5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE

Product Name: 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
CAS No.: 218457-67-1
Chemical Name: 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
Synonyms: Limantrafin;BUTTPARK 96\12-100;6-(4-tert-butylphenoxy)-3-pyridinamine;5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE;6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine97%;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97%;6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine;3-Pyridinamine, 6-[4-(1,1-dimethylethyl)phenoxy]-;pathway,CB103,inhibit,Inhibitor,Notch,CB-103,signaling,leukemia,CB 103
CBNumber: CB8254830
Molecular Formula: C15H18N2O
Formula Weight: 242.32
MOL File: 218457-67-1.mol

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5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Property

Melting point:: 89-90
storage temp.: 2-8°C
solubility: Soluble in DMSO (>30 mg/ml)
form: solid
color: Off-white to pale orange
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 218457-67-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3460
Product name: CB-103
Purity: ≥97% (HPLC)
Packaging: 10MG
Price: $64.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3460
Product name: CB-103
Purity: ≥97% (HPLC)
Packaging: 50MG
Price: $261
Updated: 2024/03/01

TRC

Product number: A594853
Product name: 5-Amino-2-(4-tert-butylphenoxy)pyridine
Packaging: 500mg
Price: $90
Updated: 2021/12/16

TRC

Product number: A594853
Product name: 5-Amino-2-(4-tert-butylphenoxy)pyridine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR8051
Product name: 6-[4-(tert-Butyl)phenoxy]pyridin-3-amine
Purity: 97%
Packaging: 1g
Price: $105
Updated: 2021/12/16

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5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Chemical Properties,Usage,Production

Description

CB-103 (218457-67-1) is an orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 μM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines.? CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors.

References

Lehal et al. (2020), Pharmacological disruption of the Notch transcription factor complex; Proc. Natl. Acad. Sci. USA, 117 16292

5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Suppliers

China 62 Germany 2 India 1 Ukraine 1 United Kingdom 6 United States 17 Global 89

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218457-67-1, 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINERelated Search:

PF-01367338 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide METHOPRENE ACID Acalabrutinib 1-Bromo-4-tert-butylbenzene 4-t-Butylbenzamide 3-Amino-6-hydroxypyridine 2-methoxy-5-aminopyridine 6-PHENOXY-3-PYRIDINAMINE 2-PHENOXYPYRIDINE 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE

6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97%

6-[4-(tert-Butyl)phenoxy]pyridin-3-amine97%

5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE

6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE

BUTTPARK 96\12-100

6-(4-tert-butylphenoxy)-3-pyridinamine

3-Pyridinamine, 6-[4-(1,1-dimethylethyl)phenoxy]-

pathway,CB103,inhibit,Inhibitor,Notch,CB-103,signaling,leukemia,CB 103

6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine

Limantrafin

218457-67-1

C15H18N2O

ARYL AMINE