PTEROIC ACID
- Product Name
- PTEROIC ACID
- CAS No.
- 119-24-4
- Chemical Name
- PTEROIC ACID
- Synonyms
- 4-(((2-AMino-4-oxo-3,4-dihydropteridin-6-yl)Methyl)aMino)benzoic acid;Pyrofolic acid;4-[(2-amino-4-keto-1H-pteridin-6-yl)methylamino]benzoic acid;NSC 14972;PTEROIC ACID;Butterfly acid;Pteroic Acid (>Pteroic acid >=93%;Pteroic Acid (>85%);Folic acid iMpurity D
- CBNumber
- CB8254618
- Molecular Formula
- C14H12N6O3
- Formula Weight
- 312.28
- MOL File
- 119-24-4.mol
PTEROIC ACID Property
- Melting point:
- >400℃
- Boiling point:
- 610.0±65.0 °C(Predicted)
- Density
- 1.69
- storage temp.
- 2-8°C
- solubility
- Aqueous Base (Slightly), DMSO (Slightly)
- pka
- 4.65±0.10(Predicted)
- color
- Light Yellow to Brown
Safety
- WGK Germany
- 3
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- P1781
- Product name
- Pteroic acid
- Purity
- ≥93%
- Packaging
- 25mg
- Price
- $81.7
- Updated
- 2024/03/01
- Product number
- P1781
- Product name
- Pteroic acid
- Purity
- ≥93%
- Packaging
- 50mg
- Price
- $131
- Updated
- 2024/03/01
- Product number
- PHR2002
- Product name
- Folic Acid Impurity D
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 100mg
- Price
- $647
- Updated
- 2024/03/01
- Product number
- Y0001243
- Product name
- Folic acid impurity D
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001243
- Price
- $220
- Updated
- 2024/03/01
- Product number
- P1781
- Product name
- Pteroic acid
- Purity
- ≥93%
- Packaging
- 100mg
- Price
- $255
- Updated
- 2024/03/01
PTEROIC ACID Chemical Properties,Usage,Production
Uses
Pteroic Acid is a constituent as well as a degradation product of Folid Acid (F680300) formed via anzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutama te synthetase.
Uses
Pteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase.
Definition
ChEBI: 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid is a pteroic acid. It is functionally related to a 2-aminopteridin-4-ol. It is a conjugate base of a 2-amino-6-{[(4-carboxyphenyl)amino]methyl}-4-hydroxypteridin-1-ium. It is a conjugate acid of a 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoate. It is a tautomer of a 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoic acid and a 4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoic acid.
General Description
Folic Acid Impurity D is an impurity of the water-soluble B-vitamin, folic acid. Folic Acid is generally used in the treatment of certain types of anemia.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Enzyme inhibitor
This metabolite (FWfree-acid = 312.29 g/mol; CAS 119-24-4), also known as 4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic acid, is a structural component of folates. Pteroic acid is a growth factor for a number of Enterococci. Pteroic acid is a yellow powder that is slightly soluble in aqueous NaOH. The lmax values in 0.1 M NaOH are 255, 275, and 365 nm (e = 26300, 23400, and 8900 M–1cm–1, respectively). Target(s): arylamine N-acetyltransferase; dihydrofolate reductase; dihydrofolate synthetase, weakly inhibited; dihydropteroate synthase; glutamate carboxypeptidase; and xanthine oxidase.
Purification Methods
Crystallise it from dilute HCl. Dry it in vacuo. Hygroscopic IRRITANT. [Nair et al. J Org Chem 46 3152 1981, Beilstein 26 III/IV 3942.]
PTEROIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PTEROIC ACID manufacturers
- Product
- Pteroic Acid 119-24-4
- Price
- US $10.00/g/Bag
- Min. Order
- 10g
- Purity
- 99
- Supply Ability
- 100KG
- Release date
- 2021-11-16
- Product
- Pteroic Acid 119-24-4
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000t
- Release date
- 2021-05-07
- Product
- PTEROIC ACID 119-24-4
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-15