ChemicalBook > CAS DataBase List > N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

Product Name
N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
CAS No.
53501-41-0
Chemical Name
N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
Synonyms
PIT 1;PIT-1, PIP3/protein binding inhibitor;N-((3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl)benzamide;N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide;Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-
CBNumber
CB82518929
Molecular Formula
C14H10ClN3O4S
Formula Weight
351.76
MOL File
53501-41-0.mol
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N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Property

Density 
1.592
storage temp. 
Store at +4°C
solubility 
DMSO: ≥14mg/mL
form 
powder
pka
4.44±0.50(Predicted)
color 
white to tan
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0122
Product name
Pit-1
Purity
≥98% (HPLC)
Packaging
5mg
Price
$97.9
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0122
Product name
Pit-1
Purity
≥98% (HPLC)
Packaging
25mg
Price
$388
Updated
2024/03/01
Cayman Chemical
Product number
10728
Product name
PIT-1
Purity
≥98%
Packaging
5mg
Price
$20
Updated
2024/03/01
Cayman Chemical
Product number
10728
Product name
PIT-1
Purity
≥98%
Packaging
10mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
10728
Product name
PIT-1
Purity
≥98%
Packaging
50mg
Price
$146
Updated
2024/03/01
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N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Chemical Properties,Usage,Production

Description

PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. PIT-1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP3/Akt PH domain binding with an IC50 value of 31 μM. PIT-1 suppresses PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM).

Uses

PIT 1 is an apoptosis inducing selective PIP3 antagonist.

References

1) Maio?et al.?(2010),?Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PI3) binding to pleckstrin homology domains; Proc. Natl. Acad. Sci. USA,?107?20126 2) McNamare and Degterev?(2011),?Small-molecule inhibitor of the PI3K signaling network; Future Med. Chem.,?3?549

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Suppliers

China 46 United Kingdom 2 United States 11 Global 59
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
Glentham Life Sciences
Tel
--
Fax
--
Email
info@glenthamls.com
Country
United Kingdom
ProdList
1429
Advantage
0

53501-41-0, N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamideRelated Search:

TYRPHOSTIN AG 1296 ZM 336372 LFM-A13 SU 4312

  • N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
  • PIT 1
  • Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-
  • N-((3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl)benzamide
  • PIT-1, PIP3/protein binding inhibitor
  • 53501-41-0
  • C14H10ClN3O4S