ChemicalBook > CAS DataBase List > SGI-1776

SGI-1776

Product Name
SGI-1776
CAS No.
1025065-69-3
Chemical Name
SGI-1776
Synonyms
CS-504;I-1776;SGI-1776;S I-1776;SGI-1776, >=98%;SGI-1776;SGI1776;I-1776 free base;SGI-1776 free base;SGI-1776 USP/EP/BP;Pim-Kinase Inhibitor IX
CBNumber
CB82561495
Molecular Formula
C20H22F3N5O
Formula Weight
405.42
MOL File
1025065-69-3.mol
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SGI-1776 Property

Density 
1.37
storage temp. 
Store at -20°C
solubility 
≥40.5 mg/mL in DMSO; insoluble in H2O; ≥101 mg/mL in EtOH
pka
9.22±0.10(Predicted)
form 
Solid
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16423
Product name
SGI-1776
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16423
Product name
SGI-1776
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
16423
Product name
SGI-1776
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
16423
Product name
SGI-1776
Purity
≥98%
Packaging
50mg
Price
$759
Updated
2024/03/01
Usbiological
Product number
474186
Product name
SGI-1776
Packaging
100mg
Price
$1677
Updated
2021/12/16
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SGI-1776 Chemical Properties,Usage,Production

Uses

A novel, ATP competitive inhibitor of Pim1, Pim2 and Pim3 with IC50s of 7 nM, 363 nM and 69 nM, respectively.

Uses

SGI-1776 is a Pim-1 kinase inhibitor. Potent PIM inhibitor.

Definition

ChEBI: N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-6-imidazo[1,2-b]pyridazinamine is a member of imidazoles.

Biological Activity

sgi-1776 free base, n-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent atp-competitive inhibitor of the serine/threonine family of pim kinase, an enzyme regulating cell survival. through extensive biomedical characterization, sgi-1776 exhibits specificity to the three isoforms of the pim family, including pim-1, pim-2, and pim-3. according to preliminary results from studies treating prostate cancer cells, sgi-1776 dose-dependently reduces phosphorylation of known pim kinase substrates involved in cell cycle progression and apotosis (p21cip1/waf1 and bad), compromises overall cell viability by inducing g1 cell cycle arrest and triggering apoptosis, and reduces cell viability in a multidrug resistance 1 (mdr1) protein based taxane-refractory prostate cancer cell line.shannon m. mumenthaler, patricia y.b. ng, amanda hodge, davide bearss, gregory berk, sarath kanekal, sanjeev redkar, pietro taverna, davide b. agus, and anjali jain. pharmacological inhibition of pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes. mol cancer ther. 2009; 8(10): 2882-2893lisa s. chen, s anjeev redkar, david bearss, william g. wierda and varsha gandhi. pim kinase inhibitor, sgi-1776, induces apoptosis in cll lymphocytes. blood. 2009; 114(19): 4150-4157

target

Pim1

SGI-1776 Preparation Products And Raw materials

Raw materials

Preparation Products

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SGI-1776 Suppliers

J & K SCIENTIFIC LTD.
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View Lastest Price from SGI-1776 manufacturers

Career Henan Chemical Co
Product
SGI-1776 1025065-69-3
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-10
Career Henan Chemical Co
Product
SGI-1776 1025065-69-3
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-01-10

1025065-69-3, SGI-1776Related Search:


  • N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine
  • N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine SGI-1776
  • SGI-1776
  • SGI-1776 free base
  • N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine
  • SGI-1776, >=98%
  • SGI-1776 free base N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine
  • SGI-1776 FREE BASE;SGI1776
  • N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-am
  • SGI-1776 free base1025065-69-3
  • SGI-1776;SGI1776
  • CS-504
  • Pim-Kinase Inhibitor IX
  • I-1776
  • I-1776 free base
  • Imidazo[1,2-b]pyridazin-6-amine, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-
  • SGI-1776 USP/EP/BP
  • S I-1776
  • SGI-1776, 10 mM in DMSO
  • 1025065-69-3
  • C20H22F3N5O
  • Inhibitors
  • JAK
  • STAT
  • Inhibitor
  • JAK/STAT