]
Dosage:	10, 30, 100, 300 and 600 mg/kg
Administration:	Oral gavage; once a week; 4 weeks
Result:	Resulted in a reduction in tumor volume at doses of 10, 30 and 100 mg/kg with no toxic side effects.

References

[1] C APFEL. A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1992, 89 15: 7129-7133. DOI:10.1073/pnas.89.15.7129
[2] SALVATORE TOMA. RARα antagonist RO 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines[J]. International Journal of Cancer, 1999, 78 1: 86-94. DOI:10.1002/(sici)1097-0215(19980925)78:1<86::aid-ijc14>3.0.co;2-3

Ro 41-5253 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ro 41-5253 Suppliers

China 32 United States 5 Global 37

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Jiangsu aikang biomedical research and development co., LTD

Tel: 025-58859352 13155353615
Email: qzhang@aikonchem.com
Country: China
ProdList: 15525
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5929
Advantage: 58

Foshan Heshuo Pharm technology Co., ltd

Tel: 15363639686
Email: heshuoyiyao@hotmail.com
Country: China
ProdList: 2376
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Enzo Biochem Inc

Tel: Enzo Biochem Inc. 13797054060
Email: Enzoname@qq.com
Country: China
ProdList: 6174
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

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Ro 41-5253

4-(2-(7-(Heptyloxy)-3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)-1-propenyl)-Benzoic acid, S,S-dioxide

4-[(1E)-2-[7-(Heptyloxy)-3,4-dihydro-4,4-dimethyl-1,1-dioxido-2H-1-benzothiopyran-6-yl]-1-propen-1-yl]-benzoic acid

4-[2-(7-Heptoxy-4,4-dimethyl-1,1-dioxo-2,3-dihydrothiochromen-6-yl)<W

Benzoic acid, 4-[(1E)-2-[7-(heptyloxy)-3,4-dihydro-4,4-dimethyl-1,1-dioxido-2H-1-benzothiopyran-6-yl]-1-propen-1-yl]-

Ro 41-5253 >=98% (HPLC)

144092-31-9