5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE

Product Name: 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
CAS No.: 218457-67-1
Chemical Name: 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
Synonyms: Limantrafin;BUTTPARK 96\12-100;6-(4-tert-butylphenoxy)-3-pyridinamine;5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE;6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine97%;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97%;6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine;3-Pyridinamine, 6-[4-(1,1-dimethylethyl)phenoxy]-;pathway,CB103,inhibit,Inhibitor,Notch,CB-103,signaling,leukemia,CB 103
CBNumber: CB8254830
Molecular Formula: C15H18N2O
Formula Weight: 242.32
MOL File: 218457-67-1.mol

More

Less

5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Property

Melting point:: 89-90
storage temp.: 2-8°C
solubility: Soluble in DMSO (>30 mg/ml)
form: solid
color: Off-white to pale orange
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 218457-67-1(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3460
Product name: CB-103
Purity: ≥97% (HPLC)
Packaging: 10MG
Price: $64.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3460
Product name: CB-103
Purity: ≥97% (HPLC)
Packaging: 50MG
Price: $261
Updated: 2024/03/01

TRC

Product number: A594853
Product name: 5-Amino-2-(4-tert-butylphenoxy)pyridine
Packaging: 500mg
Price: $90
Updated: 2021/12/16

TRC

Product number: A594853
Product name: 5-Amino-2-(4-tert-butylphenoxy)pyridine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR8051
Product name: 6-[4-(tert-Butyl)phenoxy]pyridin-3-amine
Purity: 97%
Packaging: 1g
Price: $105
Updated: 2021/12/16

More

Less

5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Chemical Properties,Usage,Production

Description

CB-103 (218457-67-1) is an orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 μM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines.? CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors.

References

Lehal et al. (2020), Pharmacological disruption of the Notch transcription factor complex; Proc. Natl. Acad. Sci. USA, 117 16292

5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Suppliers

China 62 Germany 2 India 1 Ukraine 1 United Kingdom 6 United States 17 Global 89

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

Leancare Ltd.

Tel: --
Fax: --
Email: enquiry@leancare.co.uk
Country: United Kingdom
ProdList: 6446
Advantage: 42

CARBONE SCIENTIFIC CO.,LTD

Tel: --
Fax: --
Email: sales@carbonesci.com
Country: United Kingdom
ProdList: 6666
Advantage: 30

ETA SCIENTIFIC Co.,Ltd

Tel: --
Fax: --
Email: sales@etascientific.com
Country: United Kingdom
ProdList: 6090
Advantage: 34

UK GREEN SCIENTIFIC CO.,LIMITED

Tel: --
Fax: --
Email: sales@gs-chem.com
Country: United Kingdom
ProdList: 6098
Advantage: 47

Butt Park Ltd.

Tel: --
Fax: --
Email: 113707.50@compuserve.com
Country: United Kingdom
ProdList: 6078
Advantage: 30

218457-67-1, 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINERelated Search:

PF-01367338 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide METHOPRENE ACID Acalabrutinib 1-Bromo-4-tert-butylbenzene 4-t-Butylbenzamide 3-Amino-6-hydroxypyridine 2-methoxy-5-aminopyridine 6-PHENOXY-3-PYRIDINAMINE 2-PHENOXYPYRIDINE 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE

6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97%

6-[4-(tert-Butyl)phenoxy]pyridin-3-amine97%

5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE

6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE

BUTTPARK 96\12-100

6-(4-tert-butylphenoxy)-3-pyridinamine

3-Pyridinamine, 6-[4-(1,1-dimethylethyl)phenoxy]-

pathway,CB103,inhibit,Inhibitor,Notch,CB-103,signaling,leukemia,CB 103

6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine

Limantrafin

218457-67-1

C15H18N2O

ARYL AMINE