N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

Product Name: N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
CAS No.: 53501-41-0
Chemical Name: N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
Synonyms: PIT 1;PIT-1, PIP3/protein binding inhibitor;N-((3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl)benzamide;N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide;Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-
CBNumber: CB82518929
Molecular Formula: C14H10ClN3O4S
Formula Weight: 351.76
MOL File: 53501-41-0.mol

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N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Property

Density: 1.592
storage temp.: Store at +4°C
solubility: DMSO: ≥14mg/mL
form: powder
pka: 4.44±0.50(Predicted)
color: white to tan
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0122
Product name: Pit-1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $101
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0122
Product name: Pit-1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $399
Updated: 2025/07/31

Cayman Chemical

Product number: 10728
Product name: PIT-1
Purity: ≥98%
Packaging: 5mg
Price: $20
Updated: 2024/03/01

Cayman Chemical

Product number: 10728
Product name: PIT-1
Purity: ≥98%
Packaging: 10mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 10728
Product name: PIT-1
Purity: ≥98%
Packaging: 50mg
Price: $146
Updated: 2024/03/01

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N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Chemical Properties,Usage,Production

Description

PtdIns-(3,4,5)-P₃ (PIP₃) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP₃ is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. PIT-1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP₃/Akt PH domain binding with an IC₅₀ value of 31 μM. PIT-1 suppresses PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC₅₀ = 37 μM).

Uses

PIT 1 is an apoptosis inducing selective PIP3 antagonist.

References

[1] BENCHUN MIAO. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2010: 20126-20131. DOI:10.1073/pnas.1004522107
[2] COLLEEN R MCNAMARA A D. Small-molecule inhibitors of the PI3K signaling network.[J]. Future medicinal chemistry, 2011, 3 5: 549-565. DOI:10.4155/fmc.11.12

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Suppliers

China 58 United Kingdom 2 United States 11 Global 71

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53501-41-0, N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamideRelated Search:

TYRPHOSTIN AG 1296 ZM 336372 LFM-A13 SU 4312

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

PIT 1

Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-

N-((3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl)benzamide

PIT-1, PIP3/protein binding inhibitor

53501-41-0

C14H10ClN3O4S