4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid

Product Name: 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid
CAS No.: 104561-41-3
Chemical Name: 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid
Synonyms: EC 23;BASF-46928;EC23, 10 mM in DMSO;OQVLOWLEEHYBJH-UHFFFAOYSA-N;EC-23, photostable synthetic retinoid;Inhibitor,EC-23,BASF 46928,EC23,EC 23,AGN-190205,BASF46928,AGN190205,inhibit;4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethynyl)benzoic acid;4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid;Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl]-
CBNumber: CB82518772
Molecular Formula: C23H24O2
Formula Weight: 332.44
MOL File: 104561-41-3.mol

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4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid Property

Melting point:: 254-256 °C(Solv: acetonitrile (75-05-8))
Boiling point:: 484.7±45.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml
form: White to off-white lyophilised amorphous solid.
pka: 4.10±0.10(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2404
Product name: EC23
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $69
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2404
Product name: EC23
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $279
Updated: 2024/03/01

Cayman Chemical

Product number: 9002073
Product name: EC 23
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 9002073
Product name: EC 23
Purity: ≥98%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 9002073
Product name: EC 23
Purity: ≥98%
Packaging: 10mg
Price: $117
Updated: 2024/03/01

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4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid Chemical Properties,Usage,Production

Uses

EC 23 is an ATRA analog with similar activity. EC 23 potently induces neural differentiation in human pluripotent embryonic stem cells.

Biological Activity

EC23 is a synthetic, photostable all-trans retinoic acid (ATRA) analog/mimetic th at targets RAR with greater affinity than ATRA (RARα/β/γ EC50 by cell-free TR-FRET binding assay = 3.7/3.3/16.8 with EC23 vs. 16.0/17.6/14.7 nM with ATRA) and does not bind retinoid x receptors (RXRs). EC23 induces differentiation of human pluripotent embryonic stem cells (0.1-10 μM) with a similar or better efficiency than ATRA.

storage

+4°C

4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid Suppliers

China 65 India 1 United Kingdom 1 United States 8 Global 75

3B Pharmachem (Wuhan) International Co.,Ltd.

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TargetMol Chemicals Inc.

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104561-41-3, 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacidRelated Search:

4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID Acitretin Adapalene Isotretinoin 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Retinoic acid 4-HYDROXYPHENYLRETINAMIDE TTNPB (Arotinoid Acid) METHOPRENE Ro 41-5253

4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid

EC 23

OQVLOWLEEHYBJH-UHFFFAOYSA-N

BASF-46928

Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl]-

Inhibitor,EC-23,BASF 46928,EC23,EC 23,AGN-190205,BASF46928,AGN190205,inhibit

4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethynyl)benzoic acid

EC-23, photostable synthetic retinoid

EC23, 10 mM in DMSO

104561-41-3