1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

Product Name: 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
CAS No.: 28289-54-5
Chemical Name: 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
Synonyms: MPTP;NSC 139654;Naphthoic Acid Impurity 111;1-METHYL-4-PHENYL-PIPERIDINE-3-EN;1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin;1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine;1,2,3,6-tetrahydro-1-methyl-4-phenyl-pyridin;1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE;1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE;N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE
CBNumber: CB8254906
Molecular Formula: C12H15N
Formula Weight: 173.25
MOL File: 28289-54-5.mol

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1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Property

Melting point:: aprox. 36°C
Boiling point:: 128-132 °C12 mm Hg(lit.)
Density: 1.001±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)
pka: 8.66±0.40(Predicted)
form: Solid
color: Pale Yellow to Light Yellow
Merck: 13,6319
Stability:: Stable. Incompatible with strong oxidizing agents.

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Safety

Hazard Codes: T
Risk Statements: 25-39/23/24/25
Safety Statements: 45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: UT8358900
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 28289-54-5(Hazardous Substances Data)
Toxicity: Human toxicity originally discovered when it was an unexpected by-product from the illicit synthesis of a heroin substitute (i.e., meperidine analog). Currently used experimentally as the primary animal model for the study of Parkinson’s disease. MPTP is a neurotoxicant that is activated to 1-methyl-4-phenylpyridinium ion (MPP1) by the actions of monoamine oxidase B located in the mitochondria of brain astrocytes. The MPP1 is then transported into dopamine, and to a lesser extent, other monoaminergic neurons. Once inside these dopamine neurons in the substantia nigra, it destroys these neurons by mechanisms that may involve an oxidative cascade and/or inhibition of electron transport. Intoxication causes a parkinsonism syndrome almost identical in signs and symptoms to Parkinson’s disease, including rigidity, bradykinesia, tremor, and postural instability. In the event of known ingestion, immediate (but not delayed) administration of a monoamine oxidase inhibitor (especially one selective for MAO-B like deprenyl) and dopamine uptake inhibitor can be therapeutic.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H370Causes damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological

Product number: M3529-60
Product name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Packaging: 25mg
Price: $496
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-1-GU
Product name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydroxpyridine
Purity: 95%
Packaging: 250mg
Price: $368
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 12172
Product name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Packaging: 25mg
Price: $860
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-1-GU
Product name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydroxpyridine
Purity: 95%
Packaging: 1g
Price: $912
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0018205
Product name: 1-METHYL-4-PHENYL-PIPERIDINE-3-EN
Purity: 95.00%
Packaging: 25MG
Price: $721.88
Updated: 2021/12/16

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1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Solid

Uses

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

Definition

ChEBI: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.

Metabolic pathway

N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in a rat pheochromocytoma cell line is oxidized to give the N-methyl-4-phenylpyridinium ion.

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Suppliers

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View Lastest Price from 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE manufacturers

Career Henan Chemical Co

Product: 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE 28289-54-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-30

28289-54-5, 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINERelated Search:

3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE phenindamine Setiptiline 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Xaliproden hydrochloride 3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOLE-5-CARBOXYLIC ACID HYDROCHLORIDE 1-METHYL-4-(2-METHYLPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE Flupranone 2,3-dihydro-2-methyl-9-phenyl-1H-indeno[2,1-c]pyridine hydrobromide 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE phenindamine tartrate ROXINDOLE MESYLATE METHYL-4-PHENYL 1,2,3,6-TETRAHYDROPYRIDINE, 1-, [METHYL-3H] 2-METHYL-9-PHENYL-2,3,4,9-TETRAHYDRO-1-PYRIDINENE TARTRATE METHYL-4-PHENYL 1,2,3,6-TETRAHYDROPYRIDINE, 1-, [METHYL-14C] 1-phenyl-4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)butan-1-one Fenpipalone

MPTP

1,2,3,6-tetrahydro-1-methyl-4-phenyl-pyridin

1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)ochloride

NSC 139654

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, free base

Pyridine,1,2,3,6-tetrahydro-1-methyl-4-phenyl-

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin

1-METHYL-4-PHENYL-PIPERIDINE-3-EN

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE

1-METHYL-4-PHENYL-1,2,3,6-TETRA-*HYDROPY RIDINE FREE

N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE

MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine)

C12H15N 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE 28289-54-5

Naphthoic Acid Impurity 111

28289-54-5

8289-54-5

Building Blocks

C9 to C46

Heterocyclic Building Blocks

Pyridines

Neurochemicals

Heterocyclic Compounds