4,6-diMethoxypyriMidine-5-carbaldehyde
- Product Name
- 4,6-diMethoxypyriMidine-5-carbaldehyde
- CAS No.
- 4558-59-2
- Chemical Name
- 4,6-diMethoxypyriMidine-5-carbaldehyde
- Synonyms
- 4,6-diMethoxypyriMidine-5-carbaldehyde;4,6-Dimethoxy-5-pyrimidinecarboxaldehyde;5-Pyrimidinecarboxaldehyde, 4,6-dimethoxy-
- CBNumber
- CB82606097
- Molecular Formula
- C7H8N2O3
- Formula Weight
- 168.15
- MOL File
- 4558-59-2.mol
4,6-diMethoxypyriMidine-5-carbaldehyde Property
- Melting point:
- 142-143℃ (water ethanol )
- Boiling point:
- 335.9±37.0 °C(Predicted)
- Density
- 1.240±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.22±0.26(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 6282AB
- Product name
- 4,6-Dimethoxypyrimidine-5-carbaldehyde
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- NUC0001842
- Product name
- 4,6-DIMETHOXYPYRIMIDINE-5-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $983.52
- Updated
- 2021/12/16
- Product number
- NUC0001842
- Product name
- 4,6-DIMETHOXYPYRIMIDINE-5-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1473.14
- Updated
- 2021/12/16
- Product number
- NUC0001842
- Product name
- 4,6-DIMETHOXYPYRIMIDINE-5-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1928.08
- Updated
- 2021/12/16
- Product number
- CM131941
- Product name
- 4,6-dimethoxypyrimidine-5-carbaldehyde
- Purity
- 96%
- Packaging
- 10g
- Price
- $1169
- Updated
- 2021/12/16
4,6-diMethoxypyriMidine-5-carbaldehyde Chemical Properties,Usage,Production
Synthesis
67-56-1
5305-40-8
4558-59-2
4,6-Dichloropyrimidine-5-carbaldehyde (5 g, 28.25 mmol) was suspended in anhydrous methanol (100 mL). Potassium carbonate (7.8 g, 56.5 mmol) was added to the suspension and the reaction mixture was subsequently stirred at 90 °C for 1 hour. After completion of the reaction, the solvent was removed by concentration under reduced pressure to give a residue. The residue was dissolved in a solvent mixture of water (100 mL) and dichloromethane (100 mL) for liquid-liquid separation. The aqueous phase was further extracted with dichloromethane (50 mL x 3). All organic phases were combined and concentrated under reduced pressure to obtain the residue. The residue was diluted in dichloromethane/petroleum ether (1 mL/20 mL) and stirred at room temperature for 3 hours. Subsequently, the yellow solid product was collected by diafiltration. Finally, the product was purified using silica gel column chromatography (petroleum ether/ethyl acetate, 5:1, v/v) to afford 4,6-dimethoxy-5-pyrimidinecarboxaldehyde as a white solid (2.2 g, 46.3% yield).
References
[1] Patent: CN104513235, 2017, B. Location in patent: Paragraph 1355; 1356; 1357; 1384; 1385; 1386
4,6-diMethoxypyriMidine-5-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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