ChemicalBook > CAS DataBase List > ACY-1215

ACY-1215

Product Name
ACY-1215
CAS No.
1316214-52-4
Chemical Name
ACY-1215
Synonyms
ACY 63;CS-583;ACY-1215;Propane-1;Ricolinostat;Rocilinostat;ACY-1215/ACY1215;Rocilinostat, >=99%;3-tricarboxylic acid;β-Carboxyglutaric acid
CBNumber
CB82627292
Molecular Formula
C24H27N5O3
Formula Weight
433.5
MOL File
1316214-52-4.mol
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ACY-1215 Property

Melting point:
189 - 191°C
Density 
1.239±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
9.47±0.20(Predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21531
Product name
ACY-1215
Purity
≥98%
Packaging
25mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
21531
Product name
ACY-1215
Purity
≥98%
Packaging
50mg
Price
$129
Updated
2024/03/01
Cayman Chemical
Product number
21531
Product name
ACY-1215
Purity
≥98%
Packaging
100mg
Price
$228
Updated
2024/03/01
Cayman Chemical
Product number
21531
Product name
ACY-1215
Purity
≥98%
Packaging
250mg
Price
$494
Updated
2024/03/01
TRC
Product number
D486990
Product name
2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide
Packaging
250mg
Price
$275
Updated
2021/12/16
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ACY-1215 Chemical Properties,Usage,Production

Description

ACY-1215 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 5 nM). It is at least 10-fold less active against other HDACs in enzymatic assays. ACY-1215 shows synergistic activity with the proteasome inhibitor bortezomib against multiple myeloma (MM) cells, inducing protracted endoplasmic reticulum stress and apoptosis. ACY-1215 combined with proteasome inhibitors suppresses tumor growth and increases survival in mice with MM and mantle cell lymphoma xenografts. A multicenter phase I trial examining ACY-1215 combined with the E3 ligase inhibitor lenalidomide and dexamethasone in multiple myeloma found inhibition of HDAC6 in vivo. ACY-1215 also diminishes liver cyst development and fibrosis in a rat model of polycystic liver disease.

Uses

This compound acts as a selective HDAC-6 (histone deacetylase) inihibitor. HDAC is linked to the transcription of DNA in cancers, including multiple myeloma (MM).

Definition

ChEBI: N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)-5-pyrimidinecarboxamide is a pyrimidinecarboxylic acid.

target

HDAC6

ACY-1215 Preparation Products And Raw materials

Raw materials

Preparation Products

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ACY-1215 Suppliers

Canada 1 China 143 India 1 United Kingdom 1 United States 18 Global 164
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
ApexBio Technology LLC
Tel
+1-832-696-8203
Fax
+1-832-641-3177
Email
info@apexbt.com
Country
United States
ProdList
477
Advantage
60
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
ChemShuttle. Inc.
Tel
--
Fax
--
Email
Sales@ChemShuttle.com
Country
United States
ProdList
6695
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Selleck Chemicals LLC
Tel
--
Fax
--
Email
info@selleckchem.com
Country
United States
ProdList
824
Advantage
60
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View Lastest Price from ACY-1215 manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
ACY-1215 1316214-52-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-29
Henan Aochuang Chemical Co.,Ltd.
Product
ACY-1215 1316214-52-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13

1316214-52-4, ACY-1215Related Search:

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  • Rocilinostat (ACY-1215)
  • 2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide
  • ACY 63
  • 2-(DiphenylaMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide
  • RICOLINOSTAT;ACY1215;ACY 1215
  • Rocilinostat, >=99%
  • 5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-
  • 2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide ACY 1215
  • Ricolinostat
  • N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide
  • Parathyroid hormone - Shire
  • ACY-1215
  • Rocilinostat
  • ACY-1215 (Rocilinostat)
  • ACY-1215/ACY1215
  • Ricolinostat (ACY-1215)
  • CS-583
  • ROCILINOSTAT; ACY1215; ACY 1215;RICOLINOSTAT
  • 1316214-52-4 ACY1215,ROCILINOSTAT
  • 7-{[2-(Diphenylamino)pyrimidin-5-yl]formamido}-N-hydroxyheptanamide
  • 3-tricarboxylic acid
  • Propane-1
  • β-Carboxyglutaric acid
  • ACY-1215 ACY-63 Ricolinostat ACY1215
  • 2- (Diphenylamino) - N - [7- (hydroxyamino) -7-oxoheptyl] -5-pyrimidine carboxylamide
  • 1316214-52-4
  • Inhibitors
  • Inhibitor