ChemicalBook > CAS DataBase List > Ro 41-5253

Ro 41-5253

Product Name
Ro 41-5253
CAS No.
144092-31-9
Chemical Name
Ro 41-5253
Synonyms
Ro 41-5253;Ro 41-5253 >=98% (HPLC);4-[2-(7-Heptoxy-4,4-dimethyl-1,1-dioxo-2,3-dihydrothiochromen-6-yl)<W;4-(2-(7-(Heptyloxy)-3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)-1-propenyl)-Benzoic acid, S,S-dioxide;4-[(1E)-2-[7-(Heptyloxy)-3,4-dihydro-4,4-dimethyl-1,1-dioxido-2H-1-benzothiopyran-6-yl]-1-propen-1-yl]-benzoic acid;Benzoic acid, 4-[(1E)-2-[7-(heptyloxy)-3,4-dihydro-4,4-dimethyl-1,1-dioxido-2H-1-benzothiopyran-6-yl]-1-propen-1-yl]-
CBNumber
CB01329632
Molecular Formula
C28H36O5S
Formula Weight
484.65
MOL File
144092-31-9.mol
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Ro 41-5253 Property

storage temp. 
-20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0573
Product name
Ro 41-5253
Purity
≥98% (HPLC)
Packaging
5mg
Price
$64.4
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0573
Product name
Ro 41-5253
Purity
≥98% (HPLC)
Packaging
25mg
Price
$620
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
INB0004027
Product name
(E)-S,S-DIOXIDE-4-(2-(7-(HEPTYLOXY)-3,4-DIHYDRO-4,4-DIMETHYL-2H-1-BENZOTHIOPYRAN-6-YL)-1-PROPENYL)BENZOIC ACID
Purity
95.00%
Packaging
5MG
Price
$223.3
Updated
2021/12/16
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Ro 41-5253 Chemical Properties,Usage,Production

Description

Ro 41-5253 (144092-31-9) is a selective RARα antagonist.1?Binds RARα without inducing transcription or influencing RAR/RXR heterodimerization and DNA binding.2?Ro 415253 inhibits proliferation and induces apoptosis in a variety of cell lines/types. Cell Permeable.

Uses

Ro 415253 is a retinoic acid receptor antagonists, a promising starting point for antimetastatic therapies.

Definition

ChEBI: A thiochromane that is 3,4-dihydro-2H-1-benzothiopyran S,S-dioxide in which the hydrogens at position 4 are both replaced by methyl groups, the hydrogens at position 7 is replaced by a heptyloxy group, w ile the hydrogen at position 6 is replaced by a 1-phenylprop-1-en-2-yl group, the phenyl group of which is substituted at the para position by a carboxy group. It is a selective antagonist for retinoic acid receptor alpha.

References

1) Apfel?et al. (1992),?A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects; Proc. Natl. Acad. Sci. USA,?89?7129 2) Toma?et al. (1998),?RARα antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines; Int. J. Cancer,?78?86

Ro 41-5253 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ro 41-5253 Suppliers

China 26 United States 5 Global 31
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Jiangsu aikang biomedical research and development co., LTD
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025-66110311 13155353615
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qzhang@aikonchem.com
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Energy Chemical
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marketing1@energy-chemical.com
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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Nantong QuanYi Biotechnology Co., Ltd
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0513-66337626 18051384581
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sales@chemhifuture.com
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Shanghai Haoran Biotechnology Co., Ltd.
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Shanghai Yuqi Biological Technology Co., Ltd.
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Shanghai Hao Biological Technology Co., Ltd.
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shxiyuanbio@163.com
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Boao Pike
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Beijing Lebo Biotechnology Co., Ltd.
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Shenzhen Xinbosheng Biological Technology Co., Ltd.
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  • Ro 41-5253
  • 4-(2-(7-(Heptyloxy)-3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)-1-propenyl)-Benzoic acid, S,S-dioxide
  • 4-[(1E)-2-[7-(Heptyloxy)-3,4-dihydro-4,4-dimethyl-1,1-dioxido-2H-1-benzothiopyran-6-yl]-1-propen-1-yl]-benzoic acid
  • 4-[2-(7-Heptoxy-4,4-dimethyl-1,1-dioxo-2,3-dihydrothiochromen-6-yl)<W
  • Benzoic acid, 4-[(1E)-2-[7-(heptyloxy)-3,4-dihydro-4,4-dimethyl-1,1-dioxido-2H-1-benzothiopyran-6-yl]-1-propen-1-yl]-
  • Ro 41-5253 >=98% (HPLC)
  • 144092-31-9