ChemicalBook > CAS DataBase List > 4-broMo-7-fluoro-2,3-dihydroinden-1-one

4-broMo-7-fluoro-2,3-dihydroinden-1-one

Product Name
4-broMo-7-fluoro-2,3-dihydroinden-1-one
CAS No.
1003048-72-3
Chemical Name
4-broMo-7-fluoro-2,3-dihydroinden-1-one
Synonyms
4-BroMo-7-fluoro-2,3-dihydro-1H-inden-1-one;4-Bromo-7-fL;4-broMo-7-fluoro-2;4-Bromo-7-fluoro-1-indanone;4-Bromo-7-fluoroindan-1-one;4-bromo-7-fluoraindane-1-one;uoro-2,3-dihydro-1H-inden-1-one;4-broMo-7-fluoro-2,3-dihydroinden-1-one;4-Bromo-7-fluoro-2,3-dihydro-1-indanone;Bromo-7-fluoro-2,3-dihydro-1H-inden-1-one
CBNumber
CB82603344
Molecular Formula
C9H6BrFO
Formula Weight
229.05
MOL File
1003048-72-3.mol
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4-broMo-7-fluoro-2,3-dihydroinden-1-one Property

Boiling point:
310.7±42.0 °C(Predicted)
Density 
1.691±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
color 
White to yellow
InChI
InChI=1S/C9H6BrFO/c10-6-2-3-7(11)9-5(6)1-4-8(9)12/h2-3H,1,4H2
InChIKey
HNXHWYGTXAJDEC-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C(Br)=CC=C2F)CC1
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Safety

HS Code 
2914390090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
B688865
Product name
4-​Bromo-​7-​fluoro-​2,​3-​dihydroinden-​1-​one
Packaging
1g
Price
$495
Updated
2021/12/16
TRC
Product number
B688865
Product name
4-​Bromo-​7-​fluoro-​2,​3-​dihydroinden-​1-​one
Packaging
2.5g
Price
$875
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0365783
Product name
4-BROMO-7-FLUORO-2,3-DIHYDRO-1H-INDEN-1-ONE
Purity
95.00%
Packaging
5MG
Price
$500.38
Updated
2021/12/16
Apolloscientific
Product number
PC49069
Product name
4-Bromo-7-fluoroindan-1-one
Packaging
1g
Price
$187
Updated
2021/12/16
SynQuest Laboratories
Product number
2717-B-02
Product name
4-Bromo-7-fluoroindan-1-one
Packaging
1g
Price
$221
Updated
2021/12/16
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4-broMo-7-fluoro-2,3-dihydroinden-1-one Chemical Properties,Usage,Production

Uses

4-?Bromo-?7-?fluoro-?2,?3-?dihydroinden-?1-?one is a reactant or reagent used in the preparation of indanyloxydihydrobenzofuranylacetic acids which are suitable for treatment of metabolic diseases.

Synthesis

651735-59-0

1003048-72-3

General procedure for the synthesis of 4-bromo-7-fluoroindanone using 7-fluoro-2,3-dihydro-1H-inden-1-one as starting material: 7-fluoro-2,3-dihydro-1H-inden-1-one (5.3 g, 35.3 mmol) was added to a solution of aluminum chloride (11.77 g, 88 mmol) in dichloroethane (100 mL) at room temperature, followed by a slow, dropwise addition of bromine ( 1.91 mL, 37.1 mmol). The reaction mixture was heated at 65 °C with stirring for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and carefully poured into a mixture of ice and 1N aqueous hydrochloric acid solution. The mixture was extracted with ether (200 mL x 2) and the organic phases were combined. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with an eluent gradient of 0-10% ethyl acetate/hexane to give 4-bromo-7-fluoroindanone (5.2 g, 64% yield). The mass spectrum (DC1/NH3) showed m/z 246 (M + NH4)+.

References

[1] Patent: US2013/158067, 2013, A1. Location in patent: Paragraph 0540
[2] Patent: WO2018/172852, 2018, A1. Location in patent: Page/Page column 102; 103

4-broMo-7-fluoro-2,3-dihydroinden-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-broMo-7-fluoro-2,3-dihydroinden-1-one manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-broMo-7-fluoro-2,3-dihydroinden-1-one 1003048-72-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-16
Career Henan Chemical Co
Product
4-broMo-7-fluoro-2,3-dihydroinden-1-one 1003048-72-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

1003048-72-3, 4-broMo-7-fluoro-2,3-dihydroinden-1-oneRelated Search:

Bromisoval 1-BroMoheptadecafluorooctane 4-BROMO-7-CHLORO-1-INDANONE 4-Bromo-7-methoxy-indan-1-one 4-Bromo-1-indanone 4-Bromo-5-chloro-2,3-dihydro-1H-inden-1-one 4-BROMO-6-FLUOROINDAN-1-ONE 4-Isopropylphenol

  • 4-broMo-7-fluoro-2,3-dihydroinden-1-one
  • 4-BroMo-7-fluoro-2,3-dihydro-1H-inden-1-one
  • 4-Bromo-2,3-dihydro-7-fluoro-1H-inden-1-one, 4-Bromo-2,3-dihydro-7-fluoro-1-oxo-1H-indene
  • 4-Bromo-7-fluoroindan-1-one
  • 4-Bromo-7-fluoro-1-indanone
  • 4-Bromo-7-fluoro-2,3-dihydro-1-indanone
  • 4-Bromo-7-fL
  • uoro-2,3-dihydro-1H-inden-1-one
  • 1H-Inden-1-one, 4-bromo-7-fluoro-2,3-dihydro-
  • 4-broMo-7-fluoro-2
  • 4-bromo-7-fluoraindane-1-one
  • Bromo-7-fluoro-2,3-dihydro-1H-inden-1-one
  • 4-Bromo-7-fluoro-2,3-dihydro-1H-inden-1-one, 97%min
  • 1003048-72-3