H2N-PEG2-Propyne
- Product Name
- H2N-PEG2-Propyne
- CAS No.
- 944561-44-8
- Chemical Name
- H2N-PEG2-Propyne
- Synonyms
- Propargyl-PEG2-NH2;2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine;HC≡C-CH2-PEG2-NH2;2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine hydrochloride;NH2-PEG2-Al;Alkyne-PEG2-NH2;H2N-PEG2-Propyne;Alkyne-PEG2-amine;Propyne-PEG2-amine;NH2-PEG2-Propargyl
- CBNumber
- CB82546863
- Molecular Formula
- C7H13NO2
- Formula Weight
- 143.18
- MOL File
- 944561-44-8.mol
H2N-PEG2-Propyne Property
- Boiling point:
- 213.8±20.0 °C(Predicted)
- Density
- 0.992±0.06 g/cm3(Predicted)
- refractive index
- 1.4590 to 1.4630
- Flash point:
- 88°
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO:100.0(Max Conc. mg/mL);698.37(Max Conc. mM)
- form
- clear liquid
- pka
- 8.72±0.10(Predicted)
- color
- Colorless to Almost colorless
- Appearance
- colorless to yellow liquid
Safety
- RIDADR
- UN 2735 8/PG II
- HS Code
- 2922.19.9690
- HazardClass
- 8
- PackingGroup
- II
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P2225
- Product name
- 2-[2-(2-Propynyloxy)ethoxy]ethylamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $96
- Updated
- 2025/07/31
- Product number
- P2225
- Product name
- 2-[2-(2-Propynyloxy)ethoxy]ethylamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $348
- Updated
- 2025/07/31
- Product number
- BP-22519
- Product name
- Propargyl-PEG2-amine
- Purity
- 98%
- Packaging
- 1g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- CS-0044012
- Product name
- Propargyl-PEG2-amine
- Purity
- 96.52%
- Packaging
- 10g
- Price
- $373
- Updated
- 2021/12/16
- Product number
- P000486784
- Product name
- 2-[2-(2-Propynyloxy)ethoxy]ethylamine
- Purity
- 97%
- Packaging
- 10g
- Price
- $379
- Updated
- 2021/12/16
H2N-PEG2-Propyne Chemical Properties,Usage,Production
Description
Propargyl-PEG2-amine is a crosslinker that is reactive with NHS esters, carbonyls (carboxylic acid, ketone, aldehyde). The propargyl group can participate in copper catalyzed azide-alkyne Click Chemistry reaction to form a stable triazole linkage.
Uses
2-[2-(2-Propynyloxy)ethoxy]ethylamine is used in preparation of RSV F protein inhibitors conjugated to Fc variants and albumins.
Synthesis
1245006-63-6
944561-44-8
The general procedure for the synthesis of 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethylamine from the compound (CAS:1245006-63-6) is as follows: General method: polymer-loaded triphenylphosphine (1.15 eq.) was added to an anhydrous tetrahydrofuran (THF) solution of azide alkynes S3. Subsequently, the reaction mixture was stirred at room temperature for 48 hours. Next, deionized water (1 mL) was added to the flask and the resulting mixture was continued to be stirred at room temperature for 48 hours. Upon completion of the reaction, the mixture was filtered through a bed of diatomaceous earth to collect insoluble solids and washed with ethyl acetate (25 mL). Finally, the combined filtrates were concentrated under reduced pressure to give the target product aminoalkynes 6.
IC 50
Non-cleavable Linker; PEGs
References
[1] Molecules, 2013, vol. 18, # 9, p. 11639 - 11657
[2] Journal of the American Chemical Society, 2010, vol. 132, # 36, p. 12711 - 12716
[3] Drug Design, Development and Therapy, 2018, vol. 12, p. 987 - 995
[4] Journal of Porphyrins and Phthalocyanines, 2013, vol. 17, # 1-2, p. 104 - 117
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View Lastest Price from H2N-PEG2-Propyne manufacturers
- Product
- Propargyl-PEG2-amine 944561-44-8
- Price
- US $0.00/g
- Min. Order
- 25g
- Purity
- >98.00%
- Supply Ability
- 25g
- Release date
- 2024-03-26
- Product
- H2N-PEG2-Propyne 944561-44-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09