1H-Imidazole, 2-(trifluoromethyl)-

Product Name: 1H-Imidazole, 2-(trifluoromethyl)-
CAS No.: 66675-22-7
Chemical Name: 1H-Imidazole, 2-(trifluoromethyl)-
Synonyms: SW-1;SWF-1;1H-IMidazole, 2-(trifluor...;2-(trifluoroMethyl)iMidazole;1H-IMidazole, 2-(trifluoroMethyl)-
CBNumber: CB82552792
Molecular Formula: C4H3F3N2
Formula Weight: 136.08
MOL File: 66675-22-7.mol

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1H-Imidazole, 2-(trifluoromethyl)- Property

Melting point:: 145-147 °C(Solv: chloroform (67-66-3))
Boiling point:: 186.1±40.0 °C(Predicted)
Density: 1.440±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: solid
pka: 10.65±0.10(Predicted)
color: white to off-white
InChI: InChI=1S/C4H3F3N2/c5-4(6,7)3-8-1-2-9-3/h1-2H,(H,8,9)
InChIKey: KJMXVHBTWJSSBL-UHFFFAOYSA-N
SMILES: C1(C(F)(F)F)NC=CN=1

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Safety

HS Code: 2933299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T779140
Product name: 2-Trifluoromethylimidazole
Packaging: 50mg
Price: $120
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-3-3Z
Product name: 2-(Trifluoromethyl)-1H-imidazole
Packaging: 250mg
Price: $125
Updated: 2021/12/16

ChemSupplyAustralia

Product number: 400002
Product name: 2-(Trifluoromethyl)-1H-imidazole
Packaging: 1g
Price: $255
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-3-3Z
Product name: 2-(Trifluoromethyl)-1H-imidazole
Packaging: 1g
Price: $375
Updated: 2021/12/16

Matrix Scientific

Product number: 112701
Product name: 2-(Trifluoromethyl)-1H-imidazole
Packaging: 1g
Price: $473
Updated: 2021/12/16

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1H-Imidazole, 2-(trifluoromethyl)- Chemical Properties,Usage,Production

Uses

2-Trifluoromethylimidazole is an intermediate used to prepare sulfonamide derivatives as amyloid β prodn. inhibitors useful in treating or preventing diseases related to Aβ.

Synthesis

131543-46-9

421-53-4

66675-22-7

General procedure for the synthesis of 2-(trifluoromethyl)-1H-imidazole from the compound (CAS:131543-46-9) and 2,2,2-trifluoroethane-1,1-diol: 20 mL of ammonia aqueous solution was added to a three-necked flask at room temperature and stirred. Subsequently, 5 mL of trifluoroacetaldehyde hydrate was mixed with 5 mL of glyoxal and slowly added dropwise to the aqueous ammonia solution, and the reaction was carried out for 2 hours at room temperature. After the reaction was completed, 20 mL of ethyl acetate was added for extraction for 30 minutes. The ethyl acetate layer was separated and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give a final 4.2 g of brown oily product, 2-(trifluoromethyl)-1H-imidazole.

References

[1] Patent: CN107365272, 2017, A. Location in patent: Paragraph 0018; 0019

1H-Imidazole, 2-(trifluoromethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Imidazole, 2-(trifluoromethyl)- Suppliers

China 69 India 2 United States 8 Global 79

Nanjing dekerui pharmaceutical chemical co., LTD

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SPIRO PHARMA

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View Lastest Price from 1H-Imidazole, 2-(trifluoromethyl)- manufacturers

Hangzhou Milon Pharmatech Co.,Ltd.

Product: 2-(trifluoroMethyl)imidazole 66675-22-7
Price: US $0.00-0.00/G
Min. Order: 100G
Purity: 97.0%min；99.0%min
Supply Ability: MAKE TO ORDER
Release date: 2025-12-01

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 1H-Imidazole, 2-(trifluoromethyl)- 66675-22-7
Price: US $500.00-2200.00/g
Min. Order: 5g
Purity: 99%
Supply Ability: 50
Release date: 2024-07-12

66675-22-7, 1H-Imidazole, 2-(trifluoromethyl)-Related Search:

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1H-IMidazole, 2-(trifluoroMethyl)-

2-(trifluoroMethyl)iMidazole

SWF-1

SW-1

1H-IMidazole, 2-(trifluor...

66675-22-7